Design of a Mixer for Performing Efficient Mixing to Reduce Overall Assay Response Time

  • Debasis Dhal
  • Piyali Datta
  • Arpan Chakraborty
  • Rajat Kumar Pal
Conference paper
Part of the Advances in Intelligent Systems and Computing book series (AISC, volume 340)


Digital Microfluidic Biochip (DMFB) is revolutionizing many areas of Microelectronics, Biochemistry, and Biomedical sciences. It is also known as ‘Lab-on-a-Chip’ for its popularity as an alternative for laboratory experiments. The mixing of samples and reagents for a biological or chemical lab-on-a-chip is important, yet difficult, in microfluidic operations. As volume is of the order of sub-nanoliter, the mixing of liquids is hindered by laminar flow conditions. The fixed geometric parameters of the mixer and the type of movement of the coalesced droplet control droplet mixing time. In this paper, we study the effects of varying mixer sizes and propose of mixing strategies applicable to some Polymerase Chain Reaction (PCR) where a series of mixing is required. A design of mixer has been proposed including its pin assignment where reduction of time of mixing is a key challenging issue to enhance the performance of the chip in terms of throughput.


Algorithm Cross contamination Lab-on-a-chip Polymerase chain reaction Pin constrained design Reagent Sample Mixer Detection center 


  1. 1.
    Chakrabarty, K., Xu, T.: Digital Microfluidic Biochips Design Automation and Optimization. CRC Press, Boca Raton (2010)CrossRefGoogle Scholar
  2. 2.
    Xu, T., Chakrabarty, K.: Droplet-trace-based array partitioning and a pin assignment algorithm for the automated design of digital microfluidic biochips. IEEE/ACM ICH/SCSS, pp. 112–117 (2006)Google Scholar
  3. 3.
    Fair, R.B.: Digital microfluidics: is a true lab-on-a-chip possible? Microfluid. Nanofluid. 3, 245–281 (2007)CrossRefGoogle Scholar
  4. 4.
    Fair, R.B., Srinivasan, V., Ren, H., Paik, P., Pamula, V., Pollack, M.G.: Electrowetting based on chip sample processing for integrated microfluidics. IEDM, pp. 779–782 (2003)Google Scholar
  5. 5.
    Paik, P., Pamula, V.K., Fair, R.B.: Rapid droplet mixers for digital microfluidic systems. Lab Chip 3, 253–259 (2003)CrossRefGoogle Scholar
  6. 6.
    Paik, P., Pamula, V.K., Pollack, M.G., Fair, R.B.: Electrowetting based droplet mixers for microfluidic systems. Lab Chip 3, 28–33 (2003)CrossRefGoogle Scholar

Copyright information

© Springer India 2015

Authors and Affiliations

  • Debasis Dhal
    • 1
  • Piyali Datta
    • 2
  • Arpan Chakraborty
    • 2
  • Rajat Kumar Pal
    • 2
  1. 1.Department of Information Technology, Triguna Sen School of TechnologyAssam UniversitySilcharIndia
  2. 2.Department of Computer Science and EngineeringUniversity of CalcuttaKolkataIndia

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