GH Receptor Antagonists: Basic Knowledge and Clinical Perspectives

  • A. J. van der Lely
Conference paper


GH is a protein that contains 191 amino acids with two disulfide bonds and four a helices (Abdel-Meguid et al., 1987; de Vos et al., 1992). Its molecular mass is approximately 22 kDa. GH is secreted by the anterior pituitary gland (Theill and Karin, 1993; Ohlsson et al., 1998). GH signal transduction begins with GH binding to a transmembrane GH receptor (Lesniak et al., 1973). GH has two distinct binding domains that bind to two identical GHRs at the cell surface. The initial (high-affinity) binding of the GH binding site I at the GHR is followed by binding at the GH site II, which produces functional receptor dimerization of the two GHRs (de Vos et al., 1992; Carter-Su et al., 2000).


Growth Hormone Growth Hormone Receptor Active Acromegaly Growth Hormone Binding Growth Hormone Receptor Antagonist 
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