Skip to main content

Complicated Malaria and Dengue During Pregnancy

  • Chapter
  • First Online:
  • 1848 Accesses

Abstract

Malarial fever and dengue fever are major global health problems with about half of the world population at risk. Malaria is caused by protozoal parasite of genus Plasmodium by bite of infected female Anopheles mosquito while dengue is caused by dengue virus by bite of infected female Aedes aegypti mosquito. Pregnant patients because of their lowered immunity are at increased risk of developing the severe disease. Complicated malaria and severe dengue lead to adverse maternal and perinatal outcome including mortality. Also there is increased risk of vertical transmission in both. Parenteral artemisinin-based chemotherapy should be started without delay in severe malaria. There is no specific antiviral drug for dengue fever and treatment is mainly supportive and symptomatic. Malaria when timely and adequately treated does not have a residual deficit and the patients recover fully. In dengue fever recovery from infection provides lifelong immunity to that serotype, but subsequent infections by other serotypes increase the risk of developing severe dengue.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   99.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   129.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   129.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  1. Kantele A, Jokiranta S. Review of cases with the emerging fifth human malaria parasite, Plasmodium knowlesi. Clin Infect Dis. 2011;52:1356–62.

    Article  PubMed  Google Scholar 

  2. www.malariasite.com/pregnancy. Kakkillaya, BS. Updated 11 Mar 2015.

  3. Singh N, Shukla MM, Sharma VP. Epidemiology of malaria in pregnancy in central India. Bull World Health Organ. 1999;77(7):567–72.

    CAS  PubMed  PubMed Central  Google Scholar 

  4. Royal College of Obstetricians & Gynecologists. The diagnosis and treatment of malaria in pregnancy. Green-top Guideline No.54b. 2010. p. 7

    Google Scholar 

  5. Poespoprodjo JR, Fobia W, Kenangalem E, Lampah DA, Warikar N, Seal A, et al. Adverse pregnancy outcomes in an area where multidrug-resistant plasmodium vivax and plasmodium falciparum infections are endemic. Clin Infect Dis. 2008;46:1374.

    Article  PubMed  PubMed Central  Google Scholar 

  6. Valecha N, Bhatia S, Mehta S, Biswas S, Dash AP. Congenital malaria with atypical presentation: a case report from low transmission area in India. Malar J. 2007;6:43.

    Article  PubMed  PubMed Central  Google Scholar 

  7. Chilton D, Malik AN, Armstrong M, et al. Use of rapid diagnostic tests for the diagnosis of malaria in UK. J Clin Pathol. 2006;59:862–6.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. World Health Organization. Guidelines for the treatment of Malaria. 2nd ed. Geneva: WHO; 2010.

    Google Scholar 

  9. Jones KL, Donegan S, Lalloo DG. Artesunate versus quinine for treating severe malaria. Cochrane Database Syst Rev. 2007;(4):CD005967.

    Google Scholar 

  10. Dondrop A, Nosten F, Stepneiwska K, Day N, White N. Artesunate versus quinine for treatment of severe falciparum malaria: a randomized trial. Lancet. 2005;366:717–25.

    Article  Google Scholar 

  11. Shukla MM, Singh N, Singh MP, et al. Cerebral malaria in Jabalpur. Indian J Malariol. 1995;32:70–5.

    CAS  PubMed  Google Scholar 

  12. LooareesuwanS PRE, White NJ, Kietinun S, Karbwang J, Rackow C, et al. Quinine and severe falciparum malaria in late pregnancy. Lancet. 1985;2:4–8.

    Article  Google Scholar 

  13. Desai M, ter Kuile FO, Nosten F, McGready R, Asamoa K, Brabin B, Newman RD. Epidemiology and burden of malaria in pregnancy. Lancet Infect Dis. 2007;7:93–104.

    Article  PubMed  Google Scholar 

  14. World Health Organization. Dengue and severe Dengue. Fact sheet No. 17. Geneva: WHO; 2014.

    Google Scholar 

  15. National Vector Borne Disease Control Programme. Dengue/dengue hemorrhagic fever. 2013. http://www.nhp.gov.in/nvdcp.

  16. Machado CR, Machado CS, Rohloff RD, et al. Is pregnancy associated with severe dengue? a review of data from the Rio de Janeiro surveillance information system. PLoS Negl Trop Dis. 2013;7(5):e2217.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Pouliot SH, Xiong X, Harville E, et al. Maternal dengue and pregnancy outcomes: a systematic review. Obstet Gynecol Surv. 2010;65:107–18.

    PubMed  Google Scholar 

  18. Mitra N, Kannan N, Kavita G, Senthil V. Neonatal dengue. Pediatric oncall. [serial online] 2012 [cited 2012 July 1];9. Art #44. Available From: http://www.pediatriconcall.com/Journal/Article/FullText.aspx?artid=494&type=J&tid=&imgid=&reportid=40&tbltype=.

  19. Carles G, Talarmin A, Peneau C, et al. Dengue fever and pregnancy. A study of 38 cases in French Guiana. J Gynecol Obstet Biol Reprod. 2000;29:758–62.

    CAS  Google Scholar 

  20. Fernandez R, Rodriguez T, Borbonet F, et al. Study of the relationship dengue-pregnancy in a group of Cuban mothers. Rev Cubana Med Trop. 1994;46:76–8.

    CAS  PubMed  Google Scholar 

  21. Singh N, Sharma KA, Dadhwal V, Mittal S, Selvi AS. A successful management of dengue fever in pregnancy. Indian J Med Microbiol. 2008;26(4):377–80.

    Article  CAS  PubMed  Google Scholar 

  22. Malhotra N, Chanana C, Kumar S. Dengue infection in pregnancy. Int J Gynaecol Obstet. 2006;94(2):131–2.

    Article  CAS  PubMed  Google Scholar 

  23. Chitra TV, Panicker S. Maternal and fetal outcome of dengue fever in pregnancy. J Vector Borne Dis. 2011;48(4):210–3.

    CAS  PubMed  Google Scholar 

  24. Agrawal P, Garg R, Srivastava S, Verma U, Rani R. Pregnancy outcome in women with Dengue infection in Northern India. Ind J Clin Pract. 2014;24(11):1053–6.

    Google Scholar 

  25. Ostronoff M, Ostronoff F, Florencio R, et al. Serious thrombocytopenia due to dengue hemorrhagic fever treated with high dosages of immunoglobulin. Clin Infect Dis. 2003;36:1623–4.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Haresh U. Doshi MD, PhD .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2016 Springer India

About this chapter

Cite this chapter

Doshi, H.U. (2016). Complicated Malaria and Dengue During Pregnancy. In: Gandhi, A., Malhotra, N., Malhotra, J., Gupta, N., Bora, N. (eds) Principles of Critical Care in Obstetrics. Springer, New Delhi. https://doi.org/10.1007/978-81-322-2686-4_10

Download citation

  • DOI: https://doi.org/10.1007/978-81-322-2686-4_10

  • Published:

  • Publisher Name: Springer, New Delhi

  • Print ISBN: 978-81-322-2684-0

  • Online ISBN: 978-81-322-2686-4

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics