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Protection Against Ischemia/Reperfusion Damage of the Heart pp 3–21Cite as

Regulatory Mechanism of NHE1 Isoform of Na+/H+ Exchanger in Cardiac and Other Tissues

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Summary

Regulation of intracellular pH and cell volume is essential for the normal function of a cell. The Na+/H+ exchanger in the plasma membrane plays a major role in both functions by extruding cytoplasmic H+ in exchange for extracellular Na+. In cardiomyocytes, in which protons are continuously produced by high metabolic activity, elucidation of the regulatory mechanism of the Na+/H+ exchanger is particularly important, because intracellular pH is a key modulator of contractility and because the transporter plays a critical role in cardiac pathophysiology such as ischemia/reperfusion-associated cell injury. In these cells, the ubiquitous form (NHE1) of the transporter is predominantly expressed and its activity presumably is under the regulatory influence of a variety of extracellular and intracellular factors including many receptor agonists, osmotic stress, and cell ATP level, as in other cell types. Recent advances in the molecular mechanism of short-term regulation of NHE1 by these factors and its pathophysiological relevance are discussed in this chapter.

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Authors and Affiliations

  1. Department of Molecular Physiology, National Cardiovascular Center Research Institute, Fujishiro-dai 5-7, Suita, Osaka, 565-0873, Japan

    Munekazu Shigekawa, Toshitaro Ikeda, Takahiro Iwamoto & Shigeo Wakabayashi

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  1. Munekazu Shigekawa
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  2. Toshitaro Ikeda
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  3. Takahiro Iwamoto
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  4. Shigeo Wakabayashi
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Editors and Affiliations

  1. Department of Pharmacology, Asahikawa Medical College, Nishikagura 4-5, 3-11, Asahikawa, 078-8510, Japan

    Yasushi Abiko MD (Professor) (Professor)

  2. Department of Pharmacology and Toxicology, The University of Western Ontario, Medical Sciences Building, London, Ontario, Canada, N6A 5C1

    Morris Karmazyn PhD (Professor and Career Investigator of the Heart and Stroke Foundation of Ontario) (Professor and Career Investigator of the Heart and Stroke Foundation of Ontario)

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© 1998 Springer-Verlag Tokyo

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Shigekawa, M., Ikeda, T., Iwamoto, T., Wakabayashi, S. (1998). Regulatory Mechanism of NHE1 Isoform of Na+/H+ Exchanger in Cardiac and Other Tissues. In: Abiko, Y., Karmazyn, M. (eds) Protection Against Ischemia/Reperfusion Damage of the Heart. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68482-4_1

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  • DOI: https://doi.org/10.1007/978-4-431-68482-4_1

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-68484-8

  • Online ISBN: 978-4-431-68482-4

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