Epidemiology and Natural History

  • Dario Ribero
Part of the Updates in Surgery book series (UPDATESSURG)


Although the vast majority of patients with a large-bowel primary have tumors amenable to curative resection at the time of diagnosis, the disease recurs in more than half of the patients, with the liver involved in up to two-thirds of the cases. Synchronous liver metastases are diagnosed in approximately 15% of the cases. In such patients, liver disease represents the sole site of distant metastases in more than 75%. Metachronous liver metastases develop in 16–20% of patients usually within the first 3 years. Untreated liver metastases have a grim prognosis. Liver resection is the only potentially curative treatment although only 20% of patients can be considered as candidates for surgery.


Colorectal Cancer Rectal Cancer Liver Metastasis Hepatic Resection Hepatic Metastasis 
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Copyright information

© Springer-Verlag Italia 2011

Authors and Affiliations

  • Dario Ribero
    • 1
  1. 1.Division of Hepato-Bilio-Pancreatic and Digestive SurgeryMauriziano “Umberto I” HospitalTurinItaly

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