Skip to main content
SpringerLink
Log in

Ultrasound Contrast Agent Microbubble Dynamics

  • Chapter
Ultrasound Contrast Agents

Abstract

Ultrasound contrast agents are traditionally used in ultrasound-assisted organ perfusion imaging. Recently the use of coated microbubbles has been proposed for molecular imaging applications where the bubbles are covered with a layer of targeting ligands to bind specifically to their target cells. In this chapter we describe contrast agent microbubble behavior starting from the details of free bubble dynamics leading to a set of equations describing the dynamics of coated microbubbles. Experimentally, the dynamics of ultrasound contrast agent microbubbles is temporally resolved using the ultra-high speed camera Brandaris 128. The influence of a neighboring wall is investigated by combining the Brandaris camera with optical tweezers. It was observed that the presence of the wall can alter the bubble response. A detailed description of the bubble-wall interaction may therefore lead to improved molecular imaging strategies.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Ashkin A (1986) Observation of a single-beam gradient force optical trap for dielectric particles. Optics Letters 11(5):288

    Article  Google Scholar 

  2. Bjerknes V (1906) Fields of Force. Columbia University Press

    Google Scholar 

  3. Brock-Fisher G, Poland M and Rafter P (1996) Means for increasing sensitivity in non-linear ultrasound imaging systems US patent no 55775

    Google Scholar 

  4. Chetty K, Stride E, Sennoga C, Hajnal J and Eckersley R (2008) High-speed optical observations and simulation results of sonovue microbubbles at lowpressure insonation. IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control 55(6):1333–1342

    Article  Google Scholar 

  5. Chin C, Lancee C, Borsboom J, Mastik F, Frijlink M, de Jong N, Versluis M and Lohse D (2003) Brandaris 128: A digital 25 million frames per second camera with 128 highly sensitive frames. Review of Scientific Instruments 74:5026–5034

    Article  Google Scholar 

  6. Church C (1995) The effects of an elastic solid surface layer on the radial pulsations of gas bubbles. The Journal of the Acoustical Society of America 97(3):1510–1521

    Article  Google Scholar 

  7. De Jong N, Cornet R and Lancee CT (1994) Higher harmonics of vibrating gas-filled microspheres. part one: simulations. Ultrasonics 32:447–453

    Article  Google Scholar 

  8. De Jong N, Emmer M, Chin C, Bouakaz A, Mastik F, Lohse D and Versluis M (2007) “compression-only” behavior of a phosphorlipid-coated contrast bubbles. Ultrasound in Medicine and Biology 33(4)

    Google Scholar 

  9. Doinikov A (2001) Translational motion of two interacting bubbles in a strong acoustic field. Physical Review E 64(2):026,301

    Article  Google Scholar 

  10. Emmer M, Wamel AV, Goertz D and Jong ND (2007) The onset of microbubble vibration. Ultrasound in Medicine and Biology 33(6):941–949

    Article  Google Scholar 

  11. Flynn H (1975a) Cavitation dynamics. i. a mathematical formulation. The Journal of the Acoustical Society of America 57(6):1379–1396

    Article  MATH  Google Scholar 

  12. Flynn H (1975b) Cavitation dynamics: Ii. free pulsations and models for cavitation bubbles. The Journal of the Acoustical Society of America 58(6):1160–1170

    Article  Google Scholar 

  13. Gahagan K (1996) Optical vortex trapping of particles. Optics Letters 21(827):11

    Google Scholar 

  14. Garbin V, Cojoc D, Ferrari E, Fabrizio ED, Overvelde M, van der Meer S, de Jong N, Lohse D and Versluis M (2007) Changes in microbubble dynamics near a boundary revealed by combined optical micromanipulation and highspeed imaging. Applied Physics Letters 90:114,103

    Article  Google Scholar 

  15. Gilmore F (1952) The growth or collapse of a spherical bubble in a viscous compressible liquid. Tech. rep., Hydrodynamics Laboratory, California Institute Technology, Pasadena, report 26-4

    Google Scholar 

  16. Gorce JM, Arditi M and Schneider M (2000) Influence of bubble size distribution on the echogenicity of ultrasound contrast agents. Investigative Radiology 35(11):661–671

    Article  Google Scholar 

  17. Herring C (1941) Theory of the pulsations of the gas bubble produced by an underwater explosion. Tech. rep., OSRD report 236

    Google Scholar 

  18. Hoff L, Sontum P and Hovem J (2000) Oscillations of polymeric microbubbles: Effect of the encapsulating shell. The Journal of the Acoustical Society of America 107(4):2272–2280

    Article  Google Scholar 

  19. Hope Simpson D, Ting CC and Burns P (1999) Pulse inversion doppler: a new method for detecting nonlinear echoes from microbubble contrast agents. IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control 46(2):372–382

    Article  Google Scholar 

  20. Keller J and Kolodner I (1956) Damping of underwater explosion bubble oscillations. Journal of Applied Physics 27(10):1152–1161

    Article  Google Scholar 

  21. Keller JB and Miksis M (1980) Bubble oscillations of large amplitude. The Journal of the Acoustical Society of America 68:628–633

    Article  MATH  Google Scholar 

  22. Klibanov A (2002) Ultrasound Contrast Agents: Development of the Field and Current Status, Topics in Current Chemistry 222

    Google Scholar 

  23. Lankford M, Behm C, Yeh J, Klibanov A, Robinson P and Linder J (2006) Effect of microbubble ligation to cells on ultrasound signal enhancement: implications for targeted imaging. Investigative Radiology 41(10)

    Google Scholar 

  24. Lauterborn W (1976) Numerical investigation of nonlinear oscillations of gas bubbles in liquids. The Journal of the Acoustical Society of America 59(2):283–293

    Article  Google Scholar 

  25. Leighton T (1994) The Acoustic Bubble. Academic Press Inc. San Diego

    Google Scholar 

  26. Marmottant P, van der Meer S, Emmer M, Versluis M, de Jong N, Hilgenfeldt S and Lohse D (2005) A model for large amplitude oscillations of coated bubbles accounting for buckling and rupture. The Journal of the Acoustical Society of America 118:3499–3505

    Article  Google Scholar 

  27. Marmottant P, Versluis M, Jong ND, Hilgenfeldt S and Lohse D (2006) Highspeed imaging of an ultrasound-driven bubble in contact with a wall: “narcissus” effect and resolved acoustic streaming. Experiments in Fluids 41(2):147–153

    Article  Google Scholar 

  28. Minnaert M (1933) On musical air-bubbles and sounds of running water. Philosophical Magazine 16:235–248

    Google Scholar 

  29. Neppiras E and Noltingk B (1951) Cavitation produced by ultrasonics: Theoretical conditions for the onset of cavitation. Proceedings of the Physical Society Section B 64(12):1032–1038

    Article  Google Scholar 

  30. Noltingk B and Neppiras E (1950) Cavitation produced by ultrasonics. Proceedings of the Physical Society Section B 63(9):674–685

    Article  Google Scholar 

  31. Plesset M (1949) The dynamics of cavitation bubbles. Journal of Applied Mechanics 16:277–282

    Google Scholar 

  32. Poritsky H (1952) The collapse or growth of a spherical bubble or cavity in a viscous fluid. Proceedings of the first US National Congress on Applied Mechanics pp 813–821

    Google Scholar 

  33. Prosperetti A (1975) Nonlinear oscillations of gas bubbles in liquids. transient solutions and the connection between subharmonic signal and cavitation. The Journal of the Acoustical Society of America 57(4):810–821

    Article  Google Scholar 

  34. Prosperetti A, Crum L and Commander K (1988) Nonlinear bubble dynamics. The Journal of the Acoustical Society of America 83(2):502–514

    Article  Google Scholar 

  35. Rayleigh L (1917) On the pressure developed in a liquid during the collapse of a spherical cavity. Philosophical Magazine 34:94–98

    Google Scholar 

  36. Sarkar K, Shi W, Chatterjee D and Forsberg F (2005) Characterization of ultrasound contrast microbubbles using in vitro experiments and viscous and viscoelastic interface models for encapsulation. The Journal of the Acoustical Society of America 118(1):539–550

    Article  Google Scholar 

  37. Trilling L (1952) The collapse and rebound of a gas bubble. Journal of Applied Physics 23(1):14–17

    Article  MathSciNet  Google Scholar 

  38. Van der Meer S, Dollet B, Chin CT, Bouakaz A, Voormolen M, de Jong N, Versluis M and Lohse D (2007) Microbubble spectroscopy of ultrasound contrast agents. The Journal of the Acoustical Society of America 120:3327–3327

    Google Scholar 

  39. Vos H, Dollet B, Bosch J, Versluis M and de Jong N (2008) Nonspherical vibrations of microbubbles in contact with a wall — a pilot study at low mechanical index. Ultrasound in Medicine and Biology 34(4):685–688

    Google Scholar 

  40. Zhao S, Ferrara K and Dayton P (2005) Asymmetric oscillation of adherent targeted ultrasound contrast agents. Applied Physics Letters 87(13)

    Google Scholar 

  41. Zhao S, Kruse D, Ferrara K and Dayton P (2006) Acoustic response from adherent targeted contrast agents. The Journal of the Acoustical Society of America 120(6):EL63–EL69

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Physics of Fluids Group, University of Twente, The Netherlands

    Marlies Overvelde & Michel Versluis

  2. Biomedical Engineering, Thorax Centre, Erasmus MC, Rotterdam, The Netherlands

    Hendrik J. Vos & Nico de Jong

Authors
  1. Marlies Overvelde
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Hendrik J. Vos
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Nico de Jong
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Michel Versluis
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Dipartimento di Scienze e Tecnologie Chimiche, Università di Roma Tor Vergata, Rome, Italy

    Gaio Paradossi

  2. Esaote — R & D Ultrasuoni, Genoa, Italy

    Paolo Pellegretti

  3. Acoustics, Antenna Arrays, and Underwater Signals Lab. Dept. of Biophysical and Electronic Engineering (DIBE), University of Genoa, Genoa, Italy

    Andrea Trucco

Rights and permissions

Reprints and permissions

Copyright information

© 2010 Springer-Verlag Italia

About this chapter

Cite this chapter

Overvelde, M., Vos, H.J., de Jong, N., Versluis, M. (2010). Ultrasound Contrast Agent Microbubble Dynamics. In: Paradossi, G., Pellegretti, P., Trucco, A. (eds) Ultrasound Contrast Agents. Springer, Milano. https://doi.org/10.1007/978-88-470-1494-7_7

Download citation

  • DOI: https://doi.org/10.1007/978-88-470-1494-7_7

  • Publisher Name: Springer, Milano

  • Print ISBN: 978-88-470-1493-0

  • Online ISBN: 978-88-470-1494-7

  • eBook Packages: EngineeringEngineering (R0)

Publish with us

Policies and ethics

Search

Navigation