C-Reactive Protein: A Clinical Marker in Cardiovascular Disease

  • Waliza Ansar
  • Shyamasree Ghosh


Atherosclerotic vascular disease reveals the process of inflammation including several key mediators and markers of inflammation as major manifestations of its pathobiology. Different inflammation markers observed in atherosclerotic disease have been implicated for their prediction of risk in vascular disease or vascular events. Among them, extensively studied is C-reactive protein (CRP), a protein categorized under the class of acute-phase response (APR) proteins. CRP has been reported for its most consistent relationship with cardiovascular disease (CVD) and is capable of predicting risk in the future. Recent epidemiological studies in population have confirmed positive associations between CRP and CVD in populations across the globe. The role of CRP in binding with lipoprotein and activation of the complement cascade reactions and its localization in atherosclerotic vessels indicate strongly the involvement of CRP in the pathophysiology of heart diseases. Initially identified for its major role as a marker in acute processes like tissue injury, infection by pathogen, and inflammation, recently it has earned the disease biomarker status in different CVDs. The role of hs-CRP in detection of risk of cardiovascular diseases is highly accomplished. Use of hs-CRP has well-known clinical and pathological significance. Among hundreds of putative cardiovascular risk factors together with factors including behavioral, biochemical, environmental, and genetic risk markers, CRP remains a unique risk predictor globally. The future prospect of C-reactive protein as a disease biomarker in CVD will help add to the knowledge of the pathobiology and to follow-up studies in patients suffering from CVDs.


Cardiovascular diseases (CVDs) C-reactive protein Cardiovascular risk factors Atherosclerosis Inflammation hs-CRP 


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Copyright information

© Springer India 2016

Authors and Affiliations

  • Waliza Ansar
    • 1
  • Shyamasree Ghosh
    • 2
  1. 1.Department of ZoologyBehala CollegeKolkataIndia
  2. 2.National Institute of Science EducationSchool of Biological SciencesBhubaneswarIndia

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