Abstract
The structure and properties of a specific hydrogel are extremely important in selecting which materials are suitable for the specific application. Knowledge of the structure-property relationship is, then, fundamental to tailor hydrogel properties to their final goal.
In this chapter, the theory describing the mechanical, both static and dynamic, and the swelling behavior of hydrogels is examined and the relationship between these properties and structural parameters is discussed.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Peppas NA, Huang Y et al (2000) Physicochemical foundations and structural design of hydrogels in medicine and biology. Annu Rev Biomed Eng 02:9–29
Peppas NA (1986) Hydrogels in medicine and pharmacy. CRC Press, Boca Raton, Florida.
Sperling LH (1981) Interpenetrating polymer Networks. Plenum Press, New York
Ratner BD, Hoffman AS (1976) Synthetic hydrogels for biomedical applications. In: Andrade JD (ed) Hydrogels for medical and related applications. ACS symposium series, 31, ACS Washington
Park H, Park K, Shalaby Waleed SW (1993) Biodegradable Hydrogels for Drug Delivery. CRC Press, Boca Raton, Florida
Borzacchiello A, Ambrosio L, Netti PA, Nicolais L (2004 ) Rheology of biological fluids and their substitute. In: Yaszemski MJ, Trantolo DJ, Lewandroski KU, Hasirci V, Altobelli DE, Wise DL (ed), Tissue Engineering and Novel Drug Delivery Systems. Marcel Dekker Inc, New York
Ross-Murphy SB (1991) Physical gelation of synthetic and biological macromolecules. In: De Rossi D, Kajiwara K, Osada Y and Yamauchi A (ed) Polymer Gels. Fundamentals and Biomedical Applications. Plenum Press, New York
Clark AH, Ross-Murphy SB (1987) Structural and mechanical properties of biopolymers gels. Adv Pol Sc 83:61
Brannon-Peppas L (1994) Preparation and characterization of cross-linked hydrophilic networks. In: Superabsorbent Polymers: Science and Technology ACS Symp. Ser. 573, American Chemical Society, Washington, DC
Peppas NA, Mikos AG (1986) Preparation methods and structure of hydrogels. In: Peppas NA (ed) Hydrogels in Medicine and Pharmacy, Vols 1,2. CRC press Boca Raton, Florida
Peppas NA, Barr-Howell BD (1986) Characterization of the cross-linked structure of hydrogels. In: Peppas NA (ed) Hydrogels in Medicine and Pharmacy, Vols 1,2. CRC press Boca Raton, Florida
Peppas NA, Huang Y, Torres-Lugo M, Ward JH, Zhang J (2000) Physicochemical foundations and structural design of hydrogels in medicine and biology. Annu Rev Biomed Eng 02:9–29
Anseth KS et al. (1996) Mechanical properties of hydrogels and their experimental determination. Biomaterials 17:1647–1657
Ferry JD (1970) Viscoelastic Properties of Polymers. Wiley, New York
Ambrosio L, Borzacchiello A, Netti PA, Nicolais L (1998) Rheological properties of hyaluronic acid based solutions. Polymeric Materials Science and Engineering 79: 244–245
Ambrosio L, Borzacchiello A., Netti PA, Nicolais L (1999) Rheological study on Hyaluronic acid and its derivatives solutions. J. of Macromolecular Science-Pure and Applied Chemistry A36(7 and 8):991–1000
Borzacchiello A, Netti PA, Ambrosio L, Nicolais L (2000) Hyaluronic acid derivatives mimic the rheological properties of vitreous body. In: Abatangelo G, Weigel PH (ed) New Frontiers in Medical Sciences: Redefining Hyaluronan. Elsevier, Amsterdam, pp 195–202
Borzacchiello A, Ambrosio L (2001) Network formation of low molecular weight hyaluronic acid derivatives. Journal of Biomaterials Science Polymer Edition 12(3):307–316
Maltese A, Bucolo C, Maugeri F, Borzacchiello A, Mayol L, Nicolais L, Ambrosio L (2006) Novel polysaccharides based viscoelastic formulations for ophthalmic surgery: rheological characterization. Biomaterials 27:5134–5142
Barbucci R, Ruoppoli R, Borzacchiello A, Ambrosio L (2000) Synthesis, chemical and rheological characterisation of new hyaluronic based hydrogels. Journal of Biomaterials Science Polymer Edition 11(4):383–399
Borzacchiello A, Ambrosio L, Netti PA, Nicolais L, Peniche C, Gallardo A, San Roman J (2001) Chitosan-based hydrogels: Synthesis and Characterization. J. of Materials Science: Materials in Medicine 12:861–864
Barbucci R, Lamponi S, Borzacchiello A, Ambrosio L, Fini M, Torricelli P, Giardino R (2002) Hyaluronic acid hydrogel in the treatment of osteoarthritis. Biomaterials 23(13): 4503–4513
Leone G, Barbucci R, Borzacchiello A, Ambrosio L, Netti PA, Migliaresi C (2004) Preparation and physico-chemical characterisation of microporous polysaccharide hydrogels. J Mater Sci Mater in Med 15(4):463–467
Borzacchiello A, Mayol L, Ramires PA, Di Bartolo C, Pastorello A, Ambrosio L, Milella E (2007) Structural and rheological characterization of hyaluronic acid-based scaffolds for adipose tissue engineering. Biomaterials 28:4399–4408
D’Errico G, De Lellis M, Mangiapia G, Ortona O, Fusco S, Borzacchiello A, Ambrosio L (2008) Structural and mechanical properties of UV photocrosslinked poly(N-vinyl-2-pyrrolidone) hydrogels. Biomacromolecules 9(1): 231–240
Xuejun Xin, Borzacchiello A, Netti PA, Ambrosio L, Nicolais L (2004) Hyaluronic Acid Based Semi Interpenetrating Materials. J Biomater Sci Polymer Edn 15:1223–1236
Battista S, Guarnieri D, Borselli C, Zeppetelli S, Borzacchiello A, Mayol L, Gerbasio D, Keene DR, Ambrosio L, Netti PA (2005) The effect of matrix composition of 3D constructs on embryonic stem cell differentiation. Biomaterials 26(31):6194–6207
Guarnirei D, Battista S, Borzacchiello A, Mayol L, De Rosa E, Kene DR, Muscariello L, Barbarisi A, Netti PA (2007) Effect of fibronectin and laminin on structural, mechanical and transoprt properties of 3D collageneous network. Journal of Materials Science: Materials in Medicine 18(2): 245–253
Lapasin R, Pricl S (1995) Rheology of industrial polysaccharides Theory and applications. Blackie Academic and Professional, London
Aklonis JJ, Mac Knight WJ (1983) Introduction to polymer viscoelasticity. Wiley, New York
Ward IM, Hadley PW (1993) An introduction to the mechanical properties of solid polymers. Wiley, New York
Sperling LH ( 1986) Introduction to physical polymer science. Wiley, New York
De Smedt SC, Dekeyser P, Ribitsch V, Lauwers A, Demeester (1993) Viscoelastic and transient network properties of hyaluronic acid as a function of the concentration. Biorheology 30:631
Flory PJ (1953) Principles of Polymer Chemistry. Cornell University Press, New York
Schurz J (1991) Rheology of polymer solutions of the network type. Prog Polym Sci 16:1–53
Flory PJ, Rehner BD. (1943). Statistical mechanics of cross-linked polymer networks. J Chem Phys 11:521–526
Peppas NA, Merrill EW (1976). PVA hydrogels: reinforcement of radiation-crosslinked networks by crystallization. J Polym Sci Polym Chem 14:441–457
Ricka J, Tanaka T (1984) Swelling of ionic gels: quantitative performance of the Donnan theory. Macromolecules 17:2916–2921
Tanaka T (1979) Phase transition in gels and a single polymer. Polymer 20:1404–1412
Brannon-Peppas L, Peppas NA (1990) The equilibrium swelling behavior of porous and non-porous hydrogels. In: Brannon-Peppas L, Harland RS (ed) Absorbent polymer technology. Elsevier, Amsterdam
Canal T, Peppas NA (1989) Correlation between mesh size and equilibrium degree of swelling of polymeric networks. J Biomed. Mater Res 23:1183–1193
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 2009 Springer-Verlag Italia, Milan
About this chapter
Cite this chapter
Borzacchiello, A., Ambrosio, L. (2009). Structure-Property Relationships in Hydrogels. In: Hydrogels. Springer, Milano. https://doi.org/10.1007/978-88-470-1104-5_2
Download citation
DOI: https://doi.org/10.1007/978-88-470-1104-5_2
Publisher Name: Springer, Milano
Print ISBN: 978-88-470-1103-8
Online ISBN: 978-88-470-1104-5
eBook Packages: Chemistry and Materials ScienceChemistry and Material Science (R0)