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Melatonin’s Role in Human Reproduction: Recent Studies

  • Rahimah ZakariaEmail author
  • Amnon Brzezinski
  • Venkataramanujam Srinivasan
Chapter

Abstract

Melatonin, N-acetyl-5-methhoxytryptamine, is a molecule with diverse physiological function. It affects reproductive functions in a wide variety of species. This chapter describes the roles of melatonin on various reproductive parameters. Melatonin has an inhibitory influence on hypothalamic GnRH secretion. Melatonin acts as antioxidant and reduces oxidative stress-induced testicular dysfunctions and poor oocytes quality in many experimental animals. During fetal life, melatonin regulates circadian rhythm and has been suggested to play a role in the regulation of fetal REM and NREM sleep. In adults, melatonin regulates the time of parturition in both humans and nonhuman primates. Many studies have suggested that melatonin could be an effective treatment for preeclampsia, due to its antioxidant properties as well as its antihypertensive and anticonvulsive actions.

Keywords

Melatonin GnRH Parturition Oocyte Testes Preeclampsia 

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Copyright information

© Springer India 2014

Authors and Affiliations

  • Rahimah Zakaria
    • 1
    Email author
  • Amnon Brzezinski
    • 2
  • Venkataramanujam Srinivasan
    • 3
    • 4
    • 5
  1. 1.Department of PhysiologySchool of Medical Sciences, Universiti Sains MalaysiaKubang Kerian, KelantanMalaysia
  2. 2.Department of Obstetrics and GynecologyHadassah Hebrew-University Medical CenterJerusalemIsrael
  3. 3.Sri Sathya Sai Medical Educational and Research Foundation, An International Medical Sciences Research Study CenterCoimbatoreIndia
  4. 4.National Health Service, Department of Mental Health, Psychiatric Service of Diagnosis and TreatmentHospital “G. Mazzini”TeramoItaly
  5. 5.Department of Neuroscience and ImagingUniversity “G.D’ Annunzio”ChietiItaly

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