Quorum Sensing in Competence and Sporulation

  • Navneet RaiEmail author
  • Rewa Rai
  • K. V. Venkatesh


In several Gram-positive bacteria, competence and sporulation are few of several physiological processes controlled by quorum sensing (QS). Competence is a phenomenon wherein a bacterium acquires extracellular DNA for its maintenance. Only a fraction of cells (10–20 %), in a population, develop competence, at a particular window of growth phase, and in response upregulate expression of genes involved in the uptake and processing of extracellular DNA. Sporulation, second QS-controlled phenotype, occurs under extreme stress and nutritional scarcity. Prolonged nutrient deprivation compels the cell to enter the process of sporulation, the outcome of which is the production of a metabolically dormant endospore that resumes growth once the conditions become favorable again. Spore formation is a complex and tightly regulated phenomenon, where several hundred genes are directly and indirectly involved. Regulation of competence and sporulation is a complex and temporally regulated process. In present chapter, we will discuss QS driven regulation of competence and sporulation in different Gram-positive bacteria.


Quorum Sense Competence Development Competence Gene Quorum Sense Molecule Response Regulator Protein 
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Copyright information

© Springer India 2015

Authors and Affiliations

  1. 1.Genome CenterUniversity of California DavisDavisUSA
  2. 2.Department of ChemistryIndian Institute of Technology DelhiHauz Khas, New DelhiIndia
  3. 3.Department of Chemical EngineeringIndian Institute of Technology BombayPowai, MumbaiIndia

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