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Joint Arthroplasty pp 76–84Cite as

Biological Role of Matrix Metalloproteinases and the Endogenous Inhibitor Proteins in the Periprosthetic Connective Tissue Remodeling Around Loose Artificial Hip Joints

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Summary

The biological role of extracellular matrix metalloproteinase (MMP) enzymes and their endogenous inhibitor proteins, tissue inhibitors of metalloproteinases (TIMPs), as a local host response, in the periprosthetic connective tissue remodeling around loose artificial hip joints was reviewed. In the periprosthetic granulomatous interface connective tissues between bone and implants and inner reactive cellular regenerating pseudocapsular tissues, MMP-1, MMP-2, MMP-3, MMP-9, and membrane type 1-MMP enzymes were at least well-shown in the light of immunohistochemistry, enzyme-activity analysis and protein-mRNA levels, when compared to outer fibrous capsular tissues and non-inflammatory synovial tissues. TIMP-1 and TIMP-2 were also continuously well-found in the corresponding tissues. Analysis of MMP-TIMP interaction shows that dominant MMPs cause imbalance between the enzymes and their endogenous inhibitor proteins, and also induces pathological periprosthetic connective tissue remodeling around total hip implants. The data suggest that an imbalanced MMP-TIMP system participates in the pathological extracellular matrix degradation and remodeling in the periprosthetic connective tissues, and relates to the biological local host response to the implants, thus contributing to implant loosening and periprosthetic osteolysis.

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Author information

Authors and Affiliations

  1. Department of Orthopaedic Surgery, Yamagata University School of Medicine, 2-2-2 Iida-nishi, Yamagata, 990-9585, Japan

    Michiaki Takagi, Hideo Ida, Iaso Takei & Toshihiko Ogino

  2. Department of Orthopaedics and Traumatology, Helsinki University Central Hospital, Topeliukusenkatu 5, Helsinki, FIN-00260, Finland

    Seppo Santavirta

  3. Department of Orthopaedics, Saiseikai Yamagata Hospital, Yamagata, 79-1, Okimachi, Yamagata, 990-8545, Japan

    Masaji Ishii

  4. Institute of Biomedicine, Department of Anatomy, University of Helsinki, PO Box 9 (Siltavuorenpenger 20A), Helsinki, FIN 00014, Finland

    Yrjö T. Konttinen

Authors
  1. Michiaki Takagi
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  2. Seppo Santavirta
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  3. Hideo Ida
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  4. Masaji Ishii
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  5. Iaso Takei
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  6. Toshihiko Ogino
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  7. Yrjö T. Konttinen
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Editor information

Editors and Affiliations

  1. Department of Orthopedic Surgery School of Medicine, Fukui Medical University, 23 Shimoaizuki, 910-1193, Matsuoka, Fukui, Japan

    Shinichi Imura M.D. (Professor and Chairman), Makoto Wada M.D. (Assistant Professor) & Hironori Omori M.D. (Assistant Professor) (Professor and Chairman),  (Assistant Professor) &  (Assistant Professor)

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© 1999 Springer-Verlag Tokyo

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Takagi, M. et al. (1999). Biological Role of Matrix Metalloproteinases and the Endogenous Inhibitor Proteins in the Periprosthetic Connective Tissue Remodeling Around Loose Artificial Hip Joints. In: Imura, S., Wada, M., Omori, H. (eds) Joint Arthroplasty. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68529-6_8

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  • DOI: https://doi.org/10.1007/978-4-431-68529-6_8

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-68531-9

  • Online ISBN: 978-4-431-68529-6

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