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Development of Quantitative Magnetic Resonance Imaging for Assessment of Cartilage Damage and Repair in Vivo

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Advances in Osteoarthritis

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Summary

This chapter describes the computerized analysis of quantitative magnetic resonance (MR) parameters of water protons within articular cartilage. Those parameters were found to be consistently within a defined range for normal healthy cartilage and altered in a reproducible manner when the cartilage was fibrillated or the matrix degraded. T1 and T2 relaxation rates and magnetization transfer characteristics (T1sat and Msat/M0) of water in distal interphalangeal (DIP) joints were analyzed from a set of MR images acquired in vivo with a total scan time of 35 min, slice thickness of 1.5 mm, and resolution of 150µm2. A significant two- to threefold increase in the T2 and Msat/M0 ratio was found in DIP cartilage from asymptomatic volunteers compared to patients with nodal osteoarthritis. A similar increase was identified in 3-mm-diameter, full-depth biopsy samples from osteoarthritic (OA) femoral cartilage representative of different stages in cartilage degeneration compared to values obtained from processing images of the knee of normal volunteers with a slice thickness of 2 mm and resolution of 600µm2. This technology therefore provides an objective and quantitative means of identifying and monitoring cartilage degradation and repair within joints in vivo.

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Author information

Authors and Affiliations

  1. Strangeways Research Laboratory, Worts’ Causeway, Cambridge, CB1 4RN, UK

    Jenny A. Tyler

  2. Herchel Smith Laboratory for Medicinal Chemistry, Cambridge University School of Clinical Medicine, University Forvie Site, Robinson Way, Cambridge, CB2 2PZ, UK

    Laurance D. Hall & Paul J. Watson

Authors
  1. Jenny A. Tyler
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  2. Laurance D. Hall
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  3. Paul J. Watson
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Editor information

Editors and Affiliations

  1. Kinki University School of Medicine, 377-2 Ohno-Higashi, Osaka-Sayama, 589-8511, Osaka, Japan

    Seisuke Tanaka M.D. (Dean) (Dean)

  2. Department of Orthopedic Surgery, Kinki University School of Medicine, 377-2 Ohno-Higashi, Osaka-Sayama, 589-8511, Osaka, Japan

    Chiaki Hamanishi M.D. (Professor) (Professor)

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© 1999 Springer-Verlag Tokyo

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Tyler, J.A., Hall, L.D., Watson, P.J. (1999). Development of Quantitative Magnetic Resonance Imaging for Assessment of Cartilage Damage and Repair in Vivo. In: Tanaka, S., Hamanishi, C. (eds) Advances in Osteoarthritis. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68497-8_7

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  • DOI: https://doi.org/10.1007/978-4-431-68497-8_7

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-68499-2

  • Online ISBN: 978-4-431-68497-8

  • eBook Packages: Springer Book Archive

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