Abstract
Multifocal tumors are not multiple tumors; they originate from a unique cellular clone and grow multifocally in a single organ (liver, kidney, thyroid, etc.). These tumors are not included as multiple primary malignancies (MPM), but they can represent a single event of this syndrome. Multicentric tumors are also different because they develop simultaneously in more than one organ (e.g, breast, mono- or bilaterally in the kidney), but without a clonal relationship with respect to their carcinogenesis. The differential diagnosis is often very difficult. Examples of multifocality are mammary carcinoma, renal cell carcinoma, hepatocellular carcinoma, and esophageal adenocarcinoma.
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© 2009 Springer-Verlag Italia
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de Werra, C., Donzelli, I., Perone, M., Micco, R.D., Orabona, G. (2009). Multifocal and Multicentric Tumors. In: Multiple Primary Malignancies. Updates in Surgery. Springer, Milano. https://doi.org/10.1007/978-88-470-1095-6_9
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DOI: https://doi.org/10.1007/978-88-470-1095-6_9
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