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Thyroid-Hormone-Regulated Cardiac Metabolism in Normal and Failing Heart

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Thyroid and Heart Failure

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Abstract

Thyroid hormones regulate multiple metabolic processes in cardiomyocytes that can impact the failing heart. Recent data suggest that thyroid hormone receptors play an important role in nongenomic regulation as well as in transcription. Myocardial energy metabolism shows a balance between ATP production and utilization. Thyroid hormone regulates this balance through multiple processes. Accordingly, thyroid hormone can control the cellular environment by modifying the cellular energy state, which in turn influences processes such as transport and protein synthesis. Here we review thyroid hormone’s direct action on metabolism and ligand-dependent control through the nuclear receptors.

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Authors and Affiliations

  1. University of Washington and Seattle Children’s Hospital, Seattle, WA, USA

    Michael A. Portman MD

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  1. Michael A. Portman MD
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  1. C.N.R. Clinical Physiology Institute, S. Cataldo Research Campus, Pisa, Italy

    Giorgio Iervasi  & Alessandro Pingitore  & 

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Portman, M.A. (2009). Thyroid-Hormone-Regulated Cardiac Metabolism in Normal and Failing Heart. In: Iervasi, G., Pingitore, A. (eds) Thyroid and Heart Failure. Springer, Milano. https://doi.org/10.1007/978-88-470-1143-4_11

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  • DOI: https://doi.org/10.1007/978-88-470-1143-4_11

  • Publisher Name: Springer, Milano

  • Print ISBN: 978-88-470-1142-7

  • Online ISBN: 978-88-470-1143-4

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