Abstract
Thymic hyperplasia describes a nonneoplastic condition of the thymus, characterized by an increased number of the constituent cells of the organ. This concept was initially introduced by Castleman in the late 1940s to define the thymic changes seen in association with myasthenia gravis [1]. Years later, Rosai and Levine [2] in the A.F.I.P. fascicle on “Tumors of the thymus” identified two distinct types of thymic hyperplasia on the basis of histopathologic criteria: true thymic hyperplasia, defined by an increase in the size and weight of the organ that retains a normal microscopic morphology, and lymphoid (or follicular) hyperplasia, characterized by the presence of lymphoid follicles with active germinal centers in the thymic medulla. In the last case, the size and weight of the thymus can be increased, but in most instances they are within normal limits. The term thymitis (or autoimmune thymitis), originally coined by Goldstein in 1966 [3], has been used interchangeably by some authors to denote the lymphoid hyperplasia of the thymus, since its morphological features, both at the light and electron microscopic levels, are markedly similar to those observed in any chronic inflammatory process of other organs [4, 5], being characterized by the presence of peripheral B lymphocytes, lymphoid follicles, and diffuse plasmacytosis.
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References
Castleman B (1955) Atlas of tumor pathology. Tumors of the thymus gland, fascicle 19. Armed Forces Institute of Pathology, Washington, DC
Rosai J, Levine GD (1976) Atlas of tumor pathology. Tumors of the thymus, Second series, fascicle 13. Armed Forces Institute of Pathology, Washington, DC
Goldstein G (1966) Thymitis and myasthenia gravis. Lancet 2:1164–1167
Sloan HE (1943) The thymus in myasthenia gravis with observations in normal anatomy and histology of the thymus. Surgery 13:154–174
Simpson JA (1958) An evaluation of thymectomy in myasthenia gravis. Brain 81:112–144
Young M, Turnbull HM (1931) An analysis of the data collected by the status lymphaticus investigation committee. J Pathol Bacteriol 34:213–258
Steinmann GG, Müller-Hermelink HK (1984) Lymphocyte differentiation and its microenvironment in the human thymus during aging. Monogr Dev Biol 17:142–155
Kendall MD, Johnson HR, Singh J (1980) The weight of the human thymus gland at necroscopy. J Anat 131:483–497
Judd RL, Welch SL (1988) Myoid cell differentiation in true thymic hyperplasia and lymphoid hyperplasia. Arch Pathol Lab Med 112:1140–1144
Linegar AG, Odell JA, Fennell WM et al (1993) Massive thymic hyperplasia. Ann Thorac Surg 55:1197–1201
Arliss J, Scholes J, Dickson PR et al (1988) Massive thymic hyperplasia in an adolescent. Ann Thorac Surg 45:220–222
Wenger MC, Cohen AJ, Greensite F (1994) Thymic rebound in a patient with scrotal mesothelioma. J Thorac Imaging 9:145–147
Ricci C, Pescarmona E, Rendina EA et al (1989) True thymic hyperplasia: A clinicopathological study. Ann Thorac Surg 47:741–745
Lamesch AJ (1983) Massive thymic hyperplasia in infants. Z Kinderchir 38:16–18
Tatebe S, Oka K, Uehara A et al (2006) Unusual remnant thymic tissue in an adult mimicking malignant neoplasm: Escape from age-related involution. Thorac Cardiovasc Surg 54:138–140
Yoshitake T, Itoyama S, Masunaga A et al (1994) Focal thymic hyperplasia in an adult: Report of a case. Surg Today 24:72–74
Katz SM, Chatten J, Bishop HC et al (1977) Report of a case of gross thymic hyperplasia in a child. Am J Clin Pathol 68:786–790
Pompeo E, Cristino B, Mauriello A et al (1999) Recurrent massive hyperplasia of the thymus. Scand Cardiovasc J 33:306–308
Ruco LP, Rosati S, Palmieri B et al (1989) True thymic hyperplasia: A histological and immunohistochemical study. Histopathology 15:640–643
Miniero R, Busca A, Leonardo E et al (1993) Rebound thymic hyperplasia following high dose chemotherapy and allogeneic BMT. Bone Marrow Transplant 11:67–70
Marchevsky AM, Kaneko M (1992) Surgical pathology of the mediastinum, 2 edn. Raven Press, New York
Sauter ER, Arensman RM, Falterman KW (1991) Thymic enlargement in children. Am Surg 57:21–23
Filler RM, Simpson JS, Ein SH (1979) Mediastinal masses in infants and children. Pediatr Clin North Am 26:677–690
Pedroza Meléndez A, Larenas-Linnemann D (1997) Thymus hyperplasia, differential diagnosis in the wheezing infant. Allergol Immunopathol (Madr) 25:59–62
O’Shea PA, Pansatiankul B, Farnes F (1978) Giant thymic hyperplasia in infants: Immunologic, histologic, and ultrastructural observations. Lab Invest 38:391
Rüther U, Müller HA, Nunnensiek C et al (1990) Thymus hyperplasia in patients with malignant testicular tumors. Med Klin (Münich) 85:72–77
Pagliai F, Rigacci L, Briganti V et al (2003) PET scan evaluation of thymic mass after autologous peripheral blood stem-cell transplantation in an adult with non-Hodgkin’s lymphoma. Leuk Lymphoma 44:2015–2018
Hessissen L, Nachef MN, Kili A et al (2006) Thymic hyperplasia following treatment for nephroblastoma. Arch Pediatr 13:358–360
Peylan-Ramu N, Haddy TB, Jones E et al (1989) High frequency of benign mediastinal uptake of gallium-67 after completion of chemotherapy in children with highgrade non-Hodgkin’s lymphoma. J Clin Oncol 7:1800–1806
Hermann R, Greminger P, Dommann-Scherrer C et al (1994) Diffuse thymus hyperplasia following chemotherapy for nodular sclerosing Hodgkin lymphoma. Schweiz Med Wochenschr 124:1666–1671
Ford EG, Lockhart SK, Sullivan MP et al (1987) Mediastinal mass following chemotherapeutic treatment of Hodgkin’s disease: Recurrent tumor or thymic hyperplasia? J Pediatr Surg 22:1155–1159
Caffey J, de Liberti C (1959) Acute atrophy of the thymus induced by adrenocorticosteroids. AJR Am J Roentgenol 82:530–540
Riazmontazer N, Bedayat G (1993) Aspiration cytology of an enlarged thymus presenting as a mediastinal mass. A case report. Acta Cytol 37:427–430
Hoerl HD, Wojtowycz M, Gallagher HA et al (2000) Cytologic diagnosis of true thymic hyperplasia by combined radiologic imaging and aspiration cytology: A case report including flow cytometric analysis. Diagn Cytopathol 23:417–421
Bangerter M, Behnisch W, Griesshammer M (2000) Mediastinal masses diagnosed as thymus hyperplasia by fine needle aspiration cytology. Acta Cytol 44:743–747
Gerhardt S, Gehling G, Schuster P (2004) Rebound hyperplasia of the thymus with secondary intrathymic bleeding. Rare differential diagnosis of acute chest pain. Dtsch Med Wochenschr 129:1916–1918
Langer CJ, Keller SM, Erner SM (1992) Thymic hyperplasia with hemorrhage simulating recurrent Hodgkin disease after chemotherapy-induced complete remission. Cancer 70:2082–2086
Eifinger F, Ernestus K, Benz-Bohm G et al (2007) True thymic hyperplasia associated with severe thymic cyst bleeding in a newborn: Case report and review of the literature. Ann Diagn Pathol 11:358–362
Tangthangtham A, Chonmaitri I, Subhannachart P et al (1998) Solitary fibrous tumor arising from hyperplastic thymus. J Med Assoc Thai 81:708–711
Gelfand DW, Goldman AS, Law EJ et al (1972) Thymic hyperplasia in children recovering from thermal burns. J Trauma 12:813–817
Rizk G, Cueto L, Amplatz K et al (1972) Rebound enlargement of the thymus after successful corrective surgery for transposition of the great vessels. Am J Roentgenol Radium Ther Nucl Med 116:528–530
Balcom RJ, Hakanson DO, Werner A et al (1985) Massive thymic hyperplasia in an infant with Beckwith-Wiedemann syndrome. Arch Pathol Lab Med 109:153–155
Schilke K, Schaefer F, Waldherr R et al (2000) A case of Perlman syndrome: Fetal gigantism, renal dysplasia, and severe neurological deficits. Am J Med Genet 91:29–33
Itoh H, Chuganji Y, Kodama Y et al (2000) Pena-shokeir type I syndrome with thymic and systemic lymphoid hyperplasia: Report of an autopsy case. Hum Pathol 31:1321–1324
Elias S, Boelen L, Simpson JL (1978) Syndromes of camptodactyly, multiple ankylosis, facial anomalies, and pulmonary hypoplasia. Birth Defects Orig Artic Ser 14:243–251
Cohen M, Hill CA, Cangir A et al (1980) Thymic rebound after treatment of childhood tumors. AJR Am J Roentgenol 135:151–156
Young GA, Grace J, Williams BG et al (1991) An unusual cutaneous lymphoma with B and T cell characteristics showing gallium-67 positive benign thymic hyperplasia following intensive chemotherapy. Aust N Z J Med 21:447–450
Scheinpflug K, Schmitt J, Jentsch-Ullrich K et al (2003) Thymic hyperplasia following successful treatment for nodular-sclerosing Hodgkin’s disease. Leuk Lymphoma 44:1615–1617
Akaki S, Shinya T, Sato S et al (2006) Positive gallium-67 and thallium-201 scans in thymic rebound after chemotherapy for lymphoma. Ann Nucl Med 20:161–163
Leibundgut K, Willi U, Plüss HJ (1992) Thymic rebound following successful chemotherapy of B-lymphoma in an adolescent boy. Eur J Pediatr 151:95–97
Düe W, Dieckmann KP, Stein H (1989) Thymic hyperplasia following chemotherapy of a testicular germ cell tumor. Immunohistological evidence for a simple rebound phenomenon. Cancer 63:446–449
Dieckmann KP, Düe W, Bauknecht KJ et al (1988) Reactive benign thymus hyperplasia following cytostatic chemotherapy. Dtsch Med Wochenschr 113:598–601
Moul JW, Fernandez EB, Bryan MG et al (1994) Thymic hyperplasia in newly diagnosed testicular germ cell tumors. J Urol 152:1480–1483
Hansen LJ, Madsen EL, Moller MN (1993) Benign enlargement of the thymus after chemotherapy of metastasizing testicular cancer. Ugeskr Laeger 155:1141–1142
Chertoff J, Barth RA, Dickerman JD et al (1991) Rebound thymic hyperplasia five years after chemotherapy for Wilms’ tumor. Pediatr Radiol 21:596–597
Bell BA, Esseltine DW, Azouz EM (1984) Rebound thymic hyperplasia in a child with cancer. Med Pediatric Oncol 12:144–147
Panadero MA, Cruz JJ, Gomez A et al (1996) Mediastinal mass following chemotherapy in patient with Ewing sarcoma and osteosarcoma. J Intern Med 239:457–460
Sehbai AS, Tallaksen RJ, Bennett J et al (2006) Thymic hyperplasia after adjuvant chemotherapy in breast cancer. J Thorac Imaging 21:43–46
Hara M, McAdams HP, Vredenburgh JJ et al (1999) Thymic hyperplasia after high-dose chemotherapy and autologous stem cell transplantation: Incidence and significance in patients with breast cancer. AJR Am J Roentgenol 173:1341–1344
Simmonds P, Silberstein M, McKendrick J (1993) Thymic hyperplasia in adults following chemotherapy for malignancy. Aust N Z J Med 23:264–267
Suzuki K, Kurokawa K, Suzuki T et al (1997) Anterior mediastinal metastasis of testicular germ cell tumor: Relation to benign thymic hyperplasia. Eur Urol 32:371–374
Tobisu K, Kakizoe T, Takai K et al (1987) Thymic enlargement following treatment for a metastatic germ cell tumor: A case report. J Urol 137:520–521
Rossi D, Franceschetti S, Capello D et al (2007) Simultaneous diagnosis of CD3+ T-cell large granular lymphocyte leukaemia and true thymic hyperplasia. Leuk Res 31:1019–1021
Choyke PL, Zeman RK, Gootemberg JE et al (1987) Thymic atrophy and regrowth in response to chemotherapy: CT Evaluation. AJR Am J Roentgenol 149:269–272
Shin MS, Ho KJ (1983) Diffuse thymic hyperplasia following chemotherapy for nodular sclerosing Hodgkin’s disease. An immunologic rebound phenomenon? Cancer 51:30–33
Anchisi S, Abele R, Guetty-Alberto M et al (1998) Management of an isolated thymic mass after primary therapy for lymphoma. Ann Oncol 9:95–100
Michel F, Gilbeau JP, Six C et al (1995) Progressive mediastinal widening after therapy for Hodgkin’s disease. Acta Clin Belg 50:282–287
Pendlebury SC, Boyages S, Koutts J et al (1992) Thymic hyperplasia associated with Hodgkin disease and thyrotoxicosis. Cancer 70:1985–1987
Edington H, Salwitz J, Longo DL et al (1986) Thymic hyperplasia masquerading as recurrent Hodgkin’ s disease: Case report and review of the literature. J Surg Oncol 33:120–123
Carmosino L, DiBenedetto A, Feffer S (1985) Thymic hyperplasia following successful chemotherapy. A report of two cases and review of the literature. Cancer 56:1526–1528
Hendriks JM, Van Schil PE, Schrijvers D et al (1999) Rebound thymic hyperplasia after chemotherapy in a patient treated for pulmonary metastases. Acta Chir Belg 99:312–314
Sperandio P, Tomio P, Oliver RT et al (1996) Gonadal atrophy as a cause of thymic hyperplasia after chemotherapy. Br J Cancer 74:991–992
Kissin CM, Husband JE, Nicholas D et al (1987) Benign thymic enlargement in adults after chemotherapy: CT demonstration. Radiology 163:67–70
White SR, Hall JB, Little A (1986) An approach to mediastinal masses associated with hyperthyroidism. Chest 90:691–693
Nakamura T, Murakami M, Horiguchi H et al (2004) A case of thymic enlargement in hyperthyroidism in a young woman. Thyroid 14:307–310
Budavari AI, Whitaker MD, Helmers RA (2002) Thymic hyperplasia presenting as anterior mediastinal mass in two patients with Graves diseases. Mayo Clin Proc 77:495–499
Murakami M, Hosoi Y, Negisci T et al (1996) Thymic hyperplasia in patient with Graves’ disease. Identification of thyrotropin receptors in human thymus. J Clin Invest 98:2228–2234
Wortsman J, McConnachie P, Baker JR Jr et al (1988) Immunoglobulins that cause thymocyte proliferation from a patient with Graves’ disease and an enlarged thymus. Am J Med 85:117–121
Scheiff JM, Cordier AC, Haumont S (1977) Epithelial cell proliferation in thymic hyperplasia induced by triiodothyronine. Clin Exp Immunol 27:516–521
Ribeiro-Carvalho MM, Farias-de-Oliveira DA, Villaverde DM et al (2002) Triiodothyronine modulates extracellular matrix-mediated interactions between thymocytes and thymic microenvironmental cells. Neuroimmunomodulation 10:142–152
Ribeiro-Carvalho MM, Lima-Quaresma KR, Mouço T et al (2007) Triiodothyronine modulates thymocyte migration. Scand J Immunol 66:17–25
Yulish BS, Owens RP (1980) Thymic enlargement in a child during therapy for primary hypothyrodism. AJR Am J Roentgenol 135:157–158
Niendorf ER, Parker JA, Yechoor V et al (2005) Thymic hyperplasia in thyroid cancer patients. J Thorac Imaging 20:1–4
Michigisci T, Mizukami Y, Shuke N et al (1993) Visualization of the thymus with therapeutic doses of radioiodine in patients with thyroid cancer. Eur J Nucl Med 20:75–9
Montella L, Caraglia M, Abbruzzese A et al (2005) Mediastinal images resembling thymus following 131-I treatment for thyroid cancer. Monaldi Arch Chest Dis 63:114–117
Bazzoni N, Ambrosi B, Arosio M et al (1990) Acromegaly and thymic hyperplasia: A case report. J Endocrinol Invest 13:931–915
Polgreen L, Steiner M, Dietz CA et al (2007) Thymic hyperplasia in a child treated with growth hormone. Growth Horm IGF Res 17:41–46
Savino W, Postel-Vinay MC, Smaniotto S et al (2002) The thymus gland: A target organ for growth hormone. Scan J Immunol 55:442–452
de Mello-Coelho V, Gagnerault MC, Souberbielle JC et al (1998) Growth hormone and its receptor are expressed in human thymic cells. Endocrinology 139:3837–3842
Smaniotto S, de Mello-Coelho, Villa-Verde DM et al (2005) Growth hormone modulates thymocyte development in vivo through a combined action of laminin and CXC chemokine ligand 12. Endocrinology 146:3005–3017
Timsit J, Savino W, Safieh B et al (1992) Growth hormone and insulin-like growth factor-I stimulate hormonal function and proliferation of thymic epithelial cells. J Clin Endocrinol Metab 75:183–188
Fahy GM (2003) Apparent induction of partial thymic regeneration in a normal human subject: A case report. J Anti Aging Med 6:219–227
Caffey J, Sibley R (1960) Regrowth and overgrowth of the thymus after atrophy induced by oral administration of adrenocorticosteroids in human infants. Pediatrics 26:762–770
Doppman JL, Oldfield EH, Chrousos GP et al (1986) Rebound thymic hyperplasia after treatment of Cushing’ s syndrome. AJR Am J Roentgenol 147:1145–1147
Tabarin A, Catargi B, Chanson P et al (1995) Pseudotumors of the thymus after correction of hypercortisolism in patients with ectopic ACTH syndrome: A report of five cases. Clin Endocrinol (Oxf) 42:207–213
Otha K, Shichiri M, Kameya T et al (2000) Thymic hyperplasia as source of ectopic ACTH production. Endocr J 47:487–492
Sloper JC (1955) The pathology of the adrenals, thymus and certain other endocrine glands in Addison’ s disease: An analysis of 37 necropsies. Proc R Soc Med 48:625–628
Ferri C, Colaci M, Battolla L et al (2006) Thymus alterations and systemic sclerosis. Rheumatology (Oxford) 45:72–75
Pardo-Mindan FJ, Crisci CD, Serrano M et al (1980) Immunological aspects of sarcoidosis associated with true thymic hyperplasia. Allergol Immunopathol (Madrid) 8:91–96
Nomori H, Ishihara T, Torikata C et al (1990) A case of massive true thymic hyperplasia with non-Hodgkin’ s lymphoma. Chest 98:1304–1305
Lee Y, Moallem S, Clauss RH (1979) Massive hyperplastic thymus in a 22-month-od infant. Ann Thorac Surg 27:356–358
Judd RL (1987) Massive thymic hyperplasia with myoid cell differentiation. Hum Pathol 18:1180–1183
Nezelof C, Normand C (1986) Tumor-like massive thymic hyperplasia in childhood: A possible defect of T-cell maturation, histological and cytoenzymatic studies of three cases. Thymus 8:177–186
Hofmann WJ, Momburg F, Möller P et al (1988) Intra-and extrathymic B cells in physiologic and pathologic conditions. Immunohistochemical study on normal thymus and lymphofollicular hyperplasia of the thymus. Virchows Arch A Pathol Anat Histopathol 412:431–442
Henry K (1968) The thymus in rheumatic heart disease. Clin Exp Immunol 3:509–523
Middleton G (1967) The incidence of follicular structures in the human thymus at autopsy. Aust J Exp Biol Med Sci 45:189–199
Judd R, Bueso-Ramos C (1990) Combined true thymic hyperplasia and lymphoid hyperplasia in Graves’ disease. Pediatr Pathol 10:829–836
Moran CA, Suster S, Gil J et al (1990) Morphometric analysis of germinal centres in nonthymomatous patients with myasthenia gravis. Arch Pathol Lab Med 114:689–691
Murai H, Hara H, Hatae T et al (1997) Expression of CD23 in the germinal center of thymus from myasthenia gravis patients. J Neuroimmunol 76:61–69
Palestro G, Tridente G, Botto Micca F et al (1983) Immunohistochemical and enzyme histochemical contributions to the problem concerning the role of the thymus in the pathogenesis of myasthenia gravis. Virchows Arch B Cell Pathol Incl Mol Pathol 44:173–186
Tamaoki N, Habu S, Kameya T (1971) Thymic lymphoid follicles in autoimmune diseases. II. Histological, histochemical and electron microscopic studies. Keio J Med 20:57–68
Bofill M, Janossy G, Willcox N et al (1985) Microenvironments in the normal thymus and the thymus in myasthenia gravis. Am J Pathol 119:462–473
Phillips LH, Torner JC (1996) Epidemiologic evidence for a changing natural history of myasthenia gravis. Neurology 47:1233–1238
Matsuda M, Dohi-Iijima N, Nakamura A et al (2005) Increase in incidence of elderly-onset patients with myasthenia gravis in Nagano Prefecture Japan. Intern Med 44:572–577
Wekerle H, Müller-Hermelink HK (1986) The thymus in myasthenia gravis. In Müller-Hermelink HK (ed) The human thymus. Springer-Verlag, Berlin, pp 179–206
Marx A, Wilisch A, Schultz A et al (1997) Pathogenesis of myasthenia gravis. Virchows Arch 430:355–364
Joshi VV, Oleske JM, Minnefor AB et al (1984) Pathology of suspected acquired immune deficiency syndrome in children: A study of eight cases. Pediatr Pathol 2:71–87
Nagane Y, Utsugisawa K, Obara D et al (2003) Dendritic cells in hyperplastic thymuses from patients with myasthenia gravis. Muscle Nerve 27:582–589
Emilie D, Crevon MC, Cohen-Kaminsky S et al (1991) In situ production of interleukins in hyperplastic thymus from myasthenia gravis patients. Hum Pathol 22:461–468
Rosenberg M, Jaúregui WO, Herrera MR et al (1986) Recurrence of thymic hyperplasia after trans-sternal thymectomy in myasthenia gravis. Chest 89:888–889
Schalke BC, Mertens HG, Kirchner T et al (1987) Long-term treatment with azathioprine abolishes thymic lymphoid follicular hyperplasia in myasthenia gravis. Lancet 2(8560):682
Kirchner T, Schalke B, Melms A et al (1986) Immunohistological patterns of non-neoplastic changes in the thymus in Myasthenia gravis. Virchows Arch B Cell Pathol Incl Mol Pathol 52:237–257
Ishii W, Matsuda M, Hanyuda M et al (2007) Comparison of the histological and immunohistochemical features of the thymus in young-and elderly-onset myasthenia gravis without thymoma. J Clin Neurosci 14:110–115
Mackay IR, Degail P (1963) Thymic “germinal centers” and plasma cells in systemic lupus erythematosus. Lancet 2(7309):667
Goldstein G, Abbot A, Mackay IR (1968) An electronmicroscope study of the human thymus: Normal appearances and findings in myasthenia gravis and systemic lupus erithematosus. J Pathol Bacteriol 95:211–215
Biggart JD, Nevin NC (1967) Hyperplasia of the thymus in progressive systemic sclerosis. J Pathol Bacteriol 93:334–337
Burnet FM, Mackay IR (1962) Lymphoepithelial structures and autoimmune diseases. Lancet 2:1030–1033
Morgenstern NL, Shearn MA (1973) Thymic hyperplasia in Behçet’s syndrome. Lancet 1(7801):482
Izumi H, Nobukawa B, Takahashi K et al (2005) Multilocular thymic cyst associated with follicular hyperplasia: Clinicopathologic study of 4 resected cases. Hum Pathol 36:841–844
Aarli JA, Gilhus NE, Matre R (1992) Myasthenia gravis with thymoma is not associated with an increased incidence of non-muscle autoimmune disorders. Autoimmunity 11:159–162
Lindner A, Schalke B, Toyka KV (1997) Outcome in juvenile-onset myasthenia gravis: A retrospective study with long-term follow-up of 79 patients. J Neurol 244:515–520
Pescarmona E, Rendina EA, Ricci C et al (1989) Histiocytosis X and lymphoid follicular hyperplasia of the thymus in myasthenia gravis. Histopathology 14:465–470
Wong KF, Chau KF, Chan JK et al (1995) Pure red cell aplasia associated with thymic lymphoid hyperplasia and secondary erythropoietin resistance. Am J Clin Pathol 103:346–347
Michie W, Gunn A (1966) The thyroid, the thymus and autoimmunity. Br J Clin Pract 20:9–13
Sandler M, Sacks G, Linde R et al (1983) The CT detection of thymic hyperplasia in association with thyrotoxicosis: Case report. Comput Radiol 7:365–368
Beddingfield GW, Campbell DC Jr, Hood RH Jr et al (1967) Simultaneous disorders of thyroid and thymus. Report of two cases. Ann Thorac Surg 4:445–450
Van Herle AJ, Chopra IJ (1971) Thymic hyperplasia in Graves’ disease. J Clin Endocrinol Metab 32:140–146
Nicholson RL (1978) Thymic hyperplasia in thyrotoxicosis. J Can Assoc Radiol 29:264–265
Corridan M (1963) The thymus in hepatic cirrhosis. J Clin Pathol 16:445–447
Tsuchiya M, Asakura H, Yoshimatsu H (1989) Thymic abnormalities and autoimmune disease. Keio J Med 38:383–402
Tsuchiya M, Hibi T, Watanabe M et al (1991) Thymectomy in ulcerative colitis: A report of cases over a 13 year period. Thymus 17:67–73
Seemayer TA, Laroche AC, Russo P et al (1984) Precocious thymic involution manifest by epithelial injury in the acquired immune deficiency syndrome. Hum Pathol 15:469–474
Davis AE Jr (1984) The histopathological changes in the thymus gland in the acquired immune deficiency syndrome. Ann N Y Acad Sci 437:493–502
Grody WW, Fligiel S, Naeim F (1985) Thymus involution in the acquired immunodeficiency syndrome. Am J Clin Pathol 84:85–95
Schuurman HJ, Krone WJ, Broekhuizen R et al (1989) The thymus in acquired immune deficiency syndrome. Comparison with other types of immunodeficiency diseases, and presence of components of human immunodeficiency virus type 1. Am J Pathol 134:1329–1338
Linder J (1987) The thymus gland in secondary immunodeficiency. Arch Pathol Lab Med 111:1118–1122
Haynes BF, Hale LP (1998) The human thymus. A chimeric organ comprised of central and peripheral lymphoid components. Immunol Res 18:175–192
Joshi VV, Oleske JM, Saad S et al (1986) Thymus biopsy in children with acquired immunodeficiency syndrome. Arch Pathol Lab Med 110:837–842
Quijano G, Siminovich M, Drut R (1997) Histopathologic findings in the lymphoid and reticuloendothelial system in pediatric HIV infection: A postmortem study. Pediatr Pathol Lab Med 17: 845–856
Müller JG, Stahl-Hennig C, Rethwilm A et al (1991) Morphological alterations of lymph nodes and thymus during the early course of SIV infection of rhesus monkeys. Verh Dtsch Ges Pathol 75:102–107
Müller JG, Krenn V, Schindler C et al (1993) Alterations of thymus cortical epithelium and interdigitating dendritic cells but no increase of thymocyte cell death in the early course of simian immunodeficiency virus infection. Am J Pathol 143:699–713
Prevot S, Audouin J, Andre-Bougaran J et al (1992) Thymic pseudotumorous enlargement due to follicular hyperplasia in a human immunodeficiency virus sero-positive patient. Immunohistochemical and molecular biological study of viral infected cells. Am J Clin Pathol 97:420–425
Burke AP, Anderson D, Benson W et al (1995) Localization of human immunodeficiency virus 1 RNA in thymic tissues from asymptomatic drug addicts. Arch Pathol Lab Med 119:36–41
Mishalani SH, Lones MA, Said JW (1995) Multilocular thymic cyst. A novel thymic lesion associated with human immunodeficiency virus infection. Arch Pathol Lab Med 119:467–470
Kontny HU, Sleasman JW, Kingma DW et al (1997) Multilocular thymic cysts in children with human immunodeficiency virus infection: Clinical and pathologic aspects. J Pediatr 131:264–270
Avila NA, Mueller BU, Carrasquillo JA et al (1996) Multilocular thymic cysts: Imaging features in children with human immunodeficiency virus infection. Radiology 201:130–134
Kondo K, Miyoshi T, Sakiyama S et al (2001) Multilocular thymic cyst associated with Sjogren’ s syndrome. Ann Thorac Surg 72:1367–1369
Moran CA, Suster S (1997) Mediastinal yolk sac tumors associated with prominent multilocular cystic changes of thymic epithelium: A clinicopathologic and immunohistochemical study of five cases. Mod Pathol 10:800–803
Moran CA, Suster S (1995) Mediastinal seminomas with prominent cystic changes. A clinicopathologic study of 10 cases. Am J Surg Pathol 19:1047–1053
Liang SB, Ohtsuki Y, Sonobe H et al (1996) Multilocular thymic cysts associated with thymoma. A case report. Pathol Res Pract 192:1283–1287
Mroczek EC, Seemayer TA, Grierson HL et al (1987) Thymic lesions in fatal infectious mononucleosis. Clin Immunol Immunopathol 43:243–255
Henry K (1992) The thymus gland. In: Henry K, Symmers WSTC (eds) Thymus, lymph nodes, spleen and lymphatics. Churchill Livingstone, Edinburgh, pp 27–139
Nobrega C, Cardona PJ, Roque S et al (2007) The thymus as a target for mycobacterial infections. Microbes Infect 9:1521–1529
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Maiorana, A., Reggiani-Bonetti, L. (2008). Hyperplastic and Inflammatory Pathology of the Thymus. In: Lavini, C., Moran, C.A., Morandi, U., Schoenhuber, R. (eds) Thymus Gland Pathology. Springer, Milano. https://doi.org/10.1007/978-88-470-0828-1_5
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