Summary
Regulation of intracellular pH and cell volume is essential for the normal function of a cell. The Na+/H+ exchanger in the plasma membrane plays a major role in both functions by extruding cytoplasmic H+ in exchange for extracellular Na+. In cardiomyocytes, in which protons are continuously produced by high metabolic activity, elucidation of the regulatory mechanism of the Na+/H+ exchanger is particularly important, because intracellular pH is a key modulator of contractility and because the transporter plays a critical role in cardiac pathophysiology such as ischemia/reperfusion-associated cell injury. In these cells, the ubiquitous form (NHE1) of the transporter is predominantly expressed and its activity presumably is under the regulatory influence of a variety of extracellular and intracellular factors including many receptor agonists, osmotic stress, and cell ATP level, as in other cell types. Recent advances in the molecular mechanism of short-term regulation of NHE1 by these factors and its pathophysiological relevance are discussed in this chapter.
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© 1998 Springer-Verlag Tokyo
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Shigekawa, M., Ikeda, T., Iwamoto, T., Wakabayashi, S. (1998). Regulatory Mechanism of NHE1 Isoform of Na+/H+ Exchanger in Cardiac and Other Tissues. In: Abiko, Y., Karmazyn, M. (eds) Protection Against Ischemia/Reperfusion Damage of the Heart. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68482-4_1
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DOI: https://doi.org/10.1007/978-4-431-68482-4_1
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