Skip to main content
SpringerLink
Log in

Delayed Neuronal Damage Following Focal Ischemic Injury in Stroke-Prone Spontaneously Hypertensive Rats

  • Conference paper
Neurochemical Monitoring in the Intensive Care Unit

  • 57 Accesses

Abstract

The striatum is highly vulnerable to ischemia. It also is innervated richly by both the corticostriatal glutamatergic pathway and nigrostriatal dopaminergic projections, which have been shown to interact with each other [1]. Excitatory amino acids, such as glutamate, may contribute to ischemic cell death by causing an intracellular overload of Ca2+ [2]. It has been suggested that dopamine contributes to ischemic cell death by producing oxygen radicals [3] or by potentiating the excitotoxic effects of glutamate [4].

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Cheramy A, Romo R, Godeheu G, Baruch P, Glowinski J (1986) In vivo presynaptic control of dopamine release in the cat caudate nucleus: II. Facilitatory or inhibitory influence of L-glutamate. Neuroscience 19: 1081–1090

    Article  PubMed  CAS  Google Scholar 

  2. Choi DW (1987) Ionic dependence of glutamate neurotoxicity. J Neurosci 7: 369–379

    PubMed  CAS  Google Scholar 

  3. Damsma G, Boisvert DP, Mudrick LA, Wenkstern D, Fibiger HC (1990) Effect of transient forebrain ischemia and pargyline on extracellular concentrations of dopamine, serotonin, and their metabolites in the rat striatum as determined by in vivo microdialysis. J Neurochem 54: 801–808

    Article  PubMed  CAS  Google Scholar 

  4. Globus MY-T, Busto R, Dietrich WD, Martinez E, Valdes I, Ginsberg MD (1988) Intra-ischemic extracellular release of dopamine and glutamate is associated with striatal vulnerability to ischemia. Neurosci Lett 91: 36–40

    Article  PubMed  CAS  Google Scholar 

  5. Coyle P (1982) Middle cerebral artery occlusion in the young rat. Stroke 13: 855–859

    Article  PubMed  CAS  Google Scholar 

  6. Coyle P, Jokelainen PT (1983) Differential outcome to middle cerebral artery occlusion in spontaneously hypertensive stroke-prone rats (SHRSP) and Wistar Kyoto (WKY) rats. Stroke 14: 605–611

    Article  PubMed  CAS  Google Scholar 

  7. Dienel GA (1984) Regional accumulation of calcium in postischemic rat brain. J Neurochem 43: 913–925

    Article  PubMed  CAS  Google Scholar 

  8. Shirotani T, Shima K, Iwata M, Kita H, Chigasaki H (1994) Calcium accumulation following middle cerebral artery occlusion in stroke-prone spontaneously hypertensive rats. J Cereb Blood Flow Metab 14: 831–836

    Article  PubMed  CAS  Google Scholar 

  9. Benveniste H, Huttemeier PC, Johansen FF, Diemer NH (1989) Calcium 45 accumulation in the dentate hilus: possible effect of NMDA receptors blockers. In: Hartmann A, Kuschinsky W (eds) Cerebral ischemia and calcium. Springer, Berlin Heidelberg, pp 266–273

    Google Scholar 

  10. Nagasawa H, Kogure K (1990) Exo-focal postischemic neuronal death in the rat brain. Brain Res 524: 196–202

    Article  PubMed  CAS  Google Scholar 

  11. Johnson RL, Koerner JF (1988) Excitatory amino acid neurotransmission. J Med Chem 31: 2057–2066

    Article  PubMed  CAS  Google Scholar 

  12. McGeorge AJ, Faull RLM (1989) The organization of the projection from the cerebral cortex to the striatum in the rat. Neuroscience 29: 503–537

    Article  PubMed  CAS  Google Scholar 

  13. Hassler R, Haug P, Nitsch C, Kim JS, Paik K (1982) Effect of motor and premotor cortex ablation on concentrations of amino acid, monoamines, and acetylcholine and on the ultrastructure in rat striatum. A confirmation of glutamate as the specific cortico-striatal transmitter. J Neurochem 38: 1087–1098

    Article  PubMed  CAS  Google Scholar 

  14. Perschak H, Cuenod M (1990) In vivo release of endogenous glutamate and aspartate in the rat striatum during stimulation of the cortex. Neuroscience 35: 283–287

    Article  PubMed  CAS  Google Scholar 

  15. Leviel V, Gobert A, Guibert B (1990) The glutamate-mediated release of dopamine in the rat striatum: further characterization of the dual excitatoryinhibitory function. Neuroscience 39: 305–312

    Article  PubMed  CAS  Google Scholar 

  16. Rothman SM, Olney JW (1987) Glutamate and the pathophysiology of hypoxicischemic brain damage. Ann Neurol 19: 105–111

    Article  Google Scholar 

  17. Choi DW, Maulucci-Gedde M, Kriegstein AR (1987) Glutamate neurotoxicity in cortical cell curture. J Neurosci 7: 357–368

    PubMed  CAS  Google Scholar 

  18. Nordborg C, Sokrab TEO, Johansson BB (1991) The relationship between plasma protein extravasation and remote tissue changes after experimental brain infarction. Acta Neuropathol (Bed) 82: 118–126

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Neurosurgery, National Defense Medical College, 3-2, Namiki, Tokorozawa, Saitama, 359, Japan

    Toshiki Shirotani, Katsuji Shima, Miwako Iwata, Hideyuki Kita & Hiroo Chigasaki

Authors
  1. Toshiki Shirotani
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Katsuji Shima
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Miwako Iwata
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Hideyuki Kita
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Hiroo Chigasaki
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Neurological Surgery, Nihon University School of Medicine, Tokyo, Japan

    Takashi Tsubokawa M.D., D.Sc. (Professor and Chairman) (Professor and Chairman)

  2. Division of Neurosurgery, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia, USA

    Anthony Marmarou Ph.D. (Professor) (Professor)

  3. Department of Neurosurgery, Baylor College of Medicine, Houston, Texas, USA

    Claudia Robertson M.D. (Professor) (Professor)

  4. Department of Neurosurgery, Southern General Hospital, University of Glasgow, Glasgow, Scotland, UK

    Graham Teasdale M.D. (Professor and Chairman) (Professor and Chairman)

Rights and permissions

Reprints and permissions

Copyright information

© 1995 Springer-Verlag Tokyo

About this paper

Cite this paper

Shirotani, T., Shima, K., Iwata, M., Kita, H., Chigasaki, H. (1995). Delayed Neuronal Damage Following Focal Ischemic Injury in Stroke-Prone Spontaneously Hypertensive Rats. In: Tsubokawa, T., Marmarou, A., Robertson, C., Teasdale, G. (eds) Neurochemical Monitoring in the Intensive Care Unit. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68522-7_3

Download citation

  • DOI: https://doi.org/10.1007/978-4-431-68522-7_3

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-68524-1

  • Online ISBN: 978-4-431-68522-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation