Abstract
The category of diffuse liver diseases includes a variety of disorders that typically involve the liver in a non-focal fashion. It is important to note, however, that even within this group there may be focal abnormalities, representing unusual expression of a disease that typically has a diffuse manifestation. At the same time there may be focal neoplasms, some of which are benign and others malignant. With recent advances in cross sectional imaging, the detection, characterization, and follow-up of diffuse liver disease has been greatly facilitated.
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General
Boll DT, Merkle EM (2009) Diffuse liver disease: Strategies for hepatic CT and MR imaging. Radiographics 29:1591–1614
Cohen EI, Wilck EJ, Shapiro RS (2006) Hepatic imaging in the 21st century. Semin Liver Dis 26:363–372
Foley WD, Jochem RJ (1991) Computed tomography: Focal and diffuse liver disease. Radiol Clin North Am 29:1213–1233
Gourtsoyiannis NC, Ros PR (eds) (2005) Radiologic-pathologic correlations from head to toe: Understanding the manifestations of disease, Springer-Verlag, Berlin, Heidelberg
Mergo PJ, Ros PR (1998) Imaging of diffuse liver disease. Radiol Clin North Amer 36:365–375
Mergo PJ, Ros PR, Buetow PC, Buck JL (1994) Diffuse diseases of the liver: Radiologic-pathologic correlation. Radiographics 14:1291–1307
Mitchell DG (1992) Focal manifestations of diffuse liver disease at MR imaging. Radiology 185:1–11
Mortele KJ, Ros PR (2001) Imaging of diffuse liver disease. Semin Liver Dis 21:195–212
Rofsky NM, Fleishaker H (1995) CT and MRI of diffuse liver disease. Semin Ultrasound, CT, and MRI 16:16–33
Ros PR (1997) MR imaging of the liver. In: Magn Reson Imag Clin North Amer, Vol 5, WB Saunders, Philadelphia, PA
Ros PR (1998) Hepatic imaging. In: Radiol Clin North Amer, WB Saunders, Philadelphia, PA
Ros PR (2002) Hepatic imaging and intervention. In: Clinics in Liver Disease, WB Saunders, Philadelphia, PA
Ros PR, Mortele K (2006) CT/MRI of the Abdomen and Pelvis, Lippincott, Williams and Wilkins, Philadelphia, PA
Fibrous Tissue Deposition (Cirrhosis)
Aguirre DA, Behling CA, Alpert E et al (2006) Liver fibrosis: Noninvasive diagnosis with double contrast material-enhanced MR imaging. Radiology 239:425–437
Awaya H, Mitchell DG, Kamishima T et al (2002) Cirrhosis: Modified caudate-right lobe ratio. Radiology 224:769–774
Blachar A, Federle MP, Brancatelli G (2001) Primary biliary cirrhosis: Clinical, pathologic, and helical CT findings in 53 patients. Radiology 220:329–336
Bryce TJ, Yeh BJ, Qayyum A et al (2003) CT signs of hepatofugal venous flow in patients with cirrhosis. AJR Am J Roentgenol 181:1629–1633
Cobbold JF, Wylezinska M, Cunningham C et al (2006) Non-invasive evaluation of hepatic fibrosis using magnetic resonance imaging and ultrasound techniques. Gut 55:1670–1672
Colli A, Fraquelli M, Andreoletti M et al (2003) Severe liver fibrosis or cirrhosis: Accuracy of US for detection: Analysis of 300 cases. Radiology 227:89–94
Day CP (2006) From fat to inflammation. Gastroenterology 130: 207–210
Dodd GD III, Baron RL, Oliver JH III et al (1999) End-stage primary sclerosing cholangitis: CT findings of hepatic morphology in 36 patients. Radiology 211:357–362
Dodd GD, Oliver JH, Federle MP et al (1993) Spectrum of imaging findings in hepatic cirrhosis: Pathologic correlation in 500 complete hepatectomy specimens. Radiology 189:421
Faria SC, Ganesan K, Mwangi I et al (2009) MR imaging of liver fibrosis: Current state of the art. Radiographics 29: 1615–1635
Friedman SL, Rockey DC, Bissell DM (2007) Hepatic fibrosis 2006: Report of the third AASLD single topic conference. Hepatology 45:242–249
Hussain S, Reinhold C, Mitchell DG (2009) Cirrhosis and lesion characterization at MR imaging. Radiographics 29:1637–1652
Ito K, Mitchell DG, Gabata T et al (1999) Expanded gallbladder fossa: Simple MR imaging sign of cirrhosis. Radiology 211: 723–726
Johnson KJ, Olliff JF, Olliff SP (1998) The presence and significance of lymphadenopathy detected by CT in primary sclerosing cholangitis. Br J Radiol 71:1279–1282
Kang HK, Jeong YY, Choi JH et al (2002) Three-dimensional multidetector row CT portal venography in the evaluation of portosystemic collateral vessels in liver cirrhosis. Radiographics 22:1053–1061
Kim M-J, Mitchell DG, Ito K (2000) Portosystemic collaterals of the upper abdomen: Review of anatomy and demonstration on MR imaging. Abdom Imaging 25:462–470
Kim YJ, Raman SS, Yu NC et al (2007) Esophageal varices in cirrhotic patients: Evaluation with liver CT. AJR Am J Roentgenol 188:139–144
Lee V (2006) Can MR imaging replace liver biopsy for the diagnosis of early fibrosis? Radiology 239:309–310
Lipson JA, Qayyum A, Avrin DE et al (2005) CT and MRI of hepatic contour abnormalities. AJR Am J Roentgenol 184: 75–81
Mortele KJ, Ros PR (2002) MR Imaging in chronic hepatitis and cirrhosis. Semin in Ultrasound, CT, and MRI 23:79–100
Ohtomo K, Baron RL, Dodd GD et al (1993) Confluent hepatic fibrosis in advanced cirrhosis: Appearance at CT. Radiology 188:31–35
Revelon G, Rashid A, Kawamoto S et al (1999) Primary sclerosing cholangitis MR imaging findings with pathologic correlation. AJR Am J Roentgenol 173:1037–1042
Rouviere O, Yin M, Dresner MA et al (2006) MR elastography of the liver: Preliminary results. Radiology 240:440–673
Vascular Disorders
Abu-Yousef MM, Milam SG, Farner RM (1990) Pulsatile portal vein flow: A sign of tricuspid regurgitation on duplex Doppler sonography. AJR Am J Roentgenol 155:785–788
Arai K, Matsui O, Takashima T et al (1988) Focal spared areas in fatty liver caused by regional decreased portal flow. AJR Am J Roentgenol 151:300–302
Bargallo X, Gilabert R, Nicolau C et al (2003) Sonography of the caudate vein: Value in diagnosing Budd-Chiari syndrome. AJR Am J Roentgenol 181:1641–1645
Bradbury MS, Kavanaugh PV, Bechtold RE et al (2002) Mesenteric venous thrombosis: Diagnosis and noninvasive imaging. Radiographics 22:527–541
Brancatelli G, Federle MP, Grazioli L et al (2002) Large regenerative nodules in Budd-Chiari syndrome and other vascular disorders of the liver: CT and MR findings with clinicopathologic correlation. AJR Am J Roentgenol 178:877–883
Camera L, Mainenti PP, Di Giacomo A et al (2006) Triphasic helical CT in Budd-Chiari syndrome: Patterns of enhancement in acute, subacute and chronic disease. Clin Radiol 61: 331–337
Cazals-Hatem D, Vilfrain V, Genin P et al (2003) Arterial and portal circulation and parenchymal changes in Budd-Chiari syndrome: A study in 17 explanted livers. Hepatology 37: 510–519
Colegrande S, Centi N, Galdiero R et al (2007) Transient hepatic intensity differences: Part 1. Those associated with focal lesions. AJR Am J Roentgenol 188:154–159
Colegrande S, Centi N, Galdiero R et al (2007) Transient hepatic intensity differences: Part 2. Those not associated with focal lesions. AJR Am J Roentgenol 188:160–166
Erden A (2007) Budd-Chiari syndrome: A review of imaging findings. Eur J Radiol 61:44–56
Erden A, Erden I, Krayalcin S et al (2002) Budd-Chiari syndrome: Evaluation with multiphase contrast-enhanced threedimensional MR angiography. AJR Am J Roentgenol 179: 1287–1292
Gallego C, Velasco M, Marcuello P et al (2002) Congenital and acquired anomalies of the portal venous system. Radiographics 22:141–159
Gore RM, Mathieu DG, White EM et al (1994) Passive hepatic congestion: Cross-sectional imaging features. AJR Am J Roentgenol 162:71–75
Harter LP, Gross BH, St Hilaire J et al (1982) CT and sonographic appearance of hepatic vein obstruction. AJR Am J Roentgenol 139:176–178
Iannaccone R, Federle MP, Brancatelli G et al (2006) Peliosis hepatis: Spectrum of imaging findings. AJR Am J Roentgenol 187:W43–W52
Kane R, Eustace S (1995) Diagnosis of Budd-Chiari syndrome: Comparison between sonography and MR angiography. Radiology 195:117–121
Kim HJ, Kim AY, Kim TK et al (2005) Transient hepatic attenuation differences in focal hepatic lesions: Dynamic CT features. AJR Am J Roentgenol 184:83–90
Mathieu D, Vasile N, Menu Y et al (1987) Budd-Chiari syndrome: Dynamic CT. Radiology 165:409–413
Moore EH, Russell LA, Klein JS et al (1995) Bacillary angiomatosis in patients with AIDS: multiorgan imaging findings. Radiology 197:67–72
Pliskin M (1975) Peliosis hepatis. Radiology 114:29–30
Rossi S, Rosa L, Ravetta V et al (2006) Contrast-enhanced versus conventional and color Doppler sonography for the detection of thrombosis of the portal and hepatic venous systems. AJR Am J Roentgenol 186:763–773
Sandrasegaran K, Hawes DR, Matthew G (2005) Hepatic peliosis (bacillary angiomatosis) in AIDS: CT findings. Abdom Imaging 30:738–740
Metabolic and Storage Diseases
Kawamori Y, Matsui O, Takahashi S et al (1996) Focal hepatic fat infiltration in the posterior edge of the medial segment associated with aberrant gastric venous drainage: CT, US, and MR findings. J Comput Assist Tomogr 17:590–595
Ko S, Lee T, Ng S et al (1998) Unusual liver MR findings of Wilson’s disease in an asymptomatic 2-year-old girl. Abdom Imaging 23:56–59
Marmoloya G, Karlins NL, Petrelli M, McCullough A (1990) Unusual computed tomography findings in hepatic amyloidosis. Clin Imaging 14:248
Queiroz-Andrade M, Blasbalg R, Ortega CD et al (2009) MR imaging findings of iron overload. Radiographics 29: 1575–1589
Siegelman ES, Mitchell DG, Semelka RC (1996) Abdominal iron deposition: metabolism, MR findings, and clinical importance. Radiology 199:13–22
Infectious Diseases
Akhan O, Ozmen MN, Dincer A et al (1996) Liver hydatid disease: long-term results of percutaneous treatment. Radiology 198:259–264
Balci NC, Sirvanci M (2002) MR imaging of infective liver lesions. Magn Reson Imaging Clin N Am 10:121–135
Cheung H, Lai YM, Loke TK et al (1996) The imaging diagnosis of hepatic schistosomiasis japonicum sequelae. Clin Radiol 51:51–55
Czermak BV, Unsinn KM, Gotwald T et al (2001) Echinococcus multilocularis revisited. AJR Am J Roentgenol 176:207–1212
Danon O, Duval-Arnould M, Osman Z et al (2002) Hepatic and splenic involvement in cat-scratch disease: imaging features. Abdom Imaging 25:182–183
Doyle DJ, Hanbidge AE, O’Malley ME (2006) Imaging of hepatic infections. Clin Radiol 61(9):737–748
Giorgio A, Tarantino L, Mariniello N et al (1995) Pyogenic liver abscesses: 13 years of experience in percutaneous needle aspiration with US guidance. Radiology 195:122–124
Hickey N, McNulty JG, Osborne H, Finucane J (1999) Acute hepatobiliary tuberculosis: A report of two cases and a review of the literature. Eur Radiol 9:886–889
Jeffrey RB, Tolentino CS, Chang FC et al (1998) CT of small pyogenic hepatic abscesses: the cluster sign. AJR Am J Roentgenol 151:487–489
Kalovidouris A, Gouliamos A, Vlachos L et al (1994) MRI of abdominal hydatid disease. Abdom Imaging 19:489–494
Lee TY, Wan YL, Tsai CC (1994) Gas-containing liver abscess: Radiological findings and clinical significance. Abdom Imaging 19:46–52
Mendez RJ, Schiebler ML, Outwater EK et al (1994) Hepatic abscesses: MR imaging findings. Radiology 190:431–436
Monzawz S, Ohtomo K, Oba H et al (1994) Septa in the liver of patients with chronic hepatic schistosomiasis japonica: MR appearance. AJR Am J Roentgenol 162:1347–1351
Mortele KJ, Segatto E, Ros PR (2004) The infected liver: radiologic-pathologic correlation. Radiographics 24:937–955
Pastakia B, Shawker TH, Thaler M et al (1988) Hepatosplenic candidiasis: wheels within wheels. Radiology 166:417–444
Ralls PW (2002) Inflammatory disease of the liver. Clin Liver Dis 6:203–225
Ralls PW, Henley DS, Colletti PM et al (1987) Amebic liver abscess: MR imaging. Radiology 165:801–804
Rappaport DC, Cumming WA, Ros PR (1991) Disseminated hepatic and splenic lesions in cat-scratch disease: Imaging features. AJR Am J Roentgenol 156:1227–1228
Ros PR, Sobin LH (1994) Amyloidosis: The same cat, with different stripes. Radiology 190:14–15
Ros PR, Ertuk SM (2007) Focal hepatic infections. In: Gore RM, Levine MS (eds) Textbook of Gastrointestinal Radiology, 3rd edn. WB Saunders, Philadelphia, PA, pp 1663–1684
Sakai T, Maeda M, Takabatake M et al (1995) MR imaging of hepatosplenic sarcoidosis. Radiat Med 13:39–41
Taourel P, Marty-Ane B, Charasset S et al (1993) Hydatid cyst of the liver: comparison of CT and MRI. J Comput Assist Tomogr 17:80–85
Van Allen RJ, Katz MD, Johnson MB et al (1992) Uncomplicated amebic liver abscess: prospective evaluation of percutaneous therapeutic aspiration. Radiology 183:827–830
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Ros, P.R., Nelson, R.C. (2010). Imaging of Diffuse and Inflammatory Liver Diseases. In: Hodler, J., Zollikofer, C.L., Von Schulthess, G.K. (eds) Diseases of the Abdomen and Pelvis 2010–2013. Springer, Milano. https://doi.org/10.1007/978-88-470-1637-8_8
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DOI: https://doi.org/10.1007/978-88-470-1637-8_8
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