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Adoptive Immunotherapy of Human Diseases with Antigen-Specific T-Cell Clones

  • Conference paper
Cell Therapy

Part of the book series: Keio University Symposia for Life Science and Medicine ((KEIO,volume 5))

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Summary

Cellular adoptive immunotherapy refers to the transfer of effector cells of the immune system to treat infectious or malignant diseases. Our laboratory has been investigating the use of adoptive immunotherapy with antigen-specific T-cell clones to prevent cytomegalovirus (CMV) infection in allogeneic bone marrow transplant (BMT) recipients; augment immune responses to human immunodeficiency virus (HIV) in HIV-seropositive individuals; and to induce a graft-versus-leukemia (GVL) response in allogeneic BMT recipients. In each of these settings the rationale for developing adoptive immunotherapy is based on clear evidence that deficiencies of antigen-specific T cells are responsible for disease progression. Functional studies of effector activity and genetic markers have been used to demonstrate that adoptively transferred T-cell clones can persist and function in the host and migrate appropriately to sites of disease. It is anticipated that additional studies will define disease settings in which T-cell therapy can be beneficial and further elucidate the requirements for effective immunotherapy in humans.

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Author information

Authors and Affiliations

  1. Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA, 98109, USA

    Stanley R. Riddell, Edus H. Warren, Deborah Lewinsohn, Rici De Fries, Lawrence Corey & Philip D. Greenberg

  2. Department of Medicine, University of Washington, Seattle, WA, 98104, USA

    Stanley R. Riddell, Scott Brodie, Lawrence Corey & Philip D. Greenberg

Authors
  1. Stanley R. Riddell
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  2. Edus H. Warren
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  3. Deborah Lewinsohn
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  4. Scott Brodie
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  5. Rici De Fries
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  6. Lawrence Corey
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  7. Philip D. Greenberg
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Editor information

Editors and Affiliations

  1. Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, 160-8582, Shinjuku-ku, Tokyo, Japan

    Yasuo Ikeda M.D., Dr. Med. Sci. (Professor) & Yutaka Hattori M.D., Dr. Med. Sci. (Professor) & 

  2. Department of Pathology, Keio University School of Medicine, 35 Shinanomachi, 160-8582, Shinjuku-ku, Tokyo, Japan

    Jun-ichi Hata M.D., Dr. Med. Sci. (Professor) (Professor)

  3. Department of Microbiology, Keio University School of Medicine, 35 Shinanomachi, 160-8582, Shinjuku-ku, Tokyo, Japan

    Shigeo Koyasu Ph.D. (Professor) (Professor)

  4. Institute for Advanced Medical Research, Keio University School of Medicine, 35 Shinanomachi, 160-8582, Shinjuku-ku, Tokyo, Japan

    Yutaka Kawakami M.D., Dr. Med. Sci. (Professor) (Professor)

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© 2000 Springer-Verlag Tokyo

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Riddell, S.R. et al. (2000). Adoptive Immunotherapy of Human Diseases with Antigen-Specific T-Cell Clones. In: Ikeda, Y., Hata, Ji., Koyasu, S., Kawakami, Y., Hattori, Y. (eds) Cell Therapy. Keio University Symposia for Life Science and Medicine, vol 5. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68506-7_3

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  • DOI: https://doi.org/10.1007/978-4-431-68506-7_3

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-68508-1

  • Online ISBN: 978-4-431-68506-7

  • eBook Packages: Springer Book Archive

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