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Mechanisms of Chemopreventive Activity of Sulforaphane

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Perspectives in Cancer Prevention-Translational Cancer Research

Abstract

d, l-Sulforaphane (SFN) found in cruciferous vegetables is a highly promising anticancer and chemopreventive agent. SFN has been shown to exhibit cytostatic and cytotoxic activities against a number of cancer cell types in vitro and inhibit chemically induced carcinogenesis in rodent models in vivo. SFN also prevents metastasis in mouse models of different cancer types. Cytostatic and cytotoxic activities of SFN have been attributed to several mechanisms including the reactive oxygen species (ROS)-dependent cell cycle arrest and apoptosis. Recent studies discussed in this chapter strongly suggest that 4-hydroxynonenal (HNE), the most abundant end product of ROS-induced lipid peroxidation of ω-6 fatty acids, is a major contributor to the chemopreventive activity of SFN. The chemopreventive activity of SFN, and perhaps its analogs found in cruciferous plants, may be attributed to HNE-induced selective apoptosis in cancer cells and simultaneous protection of neighboring normal cells from carcinogenic insult through the induction of defense mechanisms such as the activation of Nrf2 and Hsf1.

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Acknowledgment

Supported in part by NEIHS grants ES 012171 and Patricia Rogers Joslin Foundation for Pancreatic Cancer Research, Arlington, Texas.

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  1. Department of Molecular Biology and Immunology, University of North Texas Health Science Center, 3500 Camp Bowie Blvd., Fort Worth, TX, 76107, USA

    Yogesh C. Awasthi, Shailesh Jaiswal, Mukesh Sahu, Abha Sharma & Rajendra Sharma

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  1. Yogesh C. Awasthi
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  2. Shailesh Jaiswal
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  3. Mukesh Sahu
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  4. Abha Sharma
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  5. Rajendra Sharma
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Correspondence to Yogesh C. Awasthi .

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  1. Computational Biology & Bioinformatics, University of Kerala, Kariavattom, Trivandrum, Kerala, India

    Perumana R. Sudhakaran

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Awasthi, Y.C., Jaiswal, S., Sahu, M., Sharma, A., Sharma, R. (2014). Mechanisms of Chemopreventive Activity of Sulforaphane. In: R. Sudhakaran, P. (eds) Perspectives in Cancer Prevention-Translational Cancer Research. Springer, New Delhi. https://doi.org/10.1007/978-81-322-1533-2_8

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