Abstract
Symptomatic intracerebral hemorrhage is an often-feared companion of acute cerebral ischemia treated with plasminogen activators. The pathophysiology of parenchymal hemorrhage is poorly understood and has been the subject of previous treatises in this series [1,2]. Clinical studies of this disorder suggest a spectrum of clinical severity from asymptomatic episodes diagnosed by computed tomographic (CT) scan or magnetic resonance imaging (MRI) to catastrophic events with debilitating or fatal issue [3–13]. The importance of understanding the pathogenesis of hemorrhagic events, particularly in the setting of fibrinolytic intervention, is emphasized by the dilemma that can arise in judging whether a particular hemorrhage may be reasonably attributable to the plasminogen activator the patient has received.
Keywords
- Acute Ischemic Stroke
- Focal Cerebral Ischemia
- Hemorrhagic Transformation
- Embolic Stroke
- Hemorrhagic Event
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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del Zoppo, G.J., Okada, Y., Hamann, G.F., Fitridge, R., Pessin, M.S. (1995). Mechanisms of Fibrinolysis-Associated Hemorrhagic Transformation. In: Yamaguchi, T., Mori, E., Minematsu, K., del Zoppo, G.J. (eds) Thrombolytic Therapy in Acute Ischemic Stroke III. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68459-6_30
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