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Genome Duplication and Subfunction Partitioning: Sox9 in Medaka and Other Vertebrates

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Abstract

Teleost fish experienced a round of whole genome duplication (WGD) after their lineage segregated from the tetrapod lineage. The resulting duplicate genes underwent lineage-specific diversification, and in some cases, as in Sox9, both duplicates, sox9a and sox9b, persisted and partitioned ancestral regulatory and structural functions between them. Because mutations and genome rearrangements accumulate within a genome as lineages diverge, partitioning of gene subfunctions can differ in different species. Here, as a case study, we show partitioning of ancestral subfunctions between sox9a and sox9b in medaka, zebrafish, and other teleosts that highlights lineage-specific divergence of gene functions. These differences shed light on evolutionary mechanisms after genome duplication and emphasize general principles regarding gene orthologies when using animals with duplicated genomes as models for human disease.

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Acknowledgment

We thank the National Center for Research Resources (5R01RR020833) and National Institutes of Health (P01 HD22486) for support.

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Author notes

  1. Hayato Yokoi

    Present address: Institute of Neuroscience, University of Oregon, Eugene, OR, 97403, USA

Authors and Affiliations

  1. Graduate School of Agriculture, Tohoku University, Sendai, Miyagi, 981-8555, Japan

    John H. Postlethwait

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  1. Hayato Yokoi
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Correspondence to Hayato Yokoi .

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Editors and Affiliations

  1. Laboratory of Bioresources, National Institute for Basic Biology, 38 Nishigonaka, Myodaiji, Okazaki, Aichi, 444-8585, Japan

    Kiyoshi Naruse Ph.D. (Associate Professor) (Associate Professor)

  2. Laboratory of Molecular Genetics for Reproduction, National Institute for Basic Biology, 5-1 Higashiyama, Myodaiji, Okazaki, Aichi, 444-8787, Japan

    Minoru Tanaka Ph.D. (Associate Professor) (Associate Professor)

  3. Department of Biological Sciences Graduate School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan

    Hiroyuki Takeda Ph.D. (Professor) (Professor)

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© 2011 Springer

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Yokoi, H., Postlethwait, J.H. (2011). Genome Duplication and Subfunction Partitioning: Sox9 in Medaka and Other Vertebrates. In: Naruse, K., Tanaka, M., Takeda, H. (eds) Medaka. Springer, Tokyo. https://doi.org/10.1007/978-4-431-92691-7_21

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