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CRP and Cancer

  • Waliza Ansar
  • Shyamasree Ghosh
Chapter

Abstract

C-reactive protein (CRP) as an acute-phase protein is a marker in inflammation, tissue injury and infection. The role of inflammation and CRP in different cancers is a recent matter of research. Increased CRP level is positively correlated with extent of disease and recurrence in advanced cancer. Its role as an interpreter of survival has been elucidated in melanoma, multiple myeloma, lymphoma, ovarian, renal, pancreatic and gastrointestinal tumors. The testing for CRP levels at the time of diagnosis could help clinicians determine severity of the disease with any adjacent inflammation, the tumor’s state of aggressiveness, or other conditions in the body and help guide therapeutics to improve overall survival. The poor prognosis in patients with different types of solid cancers is correlated with elevated plasma CRP levels. The circulating CRP concentrations has stronger correlation with the severity, extent and progression of many different tumor pathologies and the prognostic significance of these associations are consistent with CRP level. Thus CRP is not just being a marker of disease or an inflammatory biomarker but also it contributes to the pathogenesis of cancer also.

Keywords

Breast cancer Myeloma Lymphoma Sarcoma Carcinoma Metastasis 

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Copyright information

© Springer India 2016

Authors and Affiliations

  • Waliza Ansar
    • 1
  • Shyamasree Ghosh
    • 2
  1. 1.Department of ZoologyBehala CollegeKolkataIndia
  2. 2.National Institute of Science EducationSchool of Biological SciencesBhubaneswarIndia

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