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Stem Cell Therapy for Acute and Chronic Liver Failure

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Stem Cell Therapy for Organ Failure

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Abstract

Acute and chronic liver diseases are major causes of morbidity and mortality worldwide. Presently, orthotropic liver transplant is the only gold standard therapy available for such patients suffering from end-stage liver diseases. Availability of suitable liver for transplantation is very low. Thus, each year many patients die waiting for liver transplantation. Considering these facts, there is need of alternative or bridging therapy that will minimize mortality and morbidity of patients who are on transplant waiting list. Thus, stem cell population capable of differentiating to functional hepatocytes could be potential therapy in regenerating damaged liver. Stem cell sources such as embryonic, fetal, induced pluripotent or adult stem cells, or facilitator cells present in bone marrow-derived stem cells can mediate the regenerative process in the liver. This chapter summarizes the use of different sources of stem cells in regenerating damaged liver and an update on recent advances on the management of liver diseases using stem cells.

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Authors and Affiliations

  1. Department of Stem Cells and Regenerative Medicine, D.Y. Patil University, D. Y. Patil Vidyanagar, Kasba Bawda, Kolhapur, 416006, Maharashtra, India

    Meghnad G. Joshi

  2. Stem Plus Biotech Pvt. Ltd., Shiv Meridian, Block #11, MG Road, Opp. Collector Bunglow, Sangli, 416416, MS, India

    Apurva Gadgil

  3. School of Regenerative Medicine, Manipal Institute of Regenerative Medicine, Manipal University, GKVK Post, Bellary Road, Allalasandra, Near Hotel Royal Orchid, Yelahanka, Bangalore, 560065, India

    Ramesh R. Bhonde

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  1. Meghnad G. Joshi
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  2. Apurva Gadgil
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  3. Ramesh R. Bhonde
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Correspondence to Meghnad G. Joshi .

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  1. Department of Stem Cells and Regenerative Medicine, Centre for Interdisciplinary Research, DY Patil University, Kolhapur, Maharashtra, India

    Indumathi Somasundaram

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Joshi, M.G., Gadgil, A., Bhonde, R.R. (2014). Stem Cell Therapy for Acute and Chronic Liver Failure. In: Somasundaram, I. (eds) Stem Cell Therapy for Organ Failure. Springer, New Delhi. https://doi.org/10.1007/978-81-322-2110-4_16

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