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Structure and Function of the Endothelial Cell Protein C Receptor

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Recent Advances in Thrombosis and Hemostasis 2008

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Abstract

The endothelial cell protein C receptor (EPCR) is a cell surface transmembrane glycoprotein and a novel member of the CD1/major histocompatibility complex class 1 superfamily. It was originally found to express specifically in endothelial cells, but recent studies demonstrated wide distribution of the molecule. EPCR is capable of high-affinity binding specific for protein C (PC) and activated protein C (APC). PC binding to EPCR results in acceleration of conversion to APC mediated by the thrombin/thrombomodulin complex, and it is required for regulation of blood coagulation. APC also binds to EPCR, and the APC-EPCR complex was found to promote activation of protease-activated receptor-1 (PAR-1). Binding to EPCR modulates the enzymatic specificity of APC and enables proteolysis of PAR-1, leading to intracellular signal transduction. The EPCR-APC-PAR-1 signaling induces various genes and explains the antiinflammatory, antiapoptotic, and wound healing effects of APC.

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Authors and Affiliations

  1. Department of Biomolecular Sciences, Division of Immunology, Saga Medical School, Room 2158, 5-1-1 Nabeshima, Saga, 849-8501, Japan

    Kenji Fukudome

Authors
  1. Kenji Fukudome
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Editor information

Editors and Affiliations

  1. Department of Pathology, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan

    Kenzo Tanaka M.D., Ph.D. (Professor Emeritus) (Professor Emeritus)

  2. Department of Biochemistry, University of Washington, J317 Health Science Center, Box 357350, Seattle, WA, 98195, USA

    Earl W. Davie Ph.D. (Professor) (Professor)

  3. School of Medicine, Internal Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan

    Yasuo Ikeda M.D., Ph.D. (Professor) (Professor)

  4. Department of Biology, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka, 812-8581, Japan

    Sadaaki Iwanaga Ph.D. (Professor Emeritus) (Professor Emeritus)

  5. Department of Medicine, Nagoya University, 26 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan

    Hidehiko Saito M.D., Ph.D. (Professor Emeritus) (Professor Emeritus)

  6. Pathophysiological and Experimental Division, Department of Pathology, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan

    Katsuo Sueishi M.D., Ph.D. (Professor) (Professor)

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Fukudome, K. (2008). Structure and Function of the Endothelial Cell Protein C Receptor. In: Tanaka, K., Davie, E.W., Ikeda, Y., Iwanaga, S., Saito, H., Sueishi, K. (eds) Recent Advances in Thrombosis and Hemostasis 2008. Springer, Tokyo. https://doi.org/10.1007/978-4-431-78847-8_13

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  • DOI: https://doi.org/10.1007/978-4-431-78847-8_13

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-78846-1

  • Online ISBN: 978-4-431-78847-8

  • eBook Packages: MedicineMedicine (R0)

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