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Protein and Polyamine Metabolism in Reversible Cerebral Ischemia of Gerbils

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Advances in Brain Resuscitation

Abstract

The interruption of blood flow to the brain induces disturbances of brain metabolism [1] which are not immediately reversed after restoration of cerebral blood flow. The timecourses of ischemia-induced disturbances do vary, however, for different biochemical events. The recovery of energy metabolism is a fast process following short-term cerebral ischemia and the content of high energy phosphates is rapidly replenished after the onset of recirculation [2]. Inhibition of protein biosynthesis, in contrast, persisted for hours or even days after ischemia. [3–9]. The consequences of prolonged disturbances in protein biosynthesis are not known; however, it is obvious that persistent inhibition of protein biosynthesis must effect the integrity of the cell as long as the degradation of proteins is not reduced to the same extent as the biosynthesis.

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Author information

Authors and Affiliations

  1. Department of Experimental Neurology, Max-Planck-Institute for Neurological Research, Gleneler Straße 50, 5000, Cologne 41, Federal Republic of Germany

    Konstantin-Alexander Hossmann

Authors
  1. Wulf Paschen
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  2. Yaxia Xie
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  3. Gabriele Röhn
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  4. Joachim Hallmayer
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  5. Konstantin-Alexander Hossmann
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Editor information

Editors and Affiliations

  1. Department of Anesthesiology and Critical Care Medicine, Yamaguchi University School of Medicine, 1144 Kogushi, Ube, Yamaguchi, 755, Japan

    Hiroshi Takeshita M.D. (Emeritus Professor) (Emeritus Professor)

  2. Laboratory for Experimental Brain Research, Head Research Departments, Lund Hospital, S-221 85, Lund, Sweden

    Bo K. Siesjö M.D. (Director) (Director)

  3. Department of Clinical Neurosciences, University of Edinburgh, Western General Hospital, EH4 2XU, Edinburgh, Scotland

    James Douglas Miller M.D. (Professor for Surgical Neurology and Chairman) (Professor for Surgical Neurology and Chairman)

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© 1991 Springer-Verlag Tokyo

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Paschen, W., Xie, Y., Röhn, G., Hallmayer, J., Hossmann, KA. (1991). Protein and Polyamine Metabolism in Reversible Cerebral Ischemia of Gerbils. In: Takeshita, H., Siesjö, B.K., Miller, J.D. (eds) Advances in Brain Resuscitation. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68538-8_6

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  • DOI: https://doi.org/10.1007/978-4-431-68538-8_6

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-68540-1

  • Online ISBN: 978-4-431-68538-8

  • eBook Packages: Springer Book Archive

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