Epidemiology of Oral HPV Infection and HPV-Associated Head and Neck Cancer

  • Kristina R. DahlstromEmail author
  • Erich M. Sturgis
Part of the Head and Neck Cancer Clinics book series (HNCC)


Tobacco and alcohol exposure are the traditional risk factors for malignancies of the head and neck, and account for approximately three-quarters of all cases worldwide and half of the cases in the USA [1]. Infection with human papillomavirus (HPV), particularly type 16, has also been established as yet another important risk factor [2–5]. The overwhelming majority of HPV-associated head and neck cancers (HPV-HNSCCs) arise from the oropharynx [2, 6]. HPV-positive oropharyngeal cancer (OPC) represents a growing aetiologically distinct subset of head and neck cancers, with unique epidemiological, clinical and molecular characteristics that differ from those of HPV-negative cancers.


Standardize Incidence Ratio Tongue Cancer Tonsillar Cancer Tonsillar Squamous Cell Carcinoma 
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Copyright information

© Carole Fakhry, Gypsyamber D’Souza, Rehan Kazi and Raghav C. Dwivedi 2015

Authors and Affiliations

  1. 1.Department of Head and Neck Surgery, MD Anderson Cancer CenterThe University of TexasHoustonUSA

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