Abstract
The Krüppel-like factor (KLF) family regulates several biological processes, such as self-renewal, proliferation, differentiation, development, and tissue-selectively restricted events of a cell at the transcriptional level. The KLF family has a highly conserved array of three C2H2-type zinc fingers with similarity to Drosophila Krüppel at the C-terminus, comprising a GC-rich DNA-binding domain, to mediate activation and/or repression of transcription. In contrast, the N-terminal regions of KLFs contain several distinct domains that are required for binding to chromatin-associated proteins, such as CtBP or Sin3A. We describe the structure—function aspects of KLFs, with a primary focus on the DNA-binding domains and the protein-binding domains.
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Nagashima, T., Hayashi, F., Umehara, T., Yokoyama, S. (2009). Molecular Structures of Krüppel-like Factors. In: Nagai, R., Friedman, S.L., Kasuga, M. (eds) The Biology of Krüppel-like Factors. Springer, Tokyo. https://doi.org/10.1007/978-4-431-87775-2_2
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DOI: https://doi.org/10.1007/978-4-431-87775-2_2
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