Skip to main content

Tumori maligni epiteliali dell’orofaringe

  • Chapter
Tumori della testa e del collo
  • 897 Accesses

Riassunto

L’orofaringe si estende da un piano passante per il palato duro fino a un piano passante al limite superiore dell’osso ioide. Si divide in 4 parti che corrispondono a una parete superiore, palato molle e ugula; a una parete laterale destra e una sinistra, tonsilla, loggia tonsillare, pilastri tonsillari, solco amigdaloglosso; a una parte anteriore base lingua e vallecule; a una parte posteriore mucosa e tessuti posti al davanti del piano vertebrale. Ciascuna sede e sottosede ha una storia naturale con caratteristiche peculiari di cui si deve tener conto nelle indicazioni terapeutiche. Il drenaggio linfatico è relativo alle sottosedi interessate e può coinvolgere i retrofaringei (parete posteriore), i livelli II, III, IV in prima istanza (parete laterale, parete anteriore). La tendenza a dare metastasi linfonodali varia a seconda delle sottosedi interessate e dallo stadio di malattia (Tabella 23.1). La possibilità di metastatizzazione è comunque molto elevata, in ragione della presenza di una ricca rete linfatica (anello del Waldeyer). La bilateralità della metastatizzazione dipende dalla centralità o meno della sottosede interessata (palato molle, base lingiale) o dall’omolateralità (tonsilla).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 119.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 139.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Bibliografia

  1. Werner JA, Davis RK (eds) (2004) Metastases in Head and Neck Cancer. Springer, Berlin Heidelberg New York, pp 45–55

    Book  Google Scholar 

  2. Gassner HG, Sabri AN, Olsen KD (2005) Oropharyngeal malignancy. In: Cummings CW (ed) Cummings’ Otorhinolaryngology-Head & Neck Surgery. Mosby, St. Luis

    Google Scholar 

  3. Marur S, Forastiere AA (2008) Head and neck Cancer: changing epidemiology, diagnosis and treatment. Mayo Clin Pro 83:489–501

    Article  Google Scholar 

  4. Licitra L, Zigon G, Gatta G (2008) Human papillomavirus in HNSCC: a European epidemiologic perspective EU-ROCARE Working Group. Hematol Oncol Clin North Am 22:1143–1153

    Article  PubMed  Google Scholar 

  5. Fakhry C, Gillison ML (2006) Clinical implication of human papillomavirus in head and neck cancer. J Clin Oncol 24:2606–2611

    Article  PubMed  Google Scholar 

  6. Gillison ML, Koch WM, Capone RB et al (2000) Evidence for a causal association between human papillomavirus in a subset of head and neck cancers. J Natl Cancer Inst 92:709–720

    Article  PubMed  CAS  Google Scholar 

  7. Licitra L, Perrone F, Bossi P et al (2006) High-risk human papillomavirus affects prognosis in patients with surgically treated oropharyngeal squamous cell carcinoma. J Clin Oncol 24:5630–5636

    Article  PubMed  CAS  Google Scholar 

  8. Ragin CC, Taioli E (2007) Survival of squamous cell carcinoma of the head and neck in relation to human papillomavirus infection: review and meta-analysis. Int J Cancer 121:1813–1820

    Article  PubMed  CAS  Google Scholar 

  9. Duvvun U, Umamaheswar GS, Myers JN, Jeffrey N (2009) Contemporary Management of Oropharyngeal Cancer. Cunent problems in Surgery 46:119–184

    Article  Google Scholar 

  10. Sedaghat AR, Zhang Z, Begum S et al (2009) Prognostic Significance of Human Papillomavirus in Oropharyngeal Squamous Cell Carcinoma. Laryngoscope 119:1542–1549

    Article  PubMed  Google Scholar 

  11. Fallai C, Perrone F, Licitra L et al (2009) Oropharyngeal squamous cell carcinoma treated with radiotherapy or radiochemotherapy: prognostic role of 53 and HPV status. Int J Radiat Oncol Biol Phys 75:1053–1059

    Article  PubMed  Google Scholar 

  12. Nichols AC, Faquin WC, Westra WH et al (2009) HPV-16 infection predicts treatment outcome in oropharygeal squamous cell caricinoma. Otolaryngology-Head and Neck Surgery 140:228–234

    Article  PubMed  Google Scholar 

  13. Lindel K, Beer KT, Laissue J et al (2001) Human Papillomavirus Positive Squamous Cell Carcinoma of the Oropharynx. Cancer 92:805–813

    Article  PubMed  CAS  Google Scholar 

  14. Ragin CC, Taioli E (2007) Survival of squamous cell carcinoma of the head and neck in relation to human papillomavirus infectiomreview and meta-analysis. Int J Cancer 121:1813–1820

    Article  PubMed  CAS  Google Scholar 

  15. Shuman AG, Wolf GT (2010) Human papillomavirus status in head and neck cancer: the ethics of disclosure. Cancer 116:4221–6

    Article  PubMed  Google Scholar 

  16. Strobel K, Haerle Sk, Stoeckli SJ et al (2009) Head and neck asquamous cell carcinoma (HNSCC)-detection of synchronous primaries with (189) F-FDG-PET/CT. Eur J Nucl Med Mol Imaging 36:919–927

    Article  PubMed  Google Scholar 

  17. Ng SH, Liao CT, Chang JT et al (2008) Distant metastases and synchronous second primary tumors in patients with newly diagnosed oropharyngeal and hypopharyngeal carcinomas: evaluation of (18)F-FDG PET and extended-field mulyidetector row CT Neuroradiology 50:969–979

    Article  PubMed  Google Scholar 

  18. Bernier J, Cooper JS, Pajack TFet al (2005) Defining Risk levels in locally advanced head and neck cancers: a comparative analysis of concurrent postoperative radiation plus chemotherapy trials of the EORTC (# 22931) and RTOG (#9501). Head and Neck 27:843–850

    Article  PubMed  Google Scholar 

  19. Cosmidis A, Rame JP, Dassonville O et al (2004) Groupement d’Etudes des Tumeurs de la Téte et du Cou (GET-TEQ.T1-T2 NO oropharyngeal iancers treated with surgery alone. A GETTEC study. Eur Arch Otorhinolaryngol 261:276–281

    Article  Google Scholar 

  20. Mendenhall WM, Morris CG, Amdur RJ et al (2006) Definite radiotherapy for tonsillar squamous cell carcinoma. Am J Clin Oncol 29:290–297

    Article  PubMed  Google Scholar 

  21. Mendenhall WM, Stringer SP, Amdur RJ et al (2000b) Is radiation therapy a preferred alternative to surgery for squamous cell carcinoma of the base of tongue? J Clin Oncol 18:35–42

    PubMed  CAS  Google Scholar 

  22. Mendenhall WM, Amdur RJ, Stringer SP et al (2000a) Radiation therapy for squamous cell carcinoma of the tonsillar region: a preferred alternative to surgery? J Clin Oncol 18:2219–2225

    PubMed  CAS  Google Scholar 

  23. O’Sullivan B,Warde P, Grice B et al (2001) The benefits and pitfalls of ipsilateral radiotherapy in carcinoma of the tonsillar region. Int J Radiot Oncol Biol Phys 51:332–343

    Article  Google Scholar 

  24. Huang K, Xia P, Chuang C et al (2008) Intensity-modulated Chemo radiation for treatment of Stage III and IV Oropharyngeal Carcinoma. Cancer 113:497–507

    Article  PubMed  Google Scholar 

  25. Pignon JP, Le Maître A, Maillard E et al (2009) MACH-NC Collaborative Group. Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): an update on 93 randomised trials and 17,346 patients. Radiother Oncol 92:4–14

    Google Scholar 

  26. Corry J, Peters LJ, Rischin D (2010) Optimising the therapeutic ratio in head and neck cancer. Lancet Oncol 11:287–291

    Article  PubMed  Google Scholar 

  27. Rusthoven KE, Raben D, Ballonoff A et al (2008) Effect of radiation techniques in treatment of oropharynx cancer. Laryngoscope 118:635–9

    Article  PubMed  Google Scholar 

  28. Peponi E, Glanzmann C, Willi B et al (2011) Dysphagia in head and neck cancer patients following intensity modulated radiotherapy (IMRT). Radiat Oncol 6:1

    Article  PubMed  Google Scholar 

  29. Marks LB, Ten Haken RK, Martel MK et al (2010) Quantitaive Analysis of Normal Tissue Effects in the Clinic. Int J Radiat Oncol Biol Phys 76:Supp S1–S160

    Article  PubMed  Google Scholar 

  30. Azria D, Bourhis J, de Crevoisier R et al (2010) Dose de Tolerance a irradiation des tissus sains. Cancer/radiotherapie 14:227–410

    Article  Google Scholar 

  31. Orlandi E, Palazzi M, Pignoli E et al (2010) Radiobiological basis and clinical results of the simoultaneus integrated boost (SIB) in intensità modulated Radiotherapy (IM-RT) for head and neck cancer: a review. Crit Rev Oncol/Hematol 73:111–125

    Article  Google Scholar 

  32. Johnston M, Clifford S, Bromley R et al (2011) Volumetric-modulated Arc Therapy in Head and Neck Radiotherapy: A Planning Comparison using Simultaneous Integrated Boost for Nasopharynx and Oropharynx Carcinoma Clin Oncol (R Coll Radiol) [Epub ahead of print]

    Google Scholar 

  33. Chao KS, Ozyigit G, Tran BN et al (2003) Patterns of failure in patients receiving definite and postoperative IMRT for head-and-neck cancer. Int J Radiat Oncol Biol Phys 53:312–321

    Google Scholar 

  34. Eisbruch A, Marsh LH, Dawson LA et al (2004) Recurrences near base of the skull after IMRT for head-andneck cancer: implications for target delineation in high neck for parotid gland sparing. Int J Radiat Oncol Biol Phys 59:28–42

    Article  PubMed  Google Scholar 

  35. de Arruda FF, Puri DR, Zhung J et al (2006). Intensity-modulated radiation therapy for the treatment of oropharyngeal carcinoma: the Memorial Sloan-Kettering cancer Center experience. Int J Radiat Onocl Biol Phys 64:363–373

    Article  Google Scholar 

  36. Eisbruch A, Chao KSC, Garden A, for the Radiation Therapy Oncology Group. RTOG 0022: Phase I /II Study of Conformai and Intensity Modulated Irradiation for Oropharyngeal Cancer www.rtog.org/members/protocols/h0022/ <http://www.rtog.org/members/protocols/h0022/>h0022.pdf; cited March 3, 2006

    Google Scholar 

  37. Hodge CW, Bentzen SM, Wong G et al (2007) Are we influencing outcome in oropharynx cancer within tensitymodulated radiotherapy? An inter-era comparison. Int J Radiat Oncol Biol Phys 69:1032–1041

    Article  PubMed  Google Scholar 

  38. Garden AS, Morrison WH, Wong PF et al (2007) Disiasecontrol rates following intensity-modulated radiation therapy for small primary oropharyngeal carcinoma. Int J Radiat Oncol Biol Phys 67:438–444

    Article  PubMed  Google Scholar 

  39. Huang K, Xia P, Chuang C et al (2008) Intensity-modulated chemoradiation for treatment of stage III and IV of oropharyngeal carcinoma Cancer 113:497–507

    Article  PubMed  Google Scholar 

  40. Daly ME, Le QT, Maxim PG et al (2010) Intensity-modulated radiotherapy in the treatment of oropharyngeal cancer: clinical outcomes and patterns of failure. Int J Radiat Oncol Biol Phys 76:1339–1346

    Article  PubMed  Google Scholar 

  41. Mendenhall WM, Amdur RJ, Morris CG et al (2010) Intensity-modulated radiotherapy for oropharyngeal squamous cell carcinoma. Laryngoscope 119:2218–2222

    Article  Google Scholar 

  42. Horiot JC, leFur R, N’Guyen T et al (1992) Hyperefractionation versus conventional fractionation in oropharyngeal carcinoma:final analysis of a randomized trial of the EORTC cooperative group of radiotherapy. Radiot Oncol 25:231–241

    Article  CAS  Google Scholar 

  43. Bourhis J, Overgaard J, Audry H et al (2006) Hyperfractionated radiotherapy in Head and Neck cancer: a meta-analysis. Lancet 368:843–854

    Article  PubMed  Google Scholar 

  44. Pignon JP, Bourhis J, Domenge C et al (2000) Chemotherapy added to locoregional treatment for head and neck squamous-cell carcinoma: three meta-analyses of updated individual data. MACH-NC Collaborative Group. Meta-Analysis of Chemotherapy on Head and Neck Cancer. Lancet 355:949–955

    CAS  Google Scholar 

  45. Feng FY, Kim HM, Lyden TH et al (2010) Intensity-modulated chemoradiotherapy aiming to reduce dysphagia in patients with oropharyngeal cancer: clinical and functional results. J Clin Oncol 28:2732–2738

    Article  PubMed  Google Scholar 

  46. Bonner JA, Harari PM, Giralt J et al (2010) Radiotherapy plus cetuximab for locoregionally advanced head and neck cancer: 5-year survival data from a phase 3 randomised trial, and relation between cetuximab-induced rash and survival. Lancet Oncol 11:21–28

    Article  PubMed  CAS  Google Scholar 

  47. Ang KK, Harris J, Wheeler R (2010) Human papillomavirus and survival of patients with oropharyngeal cancer. N Engl J Med 363:24–35

    Article  PubMed  CAS  Google Scholar 

  48. Granata R, Perrone F, Miceli R et al (2010) Tumor Stage HPV and smoking status affect the survival of patient with oropharingeal cancer: an Italian studi. Ann Oncol 21:314–328

    Google Scholar 

  49. Posner MR, Lorch JH, Goloubeva O et al (2010) Oropharynx cancer (OPC) in TAX 324: Human papillomavirus (HPV) and survival. J Clin Oncol 28:15s

    Google Scholar 

  50. Common Terminology Criteria for Adverse Events (CT-CAE) Version 4-U.S.DEPARTMENT OF HEALTH AND HUMAN SERVICES, National Institutes of Health, National Cancer Institute

    Google Scholar 

  51. Eisbruch A, Dawson LA, Kim HM et al (1999) Conformai and intensity modulated irradiation of head and neck cancer: the potential for improved target irradiation, salivary gland function, and quality of life. Acta Otorhinolaryngol Belg 53:271–275

    PubMed  CAS  Google Scholar 

  52. Eisbruch A, Ship JA, Dawson LA et al (2003) Salivary gland sparing and improved target irradiation by conformai and intensity modulated irradiation of head and neck cancer. World J Surg 27:832–7

    Article  PubMed  Google Scholar 

  53. Eisbruch A, Schwartz M, Rasch C (2004) Dysphagia and aspiration after chemoradiotherapy for head-and-neck cancer: which anatomic structures are affected and can they be spared by IMRT? Int J Radiat Oncol Biol Phys 5:1425–1439

    Google Scholar 

  54. Feng FY, Kim HM, Lyden TH et al (2007) Intensity-modulated radiotherapy of head and neck cancer aiming to reduce dysphagia: early dose-effect relationships for the swallowing structures. Int J Radiat Oncol Biol Phys 68:1289–1298

    Article  PubMed  Google Scholar 

  55. Sanguined G, Adapala P, Endres EJ et al (2007) Dosimetric predictors of laryngeal edema. Int J Radiat Oncol Biol Phys 68:741–749

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

Copyright information

© 2011 Springer-Verlag Italia

About this chapter

Cite this chapter

Licitra, L., Olmi, P. (2011). Tumori maligni epiteliali dell’orofaringe. In: Tumori della testa e del collo. Springer, Milano. https://doi.org/10.1007/978-88-470-1806-8_23

Download citation

  • DOI: https://doi.org/10.1007/978-88-470-1806-8_23

  • Publisher Name: Springer, Milano

  • Print ISBN: 978-88-470-1805-1

  • Online ISBN: 978-88-470-1806-8

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics