Abstract
Rubella: Salient Points
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Congenital rubella (CR) infection leads to damage in over 80% of fetuses during the first trimester of pregnancy, in 25–34% of cases in the second trimester, while no malformations occur in the third trimester.
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CR syndrome (CRS) is characterized by the combination of cardiac, ocular, and hearing defects, although any organ may be affected leading to long-term disabilities.
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To prevent CRS it is essential to verify before or during pregnancy, that all women have natural or vaccine-induced immunity to the rubella virus.
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References
Robertson SE, Featherstone DA, Gacic-Dobo M et al (2003) Rubella and congenital rubella syndrome: global update. Pan Am J Public Health 14: 306–315
Duszak RS (2009) Congenital rubella syndrome-major review. Optometry 80: 36–43
Best JM (2007) Rubella. Semin Fetal Neonatal Med 12: 182–192
Kourtis AP, Schmid CH, Jamieson DJ, Lau J (2007) Use of antiretroviral therapy in pregnant HIV-infected women and the risk of premature delivery: a meta-analysis. AIDS 21: 607–615
Centers for Disease Control and Prevention (1994) Revised classification system for human immunodeficiency virus infection in children less than 13 years of age. MMWR Recomm Rep 43: 1–20
European Collaborative Study (2005) Mother-to-child transmission of HIV infection in the era of highly active antiretroviral therapy. Clin Infect Dis 40: 458–465
Perinatal HIV Guidelines Working Group (2009) Recommendations for use of antiretroviral drugs in pregnant HIV-infected women for maternal health and interventions to reduce perinatal HIV transmission in the United States. http://aidsinfo.nih.gov/ContentFiles/ PerinatalGL.pdf
Chiappini E, Galli L, Gabiano C et al (2006) Early triple therapy vs mono or dual therapy for children with perinatal HIV infection. JAMA 295: 626–628
John-Stewart GC (2009) Strategic approaches to decrease breast milk transmission of HIV-1: the importance of small things. J Infect Dis 200: 1487–1489
Working Group on Antiretroviral Therapy and Medical Management of HIV-Infected Children (2009) Guidelines for the use of antiretroviral agents in pediatric HIV infection. http://aidsinfo.nih.gov/ContentFiles/PediatricGuidelines.pdf
Centers for Disease Control and Prevention (1999) Guidelines for national human immunodeficiency virus case surveillance, including monitoring for human immunodeficiency virus infection and acquired immunodeficiency syndrome. MMWR Recomm Rep 48: 1–13
Mofenson LM, Brady MT, Danner SP et al (2009) Guidelines for the prevention and treatment of opportunistic infections among HIV-exposed and HIV-infected children. MMWR Recomm Rep 58: 1–166
Pembrey L, Newell ML, Tovo PA; EPHN Collaborators (2005) The management of HCV infected pregnant women and their children European paediatric HCV network. J Hepatol 43: 515–525
Indolfi G, Resti M (2009) Perinatal transmission of hepatitis C virus infection. J Med Virol 81: 836–843
Tovo PA, Lazier L, Versace A (2005) Hepatitis B virus and hepatitis C virus infections in children. Curr Opin Infect Dis 18: 261–266
Polywka S, Pembrey L, Tovo PA, Newell ML (2006) Accuracy of HCV-RNA PCR test for diagnosis or exclusion of vertically acquired HCV infection. J Med Virol 78: 305–310
Davidson SM, Mieli-Vergani G, Sira J, Kelly DA (2006) Perinatal hepatitis C virus infection: diagnosis and management. Arch Dis Child 91: 781–785
Davidson SM, Kelly DA (2008) Management strategies for hepatitis C virus infection in children. Pediatr Drugs 10: 357–365
Jara P, Hierro L, de la Vega A et al (2008) Efficacy and safety of peginterferon-alpha2b and ribavirin combination therapy in children with chronic hepatitis C infection. Pediatr Infect Dis J 27: 142–148
Hsu EK, Murray KF (2008) Hepatitis B and C in children. Nat Clin Pract Gastroenterol Hepatol 5: 311–320
Haber BA, Block JM, Jonas MM et al (2009) Recommendations for screening, monitoring and referral of pediatric chronic hepatitis B. Pediatrics 124: 1007–1014
Kurbegov AC, Sokol RJ (2009) Hepatitis B therapy in children. Expert Rev Gastroenterol Hepatol 3: 39–49
de Jong EP, de Haan TR, Kroes AC et al (2006) Parvovirus B19 infection in pregnancy. J Clin Virol 36: 1–7
Heegaard ED, Brown KE (2002) Human Parvovirus B19. Clin Microbiol Rev 15: 485–505
www.hepfi.org/pdfs/PegIntron%20and%20Rebetol%20FDA%20Approved_for%20Pediatric%20HCV%2012.12.08.pdf
Pawlowska M, Halota W (2007) Rapid viral response during treatment of chronic hepatitis B with pegylated interferon alfa-2a in children–preliminary report. Przegl Epidemiol 61: 427–431
Sokal EM, Conjeevaram HS, Roberts EA et al (1998) Interferon alfa therapy for chronic hepatitis B in children: a multinational randomized controlled trial. Gastroenterology 114: 988–995
Jonas M, Mizerski J, Badia IB et al (2002) Clinical trial of lamivudine in children with chronic hepatitis B. N Engl J Med 346: 1706–1713
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Tovo, PA., Bezzio, S., Gabiano, C. (2012). Fetal infections: Rubella, HIV, HCV, HBV, and Human Parvovirus B19. In: Buonocore, G., Bracci, R., Weindling, M. (eds) Neonatology. Springer, Milano. https://doi.org/10.1007/978-88-470-1405-3_113
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