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Neurogenetics and Nutrigenomics of Reward Deficiency Syndrome (RDS): Stratification of Addiction Risk and Mesolimbic Nutrigenomic Manipulation of Hypodopaminergic Function

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Omics for Personalized Medicine

Abstract

We have entered the genomics era with hope for the future of medicine including psychiatry. Understanding the role of DNA and polymorphic associations with brain reward circuitry has led to a new understanding of all addictive behaviors. We present here a brief review of the role of both neurogenetics and nutrigenomics as cornerstones that link more accurate genetic diagnosis and dopamine D2 agonist therapy to induce dopaminergic activation. Based on numerous experiments we are indeed proposing a novel approach. We challenge the entire recovery field to use these tools, the result of years of scientific research into the nature of addiction, and to incorporate them into treatment programs for patients attending inpatient/outpatient addiction clinics, such as the Genetic Addiction Risk Score (GARS)™ for appropriate RDS diagnosis, Comprehensive Analysis of Reported Drugs (CARD)™ to determine both compliance and abstinence during treatment, natural D2 agonistic therapy (NAAT-KB220™), and, eventually, mRNA (patent pending) to determine pre- and post-candidate gene expressions in reward deficiency syndrome (RDS). We are, therefore, proposing a paradigm shift we have called “Reward Deficiency Solutions System (RDSS)™.”

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Authors and Affiliations

  1. Department of Psychiatry, McKnight Brain Institute, College of Medicine, University of Florida, Gainesville, FL, USA

    Kenneth Blum & Eric R. Braverman

  2. G and G Holistic Addiction Treatment Center, North Miami Beach, FL, USA

    Kenneth Blum

  3. Department of Clinical Neurology, Path Foundation, New York, NY, USA

    Kenneth Blum, Raquel Lohmann & Eric R. Braverman

  4. Institute of Integrative Omics and Applied Biotechnology, Nonakuri, Purba Medinipur, West Bengal, India

    Kenneth Blum

  5. Dominion Diagnostics, LLC, North Kingstown, RI, USA

    Kenneth Blum, John Femino, Mary Hauser & Thomas Simpatico

  6. Global Integrated Services Unit, Center for Clinical and Translational Science, College of Medicine, University of Vermont, Burlington, VT, USA

    Kenneth Blum & Thomas Simpatico

  7. Department of Addiction Research and Therapy, Malibu Beach Recovery Center, Malibu Beach, CA, USA

    Kenneth Blum

  8. Department of Nutrigenomics, LifeGen, Inc., Austin, TX, USA

    Kenneth Blum, Margaret A. Madigan & B. W. Downs

  9. Department of Management Science and Statistics, University of Texas at San Antonio, San Antonio, TX, USA

    David Han

  10. Department of Holistic Medicine, G and G Holistic Addiction Treatment Center, North Miami Beach, FL, USA

    John Giordano

  11. Centre for Genomics and Applied Gene Technology, Institute of Integrative Omics and Applied Biotechnology (IIOAB), Nonakuri, Purba Medinipur, WB, India

    Debmalya Barh

  12. Meadows Edge Addiction Recovery Center, North Kingstown, RI, USA

    John Femino

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Correspondence to Kenneth Blum .

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  1. Centre for Genomics & Applied Gene Technology, Institute of Integrative Omics and Applied Biotechnology (IIOAB), Purba Medinipur, West Bengal, India

    Debmalya Barh

  2. Institute of Life Sciences, B.V. Patel Pharmaceutical Education and Research Development Centre, Ahmedabad University, Ahmedabad, Gujarat, India

    Dipali Dhawan

  3. Policy Centre for Biomedical Research, Translational Health Science and Technology Institute (Department of Biotechnology Institute, Government of India), Office @ National Institute of Immunology, New Delhi, India

    Nirmal Kumar Ganguly

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Blum, K. et al. (2013). Neurogenetics and Nutrigenomics of Reward Deficiency Syndrome (RDS): Stratification of Addiction Risk and Mesolimbic Nutrigenomic Manipulation of Hypodopaminergic Function. In: Barh, D., Dhawan, D., Ganguly, N. (eds) Omics for Personalized Medicine. Springer, New Delhi. https://doi.org/10.1007/978-81-322-1184-6_18

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