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Hand Transplantation in Monkeys: Technical Details and Immunological Aspects

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Hand Transplantation

Abstract

In the late 1980s, increased interest could be perceived in reconstruction of acquired or congenital deformities with allogeneic composite tissue. This revival was attributed to the introduction of new immunosuppressive drugs in combination with the widespread possibilities of microsurgical reconstruction. As a consequence, composite tissue transplantation studies were performed not only on rodents and dogs but also on monkeys as preparation for future hand transplantation in humans. As far as the literature is concerned, three groups in the world were active at that time on this particular subject. The group of R.K. Daniel in Montreal, Canada and the group of G. Stark in Pittsburgh, Pennsylvania, USA, published in 1986 and 1987, respectively. Both groups worked on baboon [1, 2]. Furthermore, our group in Rotterdam, The Netherlands, worked on rhesus monkeys and published in 1991 and 1992 [3, 4].

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References

  1. Daniel RK, Egerszegi EP, Samulack DD (1986) Tissue transplants in primates for upper extremity reconstruction: a preliminary report. J Hand Surg [Am]11: 1–8

    CAS  Google Scholar 

  2. Stark GB, Swartz WM, Narayanan K, Moller AR (1987) Hand transplantation in baboons. Transplant Proc 19:968–971

    Google Scholar 

  3. Hovius SE, Stevens HP, Van Nierop PW (1992) Allogeneic transplantation of the radial side of the hand in the rhesus monkey: I. Plastic and reconstructive surgery. Plast Reconstr Surg 89:700–709

    Article  PubMed  CAS  Google Scholar 

  4. Hovius SE, Stevens HP, Van Nierop PW (1991) Allogeneic transplantation of the radial side of the hand in the rhesus monkey: I. Thesis (Phd), Erasmus Medical Centre, Rotterdam

    Google Scholar 

  5. Topwik E, Kupiec-Weglinski JW, Schneider TM (1985) Cyclosporine and experimental skin allografts. II. Indefinite survival and development of specific immunologic unresponsiveness. Transplantation 40:714–178

    Article  Google Scholar 

  6. Topwik E, Kupiec-Weglinski JW, Tyler DS (1986) Cyclosporine and experimental skin allografts: long-term survival in rats treated with low maintenance doses: Plast Reconstr Surg 77:268–276

    Article  Google Scholar 

  7. Achauer BM, Hewitt CW, Black KS et al (1986) Long-term skin allograft survival after short-term cyclosporin treatment in a patient with massive burns. Lancet 1:14–15

    Article  PubMed  CAS  Google Scholar 

  8. Frame JD, Sanders R, Goodacre TE, Morgan BD (1989) The fate of meshed allograft skin in burned patients using cyclosporine immunosuppression. Br J Plast Surg 42:27–34

    PubMed  CAS  Google Scholar 

  9. Mackinnon SE, Midha R, Bain J et al (1992) An assessment of regeneration across peripheral nerve allografts in rats receiving short courses of cyclopsporin A immunosuppression. Neuroscience 46:585–593

    Article  PubMed  CAS  Google Scholar 

  10. Fish JS, Bain J, McKee N, Mackinnon SE (1992) The peripheral nerve in the primate immunosuppressed with cyclosporine A: II. Functional evaluation of reinnervated muscle. Plast Reconstr Surg 90:1047–1052

    Article  PubMed  CAS  Google Scholar 

  11. Bain J, Mackinnon SE, Hudson AR (1992) The peripheral nerve in the primate immunosuppressed with cyclosporine A: I. Histologic and electrophysiologic assessment. Plast Reconstr Surg 90:1036–1046

    Article  PubMed  CAS  Google Scholar 

  12. Mackinnon SE, Hudson AR (1992) Clinical application of peripheral nerve transplantation. Plast Reconstr Surg 90:695–699

    Article  PubMed  CAS  Google Scholar 

  13. Tam CM, Yaremchuk MJ, Randolph MA et al (1991) Vascularized muscle allografts and the role of cyclosporine. Plast Reconstr Surg 87:412–418

    Article  Google Scholar 

  14. Guimberteau JC, Baudet J, Panconi B et al (1992) Human allotransplant of a digital flexion system vascularized on the ulnar pedicle: a preliminary report and 1-year follow-up of two cases. Plast Reconstr Surg 89:1135–1147

    Article  PubMed  CAS  Google Scholar 

  15. Paskert JP, Yaremchuk MJ, Randolph MA, Weiland AJ (1987) The role of cyclosporine in prolonging survival in vascularized bone allografts. Plast Reconstr Surg 80:240–247

    Article  PubMed  CAS  Google Scholar 

  16. Siliski JM, Simpkin S, Green CJ (1984) Vascularized whole knee joint allografts in rabbits immunosuppressed with cyclosporin A. Arch Orthop Trauma Surg 103:26–35

    Article  PubMed  CAS  Google Scholar 

  17. Volkov M (1970) Allotransplantation of joints. J Bone Joint Surg Br 52:49–53

    PubMed  CAS  Google Scholar 

  18. Lee WP, Yaremchuk MJ, Pan YC (1991) Relative antigenicity of components of a vascularized limb allograft. Plast Reconstr Surg 87:401–411

    Article  PubMed  CAS  Google Scholar 

  19. Murray JE (1971) Organ transplantation (skin, kidney, heart) and the plastic surgeon. Plast Reconstr Surg 47:425–431

    Article  PubMed  CAS  Google Scholar 

  20. Schwind JV (1962) Homotransplantation of extremities of rats. Radiology 78:806–810

    PubMed  CAS  Google Scholar 

  21. Lapchinsky AG (1960) Recent results of experimental transplantation of preserved limbs and kidneys and possible use of this technique in clinical practice. Ann N Y Acad Sci 87:539–571

    Article  PubMed  CAS  Google Scholar 

  22. Tilney N, Strom TB (1986) Chemical suppression of the immune responses. In: Morris PJ, Tilney NL (eds) Progress in transplantation. Churchill Livingstone, London, pp 1–33

    Google Scholar 

  23. Goldwyn RM, Beach PM, Feldmann D, Wilson RE (1966) Canine limb homotransplantations. Plast Reconstr Surg 37:184–195

    Article  PubMed  CAS  Google Scholar 

  24. Doi K (1979) Homotransplantatoin of limbs in rats. A preliminary report on an experimental study with nonspecific immunosuppressive drugs. Plast Reconstr Surg 64:613–621

    Article  PubMed  CAS  Google Scholar 

  25. Lance EM, Inglis AE, Figarola F, Veith FJ (1971) Transplantation of the canine hind limb. Surgical technique and methods of immunosuppression for allotransplantation. A preliminary report. J Bone Joint Surg Am 53:1137–1149

    PubMed  CAS  Google Scholar 

  26. Black KS, Hewitt CW, Fraser LA et al (1982) Cosmas and Damian in the laboratory. N Engl J Med 306:368–369

    Article  PubMed  CAS  Google Scholar 

  27. Furnas DW, Black KS, Hewitt CW (1983) Indefinite composite tissue (limb) allograft survival in rats with cyclosporine: Possible future implications in plastic and reconstructive surgery. Transplant Proc 15:3063

    CAS  Google Scholar 

  28. Hewitt CW, Black KS, Fraser LA (1983) Cyclosporine A (CyA) is superior to donor-specific blood (DSB) transfusion for the extensive prolongation of rat limb allograft survival. Transplant Proc 15:514–517

    CAS  Google Scholar 

  29. Fritz WD, Swartz WM, Rose S et al (1984) Limb allografts in rats immunosuppressed with cyclosporin A. Ann Surg 199:211–215

    Article  PubMed  CAS  Google Scholar 

  30. Hovius SER, van Adrichem LN, van der Heijden PM (1988) Postoperative monitoring of allogeneic limb transplantation in rats. Ann Plast Surg 21:559–565

    Article  PubMed  CAS  Google Scholar 

  31. Hovius SER, Stevens HP, Van Nierop PW et al (1992) Replantation of the radial side of the hand in the rhesus monkey: anatomical and functional aspects. A preliminary study to composite tissue allografting. J Hand Surg [Br] 17:651–656

    CAS  Google Scholar 

  32. Stevens HP, van der Kwast TH, Timmermanns A et al (1991) Monoclonal antibodies for immunohistochemical labelling of immunocompetent cells in frozen section of rhesus monkey tissues. J Med Primatol 20:386–393

    PubMed  CAS  Google Scholar 

  33. Stevens HP, Roche N, Hovius SER, Jonker M (1990) In vivo immunosuppressive effects of monoclonal antibodies specific for CD3+, CD4+, CD8+, and MHC class II positive cells. Transplant Proc 22:1783–1784

    PubMed  CAS  Google Scholar 

  34. [No Authors listed] (1986) Proceedings of an international symposium on monoclonal antibody therapy with orthoclone OKT3 in renal transplantation. Transplant Proc 18:923–956

    Google Scholar 

  35. Steven HP, Hovius SER, Vuzevski VD et al (1990) Immunological aspects of allogeneic partial hand transplantation in the rhesus monkey. Transplant Proc 22(4):2006–2008

    Google Scholar 

  36. Stevens HP, Hovius SER, Heeney JL et al (1991) Immunologic aspects and complications of composite tissue allografting for upper extremity reconstruction: a study in the rhesus monkey. Transplant Proc 23:623–625

    PubMed  CAS  Google Scholar 

  37. Stevens HP, Holterman L, Haaksma AG et al (1992) Lymphoproliferative disorders developing after transplantation and their relation to simian T-cell leukemia virus infection. Transpl Int 5[Suppl. 1]:450–453

    Google Scholar 

  38. Hovius SER, Stevens HP, Peters B, Van Nierop PW (1991) A protective thermoplast splint for the forearm and hand in nonhuman primates. Lab Anim 25:1–3

    PubMed  CAS  Google Scholar 

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Hovius, S.E.R., Zuijdendorp, H.M., Stevens, J.J.P.D. (2007). Hand Transplantation in Monkeys: Technical Details and Immunological Aspects. In: Lanzetta, M., Dubernard, JM., Petruzzo, P. (eds) Hand Transplantation. Springer, Milano. https://doi.org/10.1007/978-88-470-0374-3_10

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  • DOI: https://doi.org/10.1007/978-88-470-0374-3_10

  • Publisher Name: Springer, Milano

  • Print ISBN: 978-88-470-0373-6

  • Online ISBN: 978-88-470-0374-3

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