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Improvements in Adjuvants for New-Generation Vaccines

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Translational Research in Environmental and Occupational Stress

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Abstract

Over the last decade, extensive research for development of new vaccine adjuvants is being carried out. Present generation vaccines, particularly those based on recombinant proteins and DNA, are not only less reactogenic and also less immunogenic. Therefore, there is an urgent need for the development of new and improved vaccine adjuvants. Many novel adjuvants have been cleared for license, and many are in late stages of clinical trials. Recent investigations in innate immunity have offered new insights into immunostimulatory actions of adjuvants and have facilitated a more rational selection of adjuvants. Despite the impressive response of approved adjuvants in generating immunity against pathogens, there remains a need for improved adjuvants that enhance strong T-cell immunity and protective antibody response. The discovery of more potent adjuvants will also allow engineering of vaccines against infections that do not naturally elicit protective immunity. A logical approach to the development of new and more effective vaccine adjuvants requires a better understanding of the action of adjuvant-antigen formulations. Here, we discuss these advances and the need for better adjuvant development.

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Authors and Affiliations

  1. Immunomodulation Division, DIPAS, DRDO, Timarpur, New Delhi, India

    Lilly Ganju & Divya Singh

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  1. Lilly Ganju
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  2. Divya Singh
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Correspondence to Lilly Ganju .

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  1. Defence Institute of Physiology and Allied Sciences (DIPAS), New Delhi, Delhi, India

    Shashi Bala Singh

  2. Department of Medicine and Director for Systems, The University of Chicago, Chicago, USA

    Nanduri R. Prabhakar

  3. Department of Anaesthesiology, School of Medicine, State University of New York, Stony Brook, New York, USA

    Srinivas N Pentyala

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Ganju, L., Singh, D. (2014). Improvements in Adjuvants for New-Generation Vaccines. In: Singh, S., Prabhakar, N., Pentyala, S. (eds) Translational Research in Environmental and Occupational Stress. Springer, New Delhi. https://doi.org/10.1007/978-81-322-1928-6_11

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