Abstract
Uterine contractility of the non-pregnant uterus is likely to play an important role in human reproduction, in particular, in the embryo implantation process. After ovulation, contractility is characterized by a relative quiescence in response to the level of progesterone produced. The development of high-resolution ultrasound probes has enabled the visualization of the myometrial activity in a non-invasive way. It can also provide additional characteristics such as amplitude and direction. The nearly quiescent contractility reached at hCG+ 7 days may favour embryo permanence in the endometrial cavity, and therefore, assist implantation. Studying and understanding contractility of the non-pregnant uterus can improve embryo transfers and implantation rates.
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Harper MJ, Chang MC. Some aspects of the biology of mammalian eggs and spermatozoa. Adv Reprod Physiol. 1971;5:167–218.
Settlage DS, Motoshima M, Tredway DR. Sperm transport from the external cervical os to the fallopian tubes in women: a time and quantitation study. Fertil Steril. 1973;24:655–61.
Kunz G, Beil D, Deininger H, Wildt L, Leyendecker G. The dynamics of rapid sperm transport through the female genital tract: evidence from vaginal sonography of uterine peristalsis and hysterosalpingoscintigraphy. Hum Reprod. 1996;11:627–32.
McLaren A, Michie D. The spacing of implantations in the mouse uterus. Mem Soc Endocr. 1959;6:65–75.
Pusey J, Kelly WA, Bradshaw JMC, Porter DG. Myometrial activity and the distribution of blastocysts in the uterus of the rat: interference by relaxin. Biol Reprod. 1980;23:394–7.
Birnholz JC. Ultrasonic visualization of endometrial movements. Fertil Steril. 1984;41:157–8.
Oike K, Obata S, Tagaki K, Matsuo K, Ishihara K, Kikuchi S. Observation of endometrial movement with transvaginal sonography. J Ultrasound Med. 1988;7:99.
Rucker MP. Contractions of a non-pregnant multiparous human uterus. Am J Obstet Gynecol. 1925;9:255.
Knaus H. Eine neue Method zur Bestimmung des Ovulationstermines. Zbl Gynaek. 1929;53:2193.
Wilson L, Kurzrok R. Studies on the motility of the human uterus in vivo. Endocrinology. 1938;23:79.
Bickers W. Uterine contraction patterns. Effect of psychic stimuli on the myometrium. Fertil Steril. 1956;7:268.
Jacobson E, Lackner JE, Sinykin MB. Electrical and mechanical activity of the human non-pregnant uterus. Am J Obstet Gynecol. 1939;38:1008.
Henry JS, Browne JSL. The contractions of the human uterus during the menstrual cycle. Am J Obstet Gynecol. 1943;45:927.
Garrett WJ. Some observations of the human myometrial cycle. J Physiol. 1956;132:553.
Csapo AI, Pinto-Dantas CR. The cyclic activity of the nonpregnant human uterus. A new method for recording intrauterine pressure. Fertil Steril. 1966;17:34–8.
Hendricks CH. Inherent motility patterns and response characteristics of nonpregnant human uterus. Am J Obstet Gynecol. 1966;96:824–43.
Martinez-Gaudio M, Yoshida T, Bengtsson LP. Propagated and nonpropagated myometrial contractions in normal menstrual cycles. Am J Obstet Gynecol. 1973;115:107–11.
Shafik A. Electrohysterogram: study of the electromechanical activity of the uterus in humans. Eur J Obstet Gynecol Reprod Biol. 1997;73:85–9.
Abramowicz JS, Archer DF. Uterine endometrial peristalsis-a transvaginal ultrasound study. Fertil Steril. 1990;54:451–4.
Lyons EA, Taylor PJ, Zheng XH, Ballard G, Levi CS, Kredentser JV. Characterization of subendometrial myometrial contractions throughout the menstrual cycle in normal fertile women. Fertil Steril. 1991;55:771–4.
Bulletti C, de Ziegler D, Polli V, Diotallevi L, Del Ferro E, Flamigni C. Uterine contractility during the menstrual cycle. Hum Reprod. 2000;15:81–9.
Fanchin R, Righini C, Olivennes F, Taylor S, de Ziegler D, Frydman R. Uterine contractions at the time of embryo transfer alter pregnancy rates after in-vitro fertilization. Hum Reprod. 1998;13:1968–74.
Fanchin R, Ayoubi JM, Olivennes F, Righini C, de Ziegler D, Frydman R. Hormonal influence on the uterine contractility during controlled ovarian hyperstimulation. Hum Reprod. 2000;15:90–100.
Ayoubi JM, Fanchin R, Kaddouz D, Frydman R, de Ziegler D. Uterorelaxing effects of vaginal progesterone: comparison of two methodologies for assessing uterine contraction frequency on ultrasound scans. Fertil Steril. 2001;76:736–40.
Ijland MM, Evers JL, Dunselman GA, van Katwijk C, Lo CR, Hoogland HJ. Endometrial wavelike movements during the menstrual cycle. Fertil Steril. 1996;65:746–9.
Krohn L, Lackner JE, Soskin S. The effect of the ovarian hormones on human (nonpuerperal) uterus. Am J Obstet Gynecol. 1937;34:379.
Henry JS, Browne JSL, Venning EH. Some observations on the relations of estrogens and progesterone to the contractions of the non-pregnant and pregnant human uterus. Am J Obstet Gynecol. 1950;60:471.
Cibils LA. Contractility of the nonpregnant human uterus. Obstet Gynecol. 1967;30(3):441–61.
Bickers W. Uterine contractions in dysmenorrhea. Am J Obstet Gynecol. 1941;42:1023.
Eskes TK, Hein PR, Stolte LA, Kars-Villanueva EB, Crone A, Braaksma JT, Janssens J. Influence of dydrogesterone on the activity of the nonpregnant human uterus. Am J Obstet Gynecol. 1970;106:1235–41.
Bulletti C, Prefetto RA, Bazzocchi G, Romero R, Mimmi P, Polli V, Lanfranchi GA, Labate AM, Flamigni C. Electromechanical activities of human uteri during extra-corporeal perfusion with ovarian steroids. Hum Reprod. 1993;8:1558–63.
Hunter RH. Human fertilization in vivo, with special reference to progression, storage and release of competent spermatozoa. Hum Reprod. 1987;2:329–32.
Brown SE, Toner JP, Schnorr JA, Williams SC, Gibbons WE, de Ziegler D, Oehninger S. Vaginal misoprostol enhances intrauterine insemination. Hum Reprod. 2001;16:96–101.
Coutinho EM, Maia HS. The contractile response of the human uterus, fallopian tubes, and ovary to prostaglandins in vivo. Fertil Steril. 1971;22:539–43.
Knutzen V, Stratton CJ, Sher G, McNamee PI, Huang TT, Soto-Albors C. Mock embryo transfer in early luteal phase, the cycle before in vitro fertilization and embryo transfer: a descriptive study. Fertil Steril. 1992;57:156–62.
IJland MM, Evers JL, Dunselman GA, Volovics L, Hoogland HJ. Relation between endometrial wavelike activity and fecundability in spontaneous cycles. Fertil Steril. 1997;67:492–6.
Miles RA, Paulson RJ, Lobo RA, Press MF, Dahmoush L, Sauer MV. Pharmacokinetics and endometrial tissue levels of progesterone after administration by intramuscular and vaginal routes: a comparative study. Fertil Steril. 1994;62:485–90.
Fanchin R, De Ziegler D, Bergeron C, Righini C, Torrisi C, Frydman R. Transvaginal administration of progesterone. Obstet Gynecol. 1997;90:396–401.
de Ziegler D, Bulletti C, De Monstier B, Jaaskelainen AS. The first uterine pass effect. Ann N Y Acad Sci. 1997;828:291–9.
Cicinelli E, de Ziegler D, Bulletti C, Matteo MG, Schonauer LM, Galantino P. Direct transport of progesterone from vagina to uterus. Obstet Gynecol. 2000;95:403–6.
Fanchin R, Righini C, de Ziegler D, Olivennes F, Lédée N, Frydman R. Effects of vaginal progesterone administration on uterine contractility at the time of embryo transfer. Fertil Steril. 2001;75(6):1136–40.
Fanchin R, Ayoubi JM, Righini C, Olivennes F, Schönauer LM, Frydman R. Uterine contractility decreases at the time of blastocyst transfers. Hum Reprod. 2001;16:1115–9.
Gardner DK, Vella P, Lane M, Wagley L, Schlenker T, Schoolcraft WB. Culture and transfer of human blastocysts increases implantation rates and reduces the need for multiple embryo transfers. Fertil Steril. 1998;69:84–8.
Menezo Y, Veiga A, Benkhalifa M. Improved methods for blastocyst formation and culture. Hum Reprod. 1998;13 Suppl 4:256–65.
Milki AA, Fisch JD, Behr B. Two-blastocyst transfer has similar pregnancy rates and a decreased multiple gestation rate compared with three-blastocyst transfer. Fertil Steril. 1999;72:225–8.
Pierzynski P, Reinheimer TM, Kuczynski W. Oxytocin antagonists may improve infertility treatment. Fertil Steril. 2007;88:213.e19-22.
Kido A, Togashi K, Hatayama H. Uterine peristalsis in women with repeated IVF failures: possible therapeutic effect of hyoscine bromide. J Obstet Gynaecol Can. 2009;31(8):732–5.
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Sebag-Peyrelevade, S., Fanchin, R. (2015). Uterine Contractility and Embryo Transfer. In: Allahbadia, G., Chillik, C. (eds) Human Embryo Transfer. Springer, New Delhi. https://doi.org/10.1007/978-81-322-1115-0_8
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DOI: https://doi.org/10.1007/978-81-322-1115-0_8
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