Transition zone (TZ) cancer is commonly detected in transurethrally resected specimens but also radical prostatectomy specimens. According to a recent study, as many as 14% of stage T1c cancers are exclusively in the TZ. In general, they are small and are of low Gleason score (commonly <6). Because of their anatomic location (away from the “capsule”) and fewer penetrating nerves than in the peripheral zone, they are less likely to behave aggressively than those arising in non-TZs. As the volume increases, however, they may become more aggressive and can invade the anterior fibromuscular stroma, seminal vesicles, and pelvic lymph nodes. Microscopically, most transition zone carcinomas consist of well-differentiated glands of widely variable size and contour lined by tall columnar cells with clear cytoplasm.
- Benign Prostate Hyperplasia
- Seminal Vesicle
- Gleason Score
- Pelvic Lymph Node
- Radical Prostatectomy Specimen
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, access via your institution.
Tax calculation will be finalised at checkout
Purchases are for personal use onlyLearn about institutional subscriptions
Unable to display preview. Download preview PDF.
McNeal JE, Redwine EA, Freiha ES, Stamey TA (1988) Zonal distribution of prostate adenocarcinoma: correlation with histologic pattern and distribution of spread. Am J Surg Pathol 12:897–906.
McNeal JE (1992) Cancer volume and site of origin of adenocarcinoma in the prostate: relationship to local and distant spread. Hum Pathol 23:258–266.
Jack GS, Cookson MS, Coffey CS, Vader V, Roberts RL, Chang SS, Smith JA Jr, Shappell SB (2002) Pathological parameters of radial prostatectomy for clinical stages T1c versus T2 prostate adenocarcinoma: decreased pathological stage and increased detection of transition zone tumors. J Urol 168:519–524.
Greene DR, Egawa S, Neerhut G, Flanagan W, Wheeler TM, Scardino PT (1991) The distribution of residual cancer in radical prostatectomy specimens in stage A prostate cancer. J Urol 145:324–329.
Van de Voorde WM, Van Poppel HP, Verbeken EK, Oyen RH, Baert LV, Lauweryns JM (1995) Morphologic and neuroendocrine features of adenocarcinoma arising in the transition zone and in the peripheral zone of the prostate. Mod Pathol 8:591–598.
McNeal JE, Villers AA, Redwine RA, Freiha FS, Stamey TA (1990) Histologic differentiation, cancer volume, and pelvic lymph node metastasis in adenocarcinoma of the prostate. Cancer 66:1225–1233.
© 2008 Springer
About this chapter
Cite this chapter
(2008). What are the characteristics of transition zone cancer? Is it less aggressive than the non-transition-zone cancer?. In: Questions in Daily Urologic Practice. Springer, Tokyo. https://doi.org/10.1007/978-4-431-72819-1_6
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-72818-4
Online ISBN: 978-4-431-72819-1