Abstract
The results of recent experimental studies using animal models have greatly increased our knowledge of the early biochemical, pathophysiological, and histological events in ischemic brain tissue damage [1–7]. To improve the clinical results of early intervention in acute stroke patients, it is important that clinical practice respond to the implications of the results obtained in experimental studies [8,9]. Positron emission tomography (PET) of the brain provides quantitative maps of regional cerebral blood flow, oxygen metabolism, and blood volume. Although PET has some limitations, it may provide a bridge between experimental studies and clinical practice. In this symposium, we present our experiences with PET studies in patients with cerebral embolism in the very acute phase and discuss indication for reperfusion treatment.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Astrup J. Siesjö BK, Symon L (1981) Thresholds in cerebral ischemia-the ischemic penumbra. Stroke 12: 723–725
Reicle ME (1983) The pathophysiology of brain ischemia. Ann Neurol 13: 2–10
Heiss W-D, Rosner G (1983) Functional recovery of cortical neurons as related to degree and duration of ischemia. Ann Neurol 14: 294–301
Heiss W-D (1992) Experimental evidence for ischemic thresholds and functional recovery. Stroke 23: 1668–1672
Hossman KA (1988) Pathophysiology of cerebral infarction. In: Vinken PJ, Bruyn GW, Klawans HL, Tool JF (eds) Handbook of clinical neurology, vol 53. Elsevier, New York, pp 107–153
Siejö BK (1984) Cerebral circulation and metabolism. J Neurosurg 60: 883–908
Garcia JH (1993) Pathophysiology of ischemic injury of the brain. In: Nelson JS, Parisi JE, Schochet SS Jr (eds) Principles and practice of neuropathology. Mosby, St Louis, pp 459–469
Heiss W-D, Huber M, Fink GR, Herholz K, Pietrzyk U, Wagner R, Wienhard K (1992) Progressive derangement of periinfarct viable tissue in ischemic stroke. J Cereb Blood Flow Metab 12: 193–203
Powers WJ (1993) The ischemic penumbra; usefulness of PET. In: del Zoppo GJ, Mori E, Hacke W (eds) Thrombolytic therapy in acute ischemic stroke II. Springer, Berlin, Heidelberg, pp 17–21
Higano S, Uemura K, Shishido H, Kanno I, Tomura N, Sakamoto K (1993) Evaluation of critically perfused area in acute ischemic stroke for therapeutic reperfusion: a clinical PET study. Ann Nucl Med 7: 167–171
Kanno I, Miura S, Yamamoto S, Uemura K (1985) Design and evaluation of a positron emission tomograph, HEADTOME IV. J Comput Assist Tomogr 9: 931–938
Sundt T Jr, Sharbough FW, Anderson RE, Michenfelder JD (1974) Cerebral blood flow measurement and electroencephalogram during carotid endarterectomy. J Neurosurg 41: 310–320
Baron JC, Rougemout D, Bousser MG, Lebrum-Gardie P, Iba-Zizen MT, Chivas JC (1981) Local CBF oxygen extraction fraction and CMRO,; Prognostic values in recent supratentorial infarction. J Cereb Blood Flow Metab 3 (suppl 1): S1–S2
Hakim AM, Evans AC, Berger I, Kuwabara H, Worsley K, Marchal G, Beil C, Pokrupa R, Diksic M, Meyer E, Gjedde A, Marret S (1989) The effect of nimodipine on the evaluation of human cerebral infarction studied by PET. J Cereb Blood Flow Metab 9: 523–534
Powers WJ, Grubb RL, Darriet D, Reicle ME (1985) Cerebral blood flow and cerebral metabolic rate of oxygen requirements for cerebral function and viability in humans. J Cereb Blood Flow Metab 5: 600–608
del Zoppo GJ (1994) Microvascular changes during cerebral ischemia and reperfusion. Cerebrovasc Brain Metab Rev 6: 47–96
Minematsu K, Yamaguchi T, Omae T (1992) “Spectacular shrinking deficit”: rapid recovery from a major hemispheric syndrome by migration of an embolus. Neurology 42: 596–162
del Zoppo GJ, Copeland RB, Andercheck K, Hacke W, Koziol JA (1990) Hemorrhagic transformation following tissue plasminogen activator in experimental cerebral infarction. Stroke 21: 596–601
Heiss W-D, Podreka I (1993) Role of PET and SPECT in the assessment of ischemic cerebrovascular disease. Cerebrovasc Brain Metab Rev 5: 235–263
Iida H, Itoh H, Bloomfield PM, Munaka M, Higano S, Murakami M, Inugami A, Ebri S, Aizawa Y, Kanno I, Uemura K (1994) A method to quantitate cerebral blood flow using a rotating gamma camera and iodine-123 amphetamine with one blood sampling. Eur J Nucl Med 21: 1072–1084
Abi-Dargham A, Lauruelle M, Seibyl J (1994) SPECT measurement of benzodiazepine receptor binding in human brain with iodine-123-lomazenil: kinetic and equilibrium paradigms. J Nucl Med 35: 228–238
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1995 Springer-Verlag Tokyo
About this paper
Cite this paper
Uemura, K., Higano, S. (1995). Positron Emission Tomography in Patients with an Acute Embolic Occlusion of the Carotid Artery. In: Yamaguchi, T., Mori, E., Minematsu, K., del Zoppo, G.J. (eds) Thrombolytic Therapy in Acute Ischemic Stroke III. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68459-6_4
Download citation
DOI: https://doi.org/10.1007/978-4-431-68459-6_4
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-70139-2
Online ISBN: 978-4-431-68459-6
eBook Packages: Springer Book Archive