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Omics for Personalized Medicine pp 529–557Cite as

Pharmacogenomics of Allergy and Asthma

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Abstract

Allergy and asthma are the diseases of multifactorial etiologies increasing dramatically all over the world. Numerous factors (e.g., aeroallergen, toxin, pathogen, food, chemical insect debris, and drugs) play a key role in the pathophysiology of allergy and asthma. Recent advances in the field of genetics have led to the identification of genetic factors which are involved not only in the pathogenesis of asthma and allergy but also significantly (60–70 %) contribute toward the interindividual variability to drug response and adverse drug reactions. There are several common categories of medications for treating asthma and allergy. Significant heterogeneity in the efficacy and adverse drug reactions of anti-allergic and anti-asthmatic drugs have been observed and efforts have been made to study the role of genetic determinants in the variable interindividual response to medication. Armed with the knowledge of a patient’s pharmacogenomic information, a clinician could predict the response to certain drugs and adverse drug reactions to improve the efficacy and tolerability of the therapeutic interventions.

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Abbreviations

ABP:

Diamine oxidase

ADAM-33:

A disintegrin and metalloproteinase domain-containing protein 33

ADRB2:

Beta adrenergic receptors

ADRB-2:

Beta-2 adrenergic receptor

ADRs:

Adverse Drug Reactions

ALOX5:

Arachidonate 5 lipoxygenase

ATP:

Adenosine triphosphate

BALF:

Bronchoalveolar lavage fluid

cAMP:

Cyclic adenosine monophosphate

CCL11:

Chemokine (C-C motif) ligand 11

CD-14:

Cluster of differentiation 14 (CD14)

CFTR:

Cystic fibrosis transmembrane conductance regulator

CHRM2:

Cholinergic receptor muscarinic 2

CLCA1:

Calcium-activated chloride channel regulator 1

COX-2:

Cycloxygenase-2

CRDCP15:

Caspase recruitment domain-containing protein 15

CRHR1:

Corticotrophin-releasing hormone receptor 1

CYF1P2:

Cytoplasmic FMR1-interacting protein

CYP1A2:

Cytochrome P450 family 1 subfamily A, polypeptide 2

CYP2E1:

Cytochrome P450 family 2 subfamily E, polypeptide 1

CysLTR1:

Cysteinyl leukotriene receptor

DEFB1:

Defensin beta 1

DNA:

Deoxyribonucleic acid

DPP10:

Dipeptidyl-peptidase 10

FCER1B:

Fc epsilon receptor I beta-chain

FDA:

Food and Drug Administration

FKB51:

FK506-binding protein 51

FLG:

Flaggrin

GATA3:

Trans-acting T-Cell-specific transcription factor

GC-R:

Glucocorticoid resistant

GC-S:

Glucocorticoid sensitive

GM-CSF:

Granulocyte-macrophage colony-stimulating factor

GMCSF:

Granulocyte-monocyte colony-stimulating factor

GPRA:

G protein-coupled receptor for asthma

GSNOR:

S-Nitrosoglutathione reductase

GST:

Glutathione S-transferase

GWAS:

Genome-wide association study

HDC:

Histidine decarboxylase

hGR:

Human glucocorticoid receptor

HLA:

Human leukocyte antigen

HNM:

Histamine N-methyl transferase

HRH:

Histamine receptor

IFNG:

Interferon γ

IFNGR1:

Interferon gamma receptor-1

IgE:

Immunoglobulin E

IL:

Interleukin

IL-1β:

Interleukin-1β

ISSAC:

The International Study of Asthma and Allergies in Childhood

JAK1:

Janus kinase 1

Km:

Michaelis-Menton Constant

LABA:

Long-acting beta-2 agonists

LT:

Leukotriene

LTC4S:

Leukotriene C4 synthase

mRNA:

Messenger ribonucleic acid

NAD+ :

Nicotinamide adenine dinucleotide

NF-κB:

Nuclear factor kappa B

PARP-1:

Poly (ADP-ribose) polymerase 1

PBMC:

Peripheral blood mononuclear cells

PDE4D:

phosphodiesterase-4D

PHF-11:

Plant homeodomain finger protein 11

POSTN:

Periostin osteoblast-specific factor

RNA:

Ribonucleic acid

SABA:

Short-acting beta-2 agonists

Serpin B2:

Serpin peptidase inhibitor clade B2

SLE:

Systemic Lupus Erythematous

SNPs:

Single nucleotide polymorphisms

SPINK5:

Serine protease inhibitor kazal type 5

STAT6:

Signal transducer and activator of transcription

TBX2:

T-box transcription factor

TCγ:

T cell antigen receptor γ chain

TGF-β:

Transforming growth factor Β

TH1:

T helper 1

TH2:

T helper 2

TLR:

Toll-like receptors

TNF-α:

Tumor necrosis factor-α

Vmax:

Maximum rate of the enzyme catalyzed reaction

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Authors and Affiliations

  1. Department of Molecular Biology, Institute of Genetics and Hospital for Genetic Diseases, Osmania University, Begumpet, Hyderabad, 500016, Andhra Pradesh, India

    Anjana Munshi

  2. Department of Biochemistry, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd, Bethesda, MD, 20814, USA

    Luciana B. Crotti

  3. Institute of Genetics and Hospital for Genetic Diseases, Osmania University, Begumpet, Hyderabad, 500016, Andhra Pradesh, India

    Vandana Sharma

  4. Department of Pharmacology, Apollo Health City, Jubillee Hills, Hyderabad, Andhra Pradesh, India

    Sanjeev Sharma

  5. Department of Biochemistry and Molecular Biology & Cell Biology, Georgetown University, 3900 Reservoir Rd, Washington, DC, 20057, USA

    Luis A. Espinoza

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  1. Anjana Munshi
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  2. Luciana B. Crotti
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  3. Vandana Sharma
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  4. Sanjeev Sharma
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  5. Luis A. Espinoza
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Correspondence to Anjana Munshi .

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Editors and Affiliations

  1. Centre for Genomics & Applied Gene Technology, Institute of Integrative Omics and Applied Biotechnology (IIOAB), Purba Medinipur, West Bengal, India

    Debmalya Barh

  2. Institute of Life Sciences, B.V. Patel Pharmaceutical Education and Research Development Centre, Ahmedabad University, Ahmedabad, Gujarat, India

    Dipali Dhawan

  3. Policy Centre for Biomedical Research, Translational Health Science and Technology Institute (Department of Biotechnology Institute, Government of India), Office @ National Institute of Immunology, New Delhi, India

    Nirmal Kumar Ganguly

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Munshi, A., Crotti, L.B., Sharma, V., Sharma, S., Espinoza, L.A. (2013). Pharmacogenomics of Allergy and Asthma. In: Barh, D., Dhawan, D., Ganguly, N. (eds) Omics for Personalized Medicine. Springer, New Delhi. https://doi.org/10.1007/978-81-322-1184-6_24

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