Abstract
Positron emission tomography (PET) [1] is a tomographic technique of nuclear medicine in which a computer-generated image of local radioactive tracer distribution in tissues is produced through the detection of annihilation photons emitted when radio-nuclides introduced into the body decay and release positrons. PET with 18F-fluorodeoxyglucose (18F-FDG) uses a radio-labeled analog of glucose to image relative glucose metabolic rates in various tissues. Because glucose metabolism is increased in many malignancies, 18F-FDG PET is a sensitive method for detecting, staging, and monitoring the effects of therapy of many tumors. Computed tomography (CT) is a tomographic imaging technique that uses an X-ray beam to produce anatomic images. This anatomic information is used to detect and help to determine the location and extent of malignancies. Combined PET/CT devices provide both the metabolic information from PET and the anatomic information from CT in a single examination. As shown in some clinical experiences, the information obtained by PET-CT appears to be more accurate in evaluating patients with known or suspected malignancies than does the information obtained from either PET or CT separately and interpreted side by side.
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References
Delbeke D, Coleman RE, Guiberteau MJ et al (2006) Procedure guideline for tumor imaging with 18F-FDG PET/CT. J Nucl Med 47(5):885–895
Ayabe Z, Sakakibara N, Matsuura K (1984) 201T1-chloride imaging of malignant thymus neoplasm. Rinsho Hoshasen 29(2):341–342
Srirajaskanthan R, Toubanakis C, Dusmet M, Caplin ME (2008) A review of thymic tumours. Lung Cancer 60(1):4–13
Kazuya K, Kiyoshi Y, Masaru T et al (2004) Who histologic classification is a prognostic indicator in thymoma. Ann Thorac Surg 77:1183–1188
Sasaki M, Kuwabara Y, Ichiya Y et al (1999) Differential diagnosis of thymic tumors using a combination of 11C-Methionine PET and FDG PET. J Nucl Med 40(10):1595–1601
Ferdinand B, Gupta P, Kramer E (2004) Spectrum of Thymic Uptake at 18F-FDG PET. RadioGraphics 24:1611–1616
Alibazoglu H, Alibazoglu B, Hollinger EF et al (2001) Normal thymic uptake of 2-deoxy-2[F-18]fluoro-D-glucose. Clin Nucl Med 24(8):597–600
Bar-Sever Z, Keidar Z, Ben-Barak A et al (2007) The incremental value of 18F-FDG PET/CT in paediatric malignancies. Eur J Nucl Med Mol Imaging 34(5):630–637
Sung YM, Lee KS, Kim BT et al (2006) 18F-FDG PET/CT of thymic epithelial tumors: Usefulness for distinguishing and staging tumor subgroups. J Nucl Med 47(10):1628
Del Rocío Estrada-Sánchez G, Altamirano-Ley J, Ochoa-Carrillo FJ (2007) Normal variants and frequent pitfalls with (18)FDG PET/CT. Cir 75(6):491–497
Ferdinand B, Gupta P, Kramer EL (2004) Spectrum of thymic uptake at 18F-FDG PET. RadioGraphics 24(6):1611–1616 (review)
Patel PM, Alibazoglu H, Ali A et al (1996) Normal thymic uptake of FDG on PET imaging. Clin Nucl Med (10):772–775
Liu RS, Yeh SH, Huang MH et al (1995) Use of fluorine-18 fluorodeoxyglucose positron emission tomography in the detection of thymoma: A preliminary report. Eur J Nucl Med 22(12):1402–1407
El-Bawab H, Al-Sugair AA, Rafay M et al (2007) Role of flourine-18 fluorodeoxyglucose positron emission tomography in thymic pathology. Eur J Cardiothorac Surg 31(4):731–736
Brink I, Reinhardt MJ, Hoegerle S et al (2001) PET: Increased metabolic activity in the thymus gland studied with 18F-FDG. Age dependency and frequency after chemotherapy. J Nucl Med 42(4):591–595
Bagga S, Bloch EM (2006) Imaging of an invasive malignant thymoma on PET Scan: CT and histopathologic correlation. Clin Nucl Med 31(10):614–616
Bogot NR, Quint LE (2005) Imaging of thymic disorders. Cancer Imaging 5(1):139–149
Smith CS, Schöder H, Yeung HW (2007) Thymic extension in the superior mediastinum in patients with thymic hyperplasia: Potential cause of false-positive findings on 18F-FDG PET/CT. AJR Am J Roentgenol 188(6):1716–1721
Ferdinand B, Gupta P, Kramer EL (2004) Spectrum of thymic uptake at 18F-FDG PET1. RadioGraphics 24:1611–1616
Bar-Sever Z, Keidar Z, Ben-Barak A et al (2007) The incremental value of 18F-FDG PET/CT in paediatric malignancies. Eur J Nucl Med Mol Imaging 34(5):630–637
Sung YM, Lee KS, Kim BT et al (2006) 18F-FDG PET/CT of thymic epithelial tumors: Usefulness for distinguishing and staging tumor subgroups. J Nucl Med 47(10):1628–1634
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© 2008 Springer-Verlag Italia
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Bagni, B., Franceschetto, A., Casolo, A., Cucca, M. (2008). PET Features. In: Lavini, C., Moran, C.A., Morandi, U., Schoenhuber, R. (eds) Thymus Gland Pathology. Springer, Milano. https://doi.org/10.1007/978-88-470-0828-1_10
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DOI: https://doi.org/10.1007/978-88-470-0828-1_10
Publisher Name: Springer, Milano
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