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Airway Smooth Muscle Dysfunction in Asthma

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Book cover Allergy Frontiers: Classification and Pathomechanisms

Part of the book series: Allergy Frontiers ((ALLERGY,volume 2))

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Asthma is characterised by intermittent airflow obstruction with excessive bronchoconstriction and bronchial hyperresponsiveness (BHR). Since the airway smooth muscle (ASM) is the main contractile cell of the airways, it is clear that the ASM plays a major role in the genesis of these abnormalities. Airflow obstruction does not usually occur in non-asthmatics, thus one would presume that the ASM is abnormally contractile in asthma and there is now evidence that the abnormality of the contractile apparatus can be demonstrated in the asthmatic ASM itself. Therapies to relieve airflow obstruction promptly such as the inhalation of 2-adrenergic agonists are directly aimed at the ASM.

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Authors and Affiliations

  1. Airway Disease Section, National Heart and Lung Institute, Imperial College London, Dovehouse St, London, SW3 6LY, UK

    Maria B. Sukkar & Kian Fan Chung

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  1. Maria B. Sukkar
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  2. Kian Fan Chung
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Editors and Affiliations

  1. Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo, Japan

    Ruby Pawankar

  2. Southampton General Hospital, University of Southampton, Tremona Road, Southampton, UK

    Stephen T. Holgate

  3. Childrens's Mercy Hospital and Clinic, UMKC School of Medicine, 2401 Gillham Road, Kansas City, MO, 64108, USA

    Lanny J. Rosenwasser

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© 2009 Springer-Verlag Berlin Heidelberg

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Sukkar, M.B., Chung, K.F. (2009). Airway Smooth Muscle Dysfunction in Asthma. In: Pawankar, R., Holgate, S.T., Rosenwasser, L.J. (eds) Allergy Frontiers: Classification and Pathomechanisms. Allergy Frontiers, vol 2. Springer, Tokyo. https://doi.org/10.1007/978-4-431-88315-9_23

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  • DOI: https://doi.org/10.1007/978-4-431-88315-9_23

  • Publisher Name: Springer, Tokyo

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  • Online ISBN: 978-4-431-88315-9

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