Anatomical Sites and Subsites of Head and Neck Cancer

  • Ryan Li
  • Nishant Agrawal
  • Carole FakhryEmail author
Part of the Head and Neck Cancer Clinics book series (HNCC)


Head and neck squamous cell carcinoma (HNSCC) represents the sixth most common solid tumour malignancy with more than 500,000 cases worldwide and 52,000 newly diagnosed cases annually [1]. These tumours arise from the mucosa of the upper aerodigestive tract, which holds important functional roles for respiration, speech and swallowing. Both surgical and non-surgical treatment modalities achieve a cure for ~50 % of HNSCC patients at 5 years; [2] however, these same treatment regimens can also be debilitating, both functionally and cosmetically. An understanding of the anatomical origins of HNSCC tumours is paramount to making an appropriate diagnosis, for treatment and for post-treatment tumour surveillance in all cases.


Oral Cavity Smokeless Tobacco Keratinizing Squamous Cell Carcinoma Oral Cavity Subsite 
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Copyright information

© Carole Fakhry, Gypsyamber D’Souza, Rehan Kazi and Raghav C. Dwivedi  2015

Authors and Affiliations

  1. 1.Department of Otolaryngology – Head and Neck SurgeryThe Johns Hopkins University School of MedicineBaltimoreUSA

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