Clinical Management of HPV-Related Oropharyngeal Cancer

  • Marshall R. PosnerEmail author
Part of the Head and Neck Cancer Clinics book series (HNCC)


The demographics and prognosis of locally advanced head and neck squamous cell cancer (HNSCC) have changed dramatically over the past two decades. Epidemiological evidence has revealed a significant increase in the incidence of oropharyngeal cancer (OPC) in North America and Europe [1–3]. Molecular studies of oropharyngeal tumours have revealed that this increase is due to a rise in the incidence of tumours containing human papillomavirus (HPV), most specifically HPV16. Evidence shows that HPV16 is the molecular cause that mechanistically drives the development and viability of the cancer cells [4]. HPV-associated OPC (HPVOPC) presently accounts for ~70 % of OPC seen in the USA, and an increasing fraction of these malignancies is seen in Europe [1, 2, 5].


Overall Survival Radiation Therapy Oncology Group Poor Prognostic Feature Radiation Therapy Oncology Group Study Lower Level Node 
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Copyright information

© Carole Fakhry, Gypsyamber D’Souza, Rehan Kazi and Raghav C. Dwivedi  2015

Authors and Affiliations

  1. 1.Department of OtolaryngologyMount Sinai School of MedicineNew YorkUSA

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