Pharmaco-Informatics: An Interaction Study of Herbal Compounds with Receptors Implicated in ADHD

  • Preenon Bagchi
  • R. S. Manasa
  • K. S. Shwetha
  • S. C. Harshitha
  • M. Mahesh
  • R. Somashekhar
Conference paper
Part of the Advances in Intelligent Systems and Computing book series (AISC, volume 340)

Abstract

Attention-Deficit/Hyperactivity Disorder (ADHD) is one of the most common neurological disorder seen in children. The 3d structure of the receptor proteins implicated in ADHD used in this work (i.e., ADRA2A, HTR1B, NET1, TPH2, NGF and SNAP25) and modeled by homology modeling. Homology modeling generated five templates for each receptor and the best model was determined by Ramachandran Plot analysis. Again, the best model for each receptor protein are screened with phyto-compounds and best ligand for receptor are ascertained.

Keywords

Attention-deficit/hyperactivity disorder Neurological Developmental Receptor proteins Adolescence Genetics Modeling Docking 

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Copyright information

© Springer India 2015

Authors and Affiliations

  • Preenon Bagchi
    • 1
    • 2
    • 3
  • R. S. Manasa
    • 1
  • K. S. Shwetha
    • 1
  • S. C. Harshitha
    • 1
    • 3
  • M. Mahesh
    • 1
    • 3
  • R. Somashekhar
    • 1
    • 2
    • 3
  1. 1.Azyme Biosciences Pvt. Ltd.BangaloreIndia
  2. 2.Career Point UniversityKotaIndia
  3. 3.Sarvasumana AssociationBangaloreIndia

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