Debates in Dacryology: The Mitomycin-C Dilemma

  • Yi-fan Feng


The most common reason for the failure of dacryocystorhinostomy (DCR) surgery is the formation of scar or granulation tissue over the osteotomy site. From the literature, it is clear that fibrous tissue growth, scarring, and granulation tissue formation during the healing process will decrease or compromise the created surface area of the osteotomy site, leading to surgical failure [1, 2]. Also, the healing process has the potential to promote adhesion of the osteotomy to the middle turbinate and septum, or induce obstruction of the common canaliculus [3]. Thus, if we can inhibit fibrous tissue growth and scarring by applying anti-proliferative agents over the anastomosed flaps and osteotomy site, the failure rate may be minimized [4].


Middle Turbinate Osteotomy Site Nasolacrimal Duct Obstruction Extensive Cell Death Silicone Intubation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer India 2015

Authors and Affiliations

  1. 1.Department of OphthalmologyZhongshan Hospital and Fudan UniversityShanghaiChina

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