Riassunto
Con il termine di adroterapia si intende l’impiego di adroni, cioè di particelle formate da quark, legate fra loro da forze nucleari che, opportunamente accelerate, vengono impiegate nella cura di patologie neoplastiche. Si tratta dunque di una forma particolare di radioterapia che sfrutta le proprietà fisiche e biologiche di particelle dotate di carica (protoni e ioni) o senza carica (neutroni) per ottenere ionizzazioni delle molecole presenti nelle cellule del tessuto tumorale con l’obiettivo di portare a morte le cellule tumorali stesse e, di conseguenza, ottenere il controllo della malattia tumorale.
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Bibliografia
Suit HD, Chu W. History of charged particle radiotherapy (2008) In: Delaney TF, Kooy HM (eds) Proton and Charged Particle Radiotherapy, 1st edn. Lippincott Williams & Wilkins, Philadelphia
Maor MH, Errington RD, Caplan RJ et al (1995) Fastneutron therapy in advanced head and neck cancer: a collaborative international randomized trial. Int J Radiat Oncol Biol Phys 32:599–604
Laramore GE (1997) The use of neutrons in cancer therapy: a historical perspective through the modern era. Semin Oncol 24:672–685
Kouri M, Kankaanranta L, Seppala T et al (2004) Undifferentiated sinonasal carcinoma may respond to singlefraction boron neutron capture therapy. Radiother Oncol 72:83–85
Suit H, Goldberg S, Niemierko A et al (2003) Proton beams to replace photon beams in radical dose treatments. Acta Oncol 42:800–808
Jereczek-Fossa BA, Krengli M, Orecchia R (2006) Particle beam radiotherapy for head and neck tumors: radiobiological basis and clinical experience. Head Neck 28:750–760
Blakely EA, Ngo FQH, Curtis SB et al (1984) Heavy-ion radiobiology: cellular studies. Adv Radiat Biol 11:295–378
Cozzi L, Fogliata A, Lomax A et al (2001) A treatment planning comparison of 3D conformai therapy, intensità modulated photon therapy and proton therapy for treatment of advanced head and neck tumours. Radiother Oncol 61:287–297
Lomax AJ, Goitein M, Adams J (2003) Intensity modulation in radiotherapy: photons versus protons in the paranasal sinus. Radiother Oncol 66:11–18
Mock U, Georg D, Bogner J et al (2004) Treatment planning comparison of conventional, 3D conformai, and intensity-modulated photon (IMRT) and proton therapy for paranasal sinus carcinoma. Int J Radiat Oncol Biol Phys 58:147–154
Krengli M, Bourhaleb F, Cozzi L et al (2006) Treatment planning comparison of photon IMRT, active and passive proton therapy, and carbon ion therapy for treatment of head and neck tumors. Int J Radiat Oncol Biol Phys 66:S669
Thorwarth D, Soukup M, Alber M (2008) Dose painting with IMPT, helical tomotherapy and IMXT: a dosimetric comparison. Radiother Oncol 86:30–34
Pamir MN et al (2008) Tumor-biology and current treatment of skull-base chordomas. Adv Tech Stand Neurosurg 33:35–129
Grimer RJ, Gosheger G, Taminiau A et al (2007) Dedifferentiated chondrosarcoma: prognostic factors and outcome from a European group. Eur J Cancer 3:2060–2065
Al Mefty K (2007) Chordoma and chondrosarcoma: similar, but quite different, skull base tumors. Cancer 110:2457–2467
Colli BO, Al-Mefty O (2001) Chordomas of the skull base: follow-up review and prognostic factors. Neurosurg Focus 10:E1
Munzenrider JE, Liebsch NJ (1999) Proton therapy of tumors of skull base. Strahlenther Onkol 175:57–63
Hug EB, Loredo LN, Slater JD et al (1999) Proton radiation therapy for chordomas and chondrosarcomas of the skull base. J Neurosurg 91:432–439
Noël G, Feuvret L, Calugaru V et al (2005) Chordomas of the base of the skull and upper cervical spine. One hundred patients irradiated by a 3D conformai technique combining photon and proton beams. Acta Oncol 44:700–708
Ares C, Hug EB, Lomax AJ et al (2009) Effectiveness and safety of spot scanning proton radiation therapy for chordomas and chondrosarcomas of the skull base: first longterm report. Int J Radiat Oncol Biol Phys 75:1111–1118
Castro JR, Linstadt DE, Bahary JP et al (1994) Experience in charged particle irradiation of tumors of the skull base: 1977–1992. Int J Radiat Oncol Biol Phys 29:647–655
Schulz-Ertner D, Nikoghosyan A, Thilmann C et al (2004) Results of carbon ion radiotherapy in 152 patients. Int J Radiat Oncol Biol Phys 58:631–640
Schulz-Ertner D, Karger CP, Feuerhake A et al (2007) Effectiveness of carbon ion radiotherapy in the treatment of skull-base chordomas. Int J Radiat Oncol Biol Phys 68:449–457
Mizoe JE, Hasegawa A, Takagi R et al (2009) Carbon ion radiotherapy for skull base chordoma. Skull Base 19:219–224
Fu KK, Pajak TF, Troth A et al (2000) A radiation therapy oncology group (RTOG) phase III randomized study to compare htperfrachonation and two variants of accelerated fractionation to standard fractionation radiotherapy for head and neck squamous cell carcinomas: first report of RTOG 90-03. Int J Radiat Oncol Biol Phys 48:7–16
Slater JD, Yonemoto LT, Mantik DW et al (2005) Proton radiation for treatment of cancer of the oropharynx: early experience at Loma Linda University Medical Center using a concomitant boost technique. Int J Radiat Oncol Biol Phys 62:494–500
Griffin TW, Davis R, Hendrickson FR et al (1984) Fast neutron radiation therapy for unresectable squamous cell carcinoma of the head and neck: the results of a randomized RTOG study. Int J Radiat Oncol Biol Phys 10:2217–2221
MacDougall RH, Orr JA, Kerr GR et al (1990) Fast neutron treatment for squamous cell carcinoma of the head and neck: final report of Edinburgh randomized trial. BMJ 301:1241–1242
Mizoe JE, Tsujii H, Kamada T et al (2004) Dose escalation study of carbon ion radiotherapy for locally advanced head-and-neck cancer. Organizing Committee for the Working Group for Head-And-Neck Cancer. Int J Radiat Oncol Biol Phys 60:358–364
Lee N, Xia P, Quivey JM et al (2002) Intensity-modulated radiotherapy in the treatment of nasopharyngeal carcinoma: an update of the UCSF experience. Int J Radiat Oncol Biol Phys 53:12–22
Patel S, Adams JA, Busse PM et al (2008) Nasopharynx. In: Delaney TF, Kooy HM (eds) Proton and Charged Particle Radiotherapy, 1st edn. Lippincott Williams & Wilkins, Philadelphia
Trofimov A, Chan AW, Adams JA et al (2005) Potential for improved normal tissue sparing in intensity-modulated proton therapy for nasopharyngeal carcinoma. PTCOG Meeting, Tokyo, Japan
Tiwari R, Hardillo JA, Mehta D et al (2000) Squamous cell carcinoma of maxillary sinus. Head Neck 22:164–169
Rhee CS, Won TB, Lee CH et al (2006) Adenoid cystic carcinoma of the sinonasal tract: treatment results. Laryngoscope 116:982–986
Paulino AC, Marks JE, Bricker P et al (1998) Results of treatment of patients with maxillary sinus carcinoma. Cancer 83:457–465
Dulguerov P, Jacobsen MS, Allai AS et al (2001) Nasal and paranasal sinus carcinoma: are we making progress? A series of 220 patients and a systematic review. Cancer 92:3012–3029
Hoppe BS, Stegman LD, Zelefsky MJ et al (2007) Treatment of nasal cavity and paranasal sinus cancer with modern radiotherapy techniques in the postoperative sethng-the MSKCC experience. Int J Radiat Oncol Biol Phys 67:691–702
Krengli M, Jereczek-Fossa BA, Kaanders JH et al (2008) What is the role of radiotherapy in the treatment of mucosal melanoma of the head and neck? Crit Rev Oncol Hematol 65:121–128
Blanco AI, Chao KS, Ozyigit G et al (2004) Carcinoma of paranasal sinuses: long-term outcomes with radiotherapy. Int J Radiat Oncol Biol Phys 59:51–58
Mendenhall WM, Amdur RJ, Morris CG et al (2009) Carcinoma of the nasal cavity and paranasal sinuses. Laryngoscope 119:899–906
Chan AW, Pommier P, Deschler DG et al (2004) Change in patterns of relapse after combined proton and photon irradiation for locally advanced paranasal sinus cancer. Int J Radiat Oncol Biol Phys 60:S320
Douglas JG, Laramore GE, Austin-Seymour M et al (2000) Treatment of locally advanced adenoid cystic carcinoma of the head and neck with neutron radiotherapy. Int J Radiat Oncol Biol Phys 46:551–557
Schulz-Ertner D, Nikoghosyan A, Didinger B et al (2005) Therapy strategies for locally advanced adenoid cystic carcinomas using modern radiation therapy techniques. Cancer 104:338–344
Blake PR, Catterall M, Errington RD (1985) Treatment of malignant melanoma by fast neutrons. Br J Surg 72:517–519
Yanagi T, Mizoe JE, Hasegawa A et al (2009) Mucosal melanoma of the head and neck treated by carbon ion radiotherapy. Int J Radiat Oncol Biol Phys 74:15–20
Licitra L, Grandi C, Prott FJ et al (2003) Major and minor salivary glands tumours. CritRev Oncol Hematol 45:215–225
Spiro RH, Huvos AG (1992) Stage means more than grade in adenoid cystic carcinoma. Am J Surg 164:623–628
Frankenthaler RA, Luna MA, Lee SS et al (1991) Prognostic variables in parotid gland cancer. Arch Otolaryngol Head Neck Surg 117:1251–1256
Krüll A, Schwarz R, Engenhart R et al (1996) European results in neutron therapy of malignant salivary gland tumors. Bull Cancer Radiother 83:125s–129s
Breteau N, Wachter T, Kerdraon R et al (2000) Use of fast neutrons in the treatment of tumors of the salivary glands: rationale, review of the literature and experience in Orléans. Cancer Radiother 4:181–190
Buchholz TA, Laramore GE, Griffin BR et al (1992) The role of fast neutron radiation therapy in the management of advanced salivary gland malignant neoplasms. Cancer 69:2779–2788
Battermann JJ, Mijnheer BJ (1986) The Amsterdam fast neutron therapy project: a final report Int J Radiat Oncol Biol Phys 12:2093–2099
Catterall M, Errington RD (1987) The implications of improved treatment of malignant salivary gland tumours by fast neutron radiotherapy. Int J Radiat Oncol Biol Phys 13:1313–1318
DuncanW, Orr JA, Arnott SJ et al (1987) Neutron therapy for malignant tumours of the salivary glands. A report of the Edinburgh experience. Radiother Oncol 8:97–104
Eichhorn HJ (1981) Pilot study on neutron therapy. Part 1: The applicability of neutron therapy. Radiobiol Radiother 22:262–292
Griffin BR, Laramore GE, Russell KJ et al (1988) Fast neutron radiotherapy for advanced malignant salivary gland tumours. Radiother Oncol 12:105–111
Griffin TW, Pajak TF, Laramore GE et al (1988) Neutron vs. photon irradiation of inoperable salivary gland tumours: results of an RTOG-MRC Cooperative Randomized Study. Int J Radiat Oncol Biol Phys 15:1085–1090
SarojaKR, Mansell J, Hendrickson FR et al (1987) An update on malignant salivary gland tumours treated with neutrons at Fermilab. Int J Radiat Oncol Biol Phys 13:1319–1325
Skolyszewski J, Byrski E, Chrzanowska A et al (1982) A preliminary report on the clinical application of fast neutrons in Krakow. Int J Radiat Oncol Biol Phys 8:1781–1786
Huber PE, Debus J, Latz D et al (2001) Radiotherapy for advanced adenoid cystic carcinoma: neutrons, photons or mixed beam? Radiother Oncol 59:161–167
Mizoe JE, Hasegawa A, Bessho H et al (2009) Head and neck tumors. Proceedings of NIRS ETOILE Joint Symposium 2009 on Carbon Ion Radiotherapy, Lyon
Igaki H Tokuuye K, Okumura T et al (2004) Clinical results of proton beam therapy for skull base chordoma. Int J Radiat Oncol Biol Phys 60:1120–1126
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Orecchia, R., Krengli, M., Fossati, P. (2011). Adroterapia. In: Tumori della testa e del collo. Springer, Milano. https://doi.org/10.1007/978-88-470-1806-8_13
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DOI: https://doi.org/10.1007/978-88-470-1806-8_13
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