Estratto
Per molti anni gli ostetrici hanno notato la presenza di edema generalizzato dei tessuti molli in neonati che più frequentemente andavano incontro a morte [1]. John William Ballantyne, un ginecologo inglese, nel 1892 descrisse una triade costituita da edema materno, idrope fetale e placentomegalia, ma solo mezzo secolo dopo (1943) pubblicò un articolo [2] in cui veniva riconosciuto un gruppo di feti caratterizzato da uno stato anasarcatico (Fig. 19.1) in assenza di malattia emolitica del neonato: fu così descritta e codificata per la prima volta l’idrope fetale non immunologica (NIHF), definita in questo modo proprio per sottolineare l’assenza, in questa patologia, di anticorpi circolanti materni contro antigeni eritrocitari fetali.
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Pietrolucci, M.E., Brienza, L., Arduini, D. (2008). Idrope fetale non immunologica. In: Medicina dell’età prenatale. Springer, Milano. https://doi.org/10.1007/978-88-470-0688-1_19
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