Abstract
Potential ramifications of climate change, as they relate to waterborne pathogens (primarily viruses, bacterial and parasitic protozoa), are the focus of this chapter. It seems clear that climate change will impact on waterborne pathogens in various ways (Rose et al. 2001), pertinent to transboundary issues are: (1) increases in intense storm events (increasing sewage/animal waste flows into waterways/aquifers) (Charron et al. 2004; Schijven and de Roda Husman 2005; Yang and Goodrich 2009; De Toffol et al. 2009; Richardson et al. 2009); (2) warmer surface water temperatures or salinity changes (for increased autochthonous pathogen growth) (Niemi et al. 2004; Koelle et al. 2005; Lebarbenchon et al. 2008); and (3) changes in food production, as most obvious in animal diseases (Lightner et al. 1997; Rapoport and Shimshony 1997), but also of concern with zoonoses and from changes in social behavior (Schwab et al. 1998; Nancarrow et al. 2008; CDC 2009a). When considering trans-boundary effects on waterborne pathogens, it is therefore the flow of pathogens in surface water (fresh and marine) and in groundwater, as well as in the varying ways water is used/reused in association with human activities (e.g., food production) that are the trans-boundary issues discussed in this chapter (examples in Table 5.1). Changes in infectious and vector-borne diseases associated with rising sea levels, losses of habitat, international travel etc. are not addressed in this chapter.
The views expressed in this chapter are those of the author and do not necessarily reflect the views or policies of the US Environmental Protection Agency. Mention of trade names or commercial products does not constitute Agency endorsement or recommendation for use.
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Introduction
Potential ramifications of climate change, as they relate to waterborne pathogens (primarily viruses, bacterial and parasitic protozoa), are the focus of this chapter. It seems clear that climate change will impact on waterborne pathogens in various ways (Rose et al. 2001), pertinent to transboundary issues are: (1) increases in intense storm events (increasing sewage/animal waste flows into waterways/aquifers) (Charron et al. 2004; Schijven and de Roda Husman 2005; Yang and Goodrich 2009; De Toffol et al. 2009; Richardson et al. 2009); (2) warmer surface water temperatures or salinity changes (for increased autochthonous pathogen growth) (Niemi et al. 2004; Koelle et al. 2005; Lebarbenchon et al. 2008); and (3) changes in food production, as most obvious in animal diseases (Lightner et al. 1997; Rapoport and Shimshony 1997), but also of concern with zoonoses and from changes in social behavior (Schwab et al. 1998; Nancarrow et al. 2008; CDC 2009a). When considering trans-boundary effects on waterborne pathogens, it is therefore the flow of pathogens in surface water (fresh and marine) and in groundwater, as well as in the varying ways water is used/reused in association with human activities (e.g., food production) that are the trans-boundary issues discussed in this chapter (examples in Table 5.1). Changes in infectious and vector-borne diseases associated with rising sea levels, losses of habitat, international travel etc. are not addressed in this chapter.
Areas of Potential Impact by Climate Change
One of the largest effects of climate change is likely to be reflected in changes in water resource use, which will need to account for water’s equally important roles in electricity production/greenhouse gas production (King and Webber 2008) and ecological service provision (Corvalan et al. 2005; Keath and Brown 2009) so as to provide more sustainable water services into the future. A likely consequence of these changed services is an increase in the use of water fit-for-purpose. For example, where there is municipal water supply, not treating all to drinking water quality, give that less than 10% is required in the home for that purpose (Rathjen et al. 2003). Rather, for other urban and irrigation needs, there will be increased use of recycled wastewater streams for toilet flushing, garden/crop irrigation and cloths washing, so reducing the demand on traditional urban water resources (possibly up to 70%) and keeping environmental water to support ecological services and reduce trans-boundary effects of water pollution.
At a regional scale and in developed regions, climate change is already having a profound impact on water decisions within Australia (WSAA 2008), and is expected to have major impacts in many other regions. For example, Californian water resources are projected to significantly change with respect to snowpack, river flows, and sea levels. By 2050, it is predicted that the Sierra snowpack will decline by 25%, which is an important source of urban, agricultural, and environmental water (California Department of Water Resources 2009). More variable weather patterns may also result in increased dryness in the southern regions of California. The sea level has risen about 7 inches at the Golden Gate Bridge in the last century, and continued sea level rise could threaten many coastal communities, as well as the sustainability of the Sacramento-San Joaquin Delta that supplies 25 million Californians with drinking water. As a consequence, water reuse has to increase, most likely via a second non-potable supply pipe to homes (Okum 2002) and/or through wastewater irrigation (direct or via aquifer storage and recovery) (Kracman et al. 2001; Dillon et al. 2009), which will open up new ecological niches for waterborne pathogens.
An example of the possible effects of climate change on waterborne pathogens in developing regions can be seen in the increases in diarrheal disease during El Niño periods in Peru. For each 1°C increase in temperature, hospital admission increased by 8% (95% CI 7–9%), with an additional 6,225 cases of diarrheal disease recorded (Checkley et al. 2000). In Fiji, diarrheal disease appears to increase by 3% (95% CI 1.2–5.0%) per 1°C temperature increase, noting also that a significant increase in diarrhea rates occurred if rainfall was either higher or lower than average conditions (Singh et al. 2001). Overall in developing regions, water, sanitation and hygiene-related disease currently account for some 5.5% of total disability adjusted life years (DALYs) lost (Prüss-Üstün et al. 2008). Changes in diarrheal disease has been the main metric used in WHO reports on possible climate change impacts related to waterborne disease (McMichael et al. 2004; Campbell-Lendrum and Woodruff 2006). What is not clear from most reports, however, are the trans-boundary effects, let alone the raft of other diseases unrelated to diarrhea (e.g., see Table 5.2 and Niklasson et al. 1998; Blinkova et al. 2009). For example, given the increase in aquaculture produce from developing regions, what may be the impact on countries that purchase these products for increased diarrhea and other disease endpoints?
Globally, some 70% of environmental water withdrawals are used in agriculture (Millennium Assessment Board 2005). The need to reduce the total demand but feed the world is probably the biggest global water issue, and the Israelis are leading the world in demonstrating one solution via drip irrigation of treated municipal wastewaters (Oron et al. 2001). Given the globalization of food products, however, numerous disease outbreaks have been recorded for other situations when crops eaten raw are spray irrigated with poorly treated water (Rose et al. 2001; Jay et al. 2007; CDC 2009b). The latter is of particular concern with zoonotic pathogens in surface water (Bharti et al. 2003; Fayer 2004; Bednarska et al. 2007; Mattison et al. 2007; Moulin-Schouleur et al. 2007; Zell et al. 2008; Banyai et al. 2009; Robertson 2009; Rutjes et al. 2009), which includes viruses, bacteria and parasitic protozoa (Table 5.2).
Pathogen Dynamics and Problematic Identifications
Before going into details on the range of waterborne and water-based pathogens of concern, two points are important to note. Firstly, pathogens are dynamic in their ability to evolve and change in their potential to be human pathogens, as exemplified by seasonal changes in flu viruses. Secondly, as we use better methods (largely molecular-based) difficult to culture or non-culturable pathogens are being identified which were previously missed. Hence, it would be fair to say that there are many pathogens yet to be identified today (Rosario et al. 2009; Victoria et al. 2009), let alone what may evolve tomorrow, in part reflecting new environmental conditions.
As an example of the difficulty in describing human pathogens one can look at members of the important waterborne parasitic protozoan genus Cryptosporidium. Most human illness is thought to be due to C. hominis and C. parvum (cattle genotype), yet several other Cryptosporidium species or genotypes: C. meleagridis; C. felis; C. canis; C. suis; C. muris; C. andersoni; C. hominis monkey genotype; C. parvum (mouse genotype); C. parvum (pig genotype II) and Cryptosporidium rabbit genotype have caused human illness (Kváč et al. 2009). So how to target the right species? In a similar way but at the strain level within a species, Escherichia coli O157:H7 has been the focus of method development and study, due to numerous water- and food-borne outbreaks. Yet focusing on O157:H7 strains appears to be at the detriment of missing the even more important non-O157 shiga toxin-producing E. coli(Bettelheim 2007; Lathrop et al. 2009). The situation is further complicated in E. coli, which is probably better described as pangenomic (i.e. not a single isolated species, but one that shares many genes amongst a broader range of related members) that includes the six known pathovars, each of which may have separately inherited particular virulence factors (Rasko et al. 2008).
The Waterborne Pathogens
Waterborne pathogens are defined as disease-causing organisms excreted in feces/urine and ingested/inhaled with water. They are often referred to as being transmitted via the fecal-oral route (Ashbolt et al. 2001). All of these pathogens can persist to varying degrees in the aquatic environment, but rarely grow outside the host organism(s) they come from. Hence they are introduced and pass through the water environment as allochthonous members. Most waterborne pathogens that infect humans come from human excreta, other mammals or birds (Table 5.2).
In contrast to the fecally-borne pathogens, there are a number of water-based pathogens generally unrelated to fecal contamination, but loosely referred to as waterborne. Examples of these autochthonous or indigenous pathogens are various Legionellain saline waters. The bacterium that causes cholera (V. cholerae) is a good example of a species with members that are transmitted by the fecal-oral route, but that also have a natural life-cycle associated with marine zooplankton (Blokesch and Schoolnik 2007). It also seems that Legionella pneumophila serogroup 1, and similar respiratory pathogens, are accidental human pathogens, with various amoebae possibly acting as their main environmental host (Lau and Ashbolt 2009). Unfortunately our lung macrophages are very similar host cells to amoebae, and these Legionella-like intracellular pathogens can also parasitize our lung macrophages (Thomas et al. 2008).
Changing Habitats
In diverse regions around the world, enteric (gastrointestinal) diseases show evidence of significant seasonal fluctuations, e.g.,
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In Scotland and Sweden, Campylobacterinfections are characterized by short peaks in the spring (associated with snowmelt periods)
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In Bangladesh, cholera outbreaks occur during the monsoon season
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In Peru, Cyclospora infections peak in the summer and subside in the winter
Therefore, further extension of “seasonal” effects under climate change is likely to yield further peaks in waterborne diseases. Climatic-related peaks are also common with various autochthonous (indigenous) pathogens, such as marine Vibriovulnificus. Highest concentrations of V. vulnificus and increases in shellfish-borne human disease have been recorded in Florida following heavy rainfall associated with El Niño events (Lipp et al. 2001). It appears that reduced salinity due to increased freshwater inputs rather than temperature is the key factor increasing the competitive advantage of V. vulnificus.
Which Water-Based (Autochthonous) Microbes Are Pathogens?
A common feature of the autochthonous (and allochthonous) bacterial pathogens, is that not all strains of pathogenic species are effective human pathogens. For example, in a three-year study of environmental and clinical Vibriovulnificus isolates, the more important biotype 3 sub-species represented about 21% of the aquaculture pond isolates versus 86% of clinical cases (Broza et al. 2009). Huge quantities of aquacultural produce are now exported around the world for direct human consumption as well as animal feedstock – their global significance to disease is largely unknown. Indeed, it is often unclear where foodstock or feeds have come from. However, what is clear is the uptake and release of ship ballast waters being responsible for the reintroduction of cholera into South America in the early 1990s (McCarthy and Khambaty 1994; WHO 2003), and ballast waters in general continue to be a problem for introductions of various toxic dinoflagellates (algae), cyanobacteria and V. parahaemolyticus (Myers et al. 2003; Tang and Dobbs 2007).
Identifying what are important biotypes is also at the heart of the issue with trying to determine the clinical significance of the common occurrence of Mycobacteriumavium complex mycobacteria (Falkinham III 2009) and Helicobacterpylori (stomach ulcer and cancer bacterium) (Kawaguchi et al. 2009). Water appears to be a likely vehicle for the exposure of people to these pathogens, but it is currently unclear if water is the primary source or much less important. Interestingly, various mycobacteria seem to be selected in chlorinated waters, possibly due to their relatively slow growth rates and biofilm-forming habitat.
Transfer of Virulence and Antibiotic Resistance Genes
5.3.2.1 V. cholerae as a Model
Understanding the ecology of V. cholerae; i.e., its ability to uptake virulence factors from bacteriophages (viruses to bacteria), growth in association with marine plankton and how it is impacted by climatic conditions, has served as a good model for trans-boundary waterborne pathogens and possible climate change impacts (Lipp et al. 2002). The marine life-cycle of V. choleraeis now well established and illustrated in Fig. 5.1.
The cholera toxin (CT), which is responsible for the classic symptom of profuse diarrhea, is encoded by a lysogenic bacteriophage designated CTX Phi (includes six toxin genes which also occur on a plasmid) (Faruque et al. 1998). V. cholerae, requires two coordinately regulated factors for full virulence, cholera toxin (CT) and toxin-coregulated pill (TCP, surface organelles required for intestinal colonization and the site for phage attachment). Hence, the emergence of toxigenic V. cholerae involves horizontal gene transfer, in vivo gene expression and follows phage seasonality. In marine waters V. cholerae becomes resistant to the phage, yet in the intestine it remains susceptible and hence, maintains its virulence (Zahid et al. 2008). Also, V. choleraeis commensal to phytoplankton and their consumers zooplankton, notably copepods, as such it is also a vector-borne disease. Interestingly, growth of V. cholerae on the chitinous exoskeletons of copepods molts induces competence for natural transformation, a mechanism for intra-species gene exchange (Blokesch and Schoolnik 2007).
A further point of some controversy is that toxigenic V. cholerae are rarely isolated from the aquatic environment between cholera epidemics, due to their presumed presence in a dormant stage, i.e., active but nonculturable (ABNC) form (Colwell et al. 1996). Nonetheless, the aquatic biofilms rather than surrounding seawater, have proved to be a source of culturable V. cholerae, even in non-epidemic periods in Bangladesh (Zahid et al. 2008).
Integrons and Antibiotic Resistance
The last example of trans-boundary pathogen concern provided in this chapter relates to the insidious perfusion of antibiotic resistant genes in the environment. Most β-Proteobacteria (members of Gram-negative bacteria that includes many pathogens and non-pathogens) contain integrons. Class 1 integrons are central players in the worldwide problem of antibiotic resistance, because they can capture and express diverse resistance genes. In addition, they are often embedded in promiscuous plasmids and transposons, facilitating their lateral transfer into a wide range of pathogens and environmental bacteria (Gillings et al. 2008).
Hence, Gillings et al. (2008) have promoted the need to understand the origin of integrons as important for the practical control of antibiotic resistance and for exploring how lateral gene transfer can seriously impact on, and be impacted by, human activities. They have shown that class 1 integrons are common in nonpathogenic soil and freshwater β-Proteobacteria in the absence of antibiotic resistance genes, yet are almost identical to the core of the class 1 integrons now found in pathogens, suggesting that environmental β-Proteobacteria were the original source of these genetic elements. Because these elements appear to be readily mobilized, their lateral transfer into human commensals and pathogens was inevitable, especially given their intersect with the human food chain. The strong selection pressure imposed by the human use of antimicrobial compounds then ensured their fixation and global spread into new species (Hardwick et al. 2008; Gillings et al. 2009). Hence, changing food production practices influenced by population growth, water resources and climate change will further impact on our loss of efficacy in antibiotics. Newer treatment systems for wastewater are also not completely effective at removing resistance genes (Bockelmann et al. 2009) and intensive animal facilities are a likely hotspot for exchange of antibiotic resistance genes (Kozak et al. 2009; Toomey et al. 2009).
References
Ashbolt NJ, Grabow WOK, Snozzi M (2001) Indicators of microbial water quality. In: Fewtrell L, Bartram J (eds) Water quality: guidelines, standards and health risk assessment and management for water-related infectious disease. IWA, London, pp 289–315 (Chapter 13)
Banyai K, Bogdan A, Domonkos G, Kisfali P, Molnar P, Toth A, Melegh B, Martella V, Gentsch JR, Szucs G (2009) Genetic diversity and zoonotic potential of human rotavirus strains, 2003–2006, Hungary. J Med Virol 81:362–370
Bednarska M, Bajer A, Sinski E, Girouard AS, Tamang L, Graczyk TK (2007) Fluorescent in situ hybridization as a tool to retrospectively identify Cryptosporidium parvum and Giardia lamblia in samples from terrestrial mammalian wildlife. Parasitol Res 100:455–460
Bettelheim KA (2007) The non-O157 shiga-toxigenic (verocytotoxigenic) Escherichia coli; under-rated pathogens. Crit Rev Microbiol 33:67–87
Bharti AR, Nally JE, Ricaldi JN, Matthias MA, Diaz MM, Lovett MA, Levett PN, Gilman RH, Willig MR, Gotuzzo E, Vinetz JM (2003) Leptospirosis: a zoonotic disease of global importance. Lancet Infect Dis 3:757–771
Blinkova O, Kapoor A, Victoria J, Jones M, Wolfe N, Naeem A, Shaukat S, Sharif S, Alam MM, Angez M, Zaidi S, Delwart EL (2009) Cardioviruses are genetically diverse and cause common enteric infections in South Asian children. J Virol 83:4631–4641
Blokesch M, Schoolnik GK (2007) Serogroup conversion of Vibrio cholerae in aquatic reservoirs. PLoS Pathog 3:e81. doi:https://doi.org/10.1371/journal.ppat.0030081
Bockelmann U, Dorries HH, Ayuso-Gabella MN, Salgot de Marcay M, Tandoi V, Levantesi C, Masciopinto C, Van Houtte E, Szewzyk U, Wintgens T, Grohmann E (2009) Quantitative PCR monitoring of antibiotic resistance genes and bacterial pathogens in three European artificial groundwater recharge systems. Appl Environ Microbiol 75:154–163
Broza YY, Danin-Poleg Y, Lerner L, Valinsky L, Broza M, Kashi Y (2009) Epidemiologic study of Vibrio vulnificus infections by using variable number tandem repeats. Emerg Infect Dis 15:1282–1285
California Department of Water Resources (2009) Urban water use efficiency. In: California water plan update 2009. Resource management strategies, vol 2. California Department of Water Resources, Sacramento, p 79 (Chapter 3)
Campbell-Lendrum D, Woodruff R (2006) Comparative risk assessment of the burden of disease from climate change. Environ Health Perspect 114:1935–1941
CDC (2009a) Multistate outbreaks of Salmonella infections associated with live poultry–United States, 2007. Morb Mortal Wkly Rep 58:25–29
CDC (2009b) Surveillance for foodborne disease outbreaks – United States, 2006. Morb Mortal Wkly Rep 58:609–636
Charron D, Thomas M, Waltner-Toews D, Aramini J, Edge T, Kent R, Maarouf A, Wilson J (2004) Vulnerability of waterborne diseases to climate change in Canada: a review. J Toxicol Environ Health 67:1667–1677
Checkley W, Epstein LD, Gilman RH, Figueroa D, Cama RI, Patz JA, Black RE (2000) Effect of El Niño and ambient temperature on hospital admissions for diarrhoeal diseases in Peruvian children. Lancet 355:442–450
Chung H, Sobsey MD (1993) Comparative survival of indicator viruses and enteric viruses in seawater and sediments. Water Sci Technol 27:425–428
Colwell RR, Brayton P, Herrington D, Tall B, Huq A, Levine MM (1996) Viable but non culturable Vibrio cholerae 01 revert to a cultivable state in the human intestine. World J Microbiol Biotechnol 12:28–31
Corvalan C, Hales S, McMichael A (2005) Ecosystems and human well-being: health synthesis: a report of the Millennium Ecosystem Assessment. World Health Organization, Geneva
De Toffol S, Laghari AN, Rauch W (2009) Are extreme rainfall intensities more frequent? Analysis of trends in rainfall patterns relevant to urban drainage systems. Water Sci Technol 59:1769–1776
Dillon P, Pavelic P, Page D, Beringen H, Ward J (2009) Managed aquifer recharge: an introduction. Waterlines report no 13 – February 2009. National Water Commission, Australian Government, Canberra
Evison LM (1988) Comparative studies in the survival of indicator organisms and pathogens in fresh and sea water. Water Sci Technol 20:309–315
Falkinham JO III (2009) Surrounded by mycobacteria: nontuberculous mycobacteria in the human environment. J Appl Microbiol 107:356–367
Faruque SM, Albert MJ, Mekalanos JJ (1998) Epidemiology, genetics, and ecology of toxigenic Vibrio cholerae [Review]. Microbiol Mol Biol Rev 62:1301–1314
Fayer R (2004) Cryptosporidium: a water-borne zoonotic parasite. Vet Parasitol 126:37–56
Fenollar F, Trape JF, Bassene H, Sokhna C, Raoult D (2009) Tropheryma whipplei in fecal samples from children, Senegal. Emerg Infect Dis 15:922–924
Gillings M, Boucher Y, Labbate M, Holmes A, Krishnan S, Holley M, Stokes HW (2008) The evolution of class 1 integrons and the rise of antibiotic resistance. J Bacteriol 190:5095–5100
Gillings MR, Xuejun D, Hardwick SA, Holley MP, Stokes HW (2009) Gene cassettes encoding resistance to quaternary ammonium compounds: a role in the origin of clinical class 1 integrons? ISME J 3:209–215
Gantzer C, Dubois E, Crance JM, Billaudel S, Kopecka H, Schwartzbrod L, Pommepuy M, Le Guyader F (1998) Influence of environmental factors on the survival of enteric viruses in seawater. Oceanol Acta 21(6):983–992 (French)
Hallegraeff GM (1992) Harmful algal blooms in the Australian region. Mar Pollut Bull 25:5–8
Hardwick SA, Stokes HW, Findlay S, Taylor M, Gillings MR (2008) Quantification of class 1 integron abundance in natural environments using real-time quantitative PCR. FEMS Microbiol Lett 278:207–212
Jay MT, Cooley M, Carychao D, Wiscomb GW, Sweitzer RA, Crawford-Miksza L, Farrar JA, Lau DK, O’Connell J, Millington A, Asmundson RV, Atwill ER, Mandrell RE (2007) Escherichia coli O157:H7 in feral swine near spinach fields and cattle, central California coast. Emerg Infect Dis 13:1908–1911
Kawaguchi K, Matsuo J, Osaki T, Kamiya S, Yamaguchi H (2009) Prevalence of Helicobacter and Acanthamoeba in natural environment. Lett Appl Microbiol 48:465–471
Keath NA, Brown RR (2009) Extreme events: being prepared for the pitfalls with progressing sustainable urban water management. Water Sci Technol 59:1271–1280
King CW, Webber ME (2008) The water intensity of the plugged-in automotive economy. Environ Sci Technol 42:4305–4311
Koelle K, Pascual M, Yunus M (2005) Pathogen adaptation to seasonal forcing and climate change. Proceedings in biological science 272:971–977
Kozak GK, Boerlin P, Janecko N, Reid-Smith RJ, Jardine C (2009) Antimicrobial resistance in Escherichia coli isolates from swine and wild small mammals in the proximity of swine farms and in natural environments in Ontario, Canada. Appl Environ Microbiol 75:559–566
Kracman B, Martrin R, Sztajnbok P (2001) The Virginia pipeline: Australia’s largest water recycling project. Water Sci Technol 43(10):35–42
Kváč M, Květoňová D, Sak B, Ditrich O (2009) Cryptosporidium pig genotype II in immunocompetent man. Emerg Infect Dis 15:982–983
Lathrop S, Edge K, Bareta J (2009) Shiga toxin-producing Escherichia coli, New Mexico, USA, 2004–2007. Emerg Infect Dis 15:1289–1291
Lau HY, Ashbolt NJ (2009) The use of Acanthamoeba as a tool for understanding Legionella pathogenesis: implications for drinking water. J Appl Microbiol 107:368–378
Lebarbenchon C, Brown SP, Poulin R, Gauthier-Clerc M, Thomas F (2008) Evolution of pathogens in a man-made world. Mol Ecol 17:475–484
Lightner DV, Redman RM, Poulos BT, Nunan LM, Mari JL, Hasson KW (1997) Risk of spread of penaeid shrimp viruses in the Americas by the international movement of live and frozen shrimp. Rev Sci Tech 16:146–160
Lipp EK, Huq A, Colwell RR (2002) Effects of global climate on infectious disease: the cholera model. Clin Microbiol Rev 15:757–770
Lipp EK, Rodrigues-Palacios C, Rose JB (2001) Occurrence and distribution of the human pathogen Vibrio vulnificus in a subtropical Gulf of Mexico estuary. Hydrobiologiea 460:165–173
Mattison K, Shukla A, Cook A, Pollari F, Friendship R, Kelton D, Bidawid S, Farber JM (2007) Human Noroviruses in swine and cattle. Emerg Infect Dis 13:1184–1188
McCarthy SA, Khambaty FM (1994) International dissemination of epidemic Vibrio cholerae by cargo ship ballast and other nonpotable waters. Appl Environ Microbiol 60:2597–2601
McMichael A, Campbell-Lendrum DH, Kovats RS, Edwards S, Wilkinson P, Wilson T et al (2004) Climate change. In: Ezzati M, Lopez A, Rodgers A, Murray C (eds) Comparative quantification of health risks: global and regional burden of disease due to selected major risk factors. World Health Organization, Geneva, pp 1543–1649
McNeill AR (ed) (1985) Microbiological water quality criteria: a review for Australia. Australian water resource council technical report no 85. Australian Government Publishing Service, Canberra, 561 pages
Millennium Assessment Board (2005) Living beyond our means: natural assets and human well-being, Millennium Ecosystem Assessment. http://www.millenniumassessment.org/en/Index.aspx
Moulin-Schouleur M, Reperant M, Laurent S, Bree A, Mignon-Grasteau S, Germon P, Rasschaert D, Schouler C (2007) Extraintestinal pathogenic Escherichia coli strains of avian and human origin: link between phylogenetic relationships and common virulence patterns. J Clin Microbiol 45:3366–3376
Myers ML, Panicker G, Bej AK (2003) PCR detection of a newly emerged pandemic Vibrio parahaemolyticus O3:K6 pathogen in pure cultures and seeded waters from the Gulf of Mexico. Appl Environ Microbiol 69:2194–2200
Nancarrow BE, Leviston Z, Po M, Porter NB, Tucker DI (2008) What drives communities’ decisions and behaviours in the reuse of wastewater. Water Sci Technol 57:485–491
Niemi G, Wardrop D, Brooks R, Anderson S, Brady V, Paerl H, Rakocinski C, Brouwer M, Levinson B, McDonald M (2004) Rationale for a new generation of indicators for coastal waters. Environ Health Perspect 112:979–986
Niklasson B, Hörnfeldt B, Lundman B (1998) Could myocarditis, insulin-dependent diabetes mellitus and Guillain-Barré‚ syndrome be caused by one or more infectious agents carried by rodents? Emerg Infect Dis 4:187–193
Okum DA (2002) Water reuse introduces the need to integrate both water supply and wastewater management at local and regulatory levels. Water Sci Technol 46(6–7):273–280
Oron G, Armon R, Mandelbaum R, Manor Y, Campos C, Gillerman L, Salgot M, Gerba C, Klein I, Enriquez C (2001) Secondary wastewater disposal for crop irrigation with minimal risks. Water Sci Technol 43(10):139–146
Prüss-Üstün A, Bos R, Gore F, Bartram J (2008) Safer water, better health. World Health Organization, Geneva
Rapoport E, Shimshony A (1997) Health hazards to the small ruminant population of the Middle East posed by the trade of sheep and goat meat. Rev Sci Tech 16:57–64
Rasko DA, et al. (2008) The pangenome structure of Escherichia coli: comparative genomic analysis of E. coli commensal and pathogenic isolates. J Bacteriol 190:6881–6893
Rathjen D, Cullen P, Ashbolt N, Cunliffe D, Langford J, Listowski A, McKay J, Priestley T, Radcliffe J (2003) Recycling water for our cities. Report to Prime Minister’s Science, Engineering and Innovation Council (PMSEIC), 28th November 2003. Federal Government of Australia, Canberra
Richardson HY, Nichols G, Lane C, Lake IR, Hunter PR (2009) Microbiological surveillance of private water supplies in England – the impact of environmental and climatefactors on water quality. Water Res 43:2159–2168
Robertson LJ (2009) Giardia and Cryptosporidium infections in sheep and goats: a review of the potential for transmission to humans via environmental contamination. Epidemiol Infect 137:913–921
Rosario K, Nilsson C, Lim YW, Ruan Y, Breitbart M (2009) Metagenomic analysis of viruses in reclaimed water. Environ Microbiol. doi:https://doi.org/10.1111/j.1462-2920.2009.01964.x
Rose JB, Epstein PR, Lipp EK, Sherman BH, Bernard SM, Patz JA (2001) Climate variability and change in the United States: potential impacts on water- and foodborne diseases caused by microbiologic agents. Environ Health Perspect 109:211–221
Rutjes SA, Lodder WJ, Lodder-Verschoor F, van den Berg HH, Vennema H, Duizer E, Koopmans M, de Roda Husman AM (2009) Sources of hepatitis E virus genotype 3 in The Netherlands. Emerg Infect Dis 15:381–387
Schijven JF, de Roda Husman AM (2005) Effect of climate changes on waterborne disease in The Netherlands. Water Sci Technol 51:79–87
Schwab KJ, Neill FH, Estes MK, Metcalf TG, Atmar RL (1998) Distribution of Norwalk virus within shellfish following bioaccumulation and subsequent depuration by detection using RT-PCR. J Food Prot 61:1674–1680
Singh RB, Hales S, de Wet N, Raj R, Hearnden M, Weinstein P (2001) The influence of climate variation and change on diarrheal disease in the Pacific Islands. Environ Health Perspect 109:155–159
Tang YZ, Dobbs FC (2007) Green autofluorescence in dinoflagellates, diatoms, and other microalgae and its implications for vital staining and morphological studies. Appl Environ Microbiol 73:2306–2313
Thomas V, Loret JF, Jousset M, Greub G (2008) Biodiversity of amoebae and amoebae-resisting bacteria in a drinking water treatment plant. Environ Microbiol 10:2728–2745
Toomey N, Monaghan A, Fanning S, Bolton D (2009) Transfer of antibiotic resistance marker genes between lactic acid bacteria in model rumen and plant environments. Appl Environ Microbiol 75:3146–3152
Victoria JG, Kapoor A, Li L, Blinkova O, Slikas B, Wang C, Naeem A, Zaidi S, Delwart E (2009) Metagenomic analyses of viruses in stool samples from children with acute flaccid paralysis. J Virol 83:4642–4651
WHO (2003) Emerging issues in water and infectious disease. World Health Organization, Geneva
WSAA (2008) WSAA report card 2007/2008. Performance of the Australian urban water industry and projections for the future. Water Services Association of Australia Ltd, Melbourne
Yang YJ, Goodrich JA (2009) Timing and prediction of climate change and hydrological impacts: periodicity in natural variations. Environ Geol 57:1065–1078
Zahid MS, Udden SM, Faruque AS, Calderwood SB, Mekalanos JJ, Faruque SM (2008) Effect of phage on the infectivity of Vibrio cholerae and emergence of genetic variants. Infect Immun 76:5266–5273
Zell R, Krumbholz A, Wutzler P (2008) Impact of global warming on viral diseases: what is the evidence? Curr Opin Biotechnol 19:652–660
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Ashbolt, N.J. (2010). Global Warming and Trans-Boundary Movement of Waterborne Microbial Pathogens. In: Sumi, A., Fukushi, K., Hiramatsu, A. (eds) Adaptation and Mitigation Strategies for Climate Change. Springer, Tokyo. https://doi.org/10.1007/978-4-431-99798-6_5
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DOI: https://doi.org/10.1007/978-4-431-99798-6_5
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