Abstract
Mbl bipolar cell, which is a subclass of bipolar cells in the goldfish retina, dominantly receives inputs from rods [1], and responds to a spot of light with depolarization (ON-type) [2]. Recently, Mbl bipolar cell has been shown to generate spontaneous calcium transients [3], and is capable of light-evoked calcium spike [4]. The spikes would be generated by ionic currents in their axon terminal (AT) [3, 4]. It is essential to analyze the mechanisms using a modeling simulation in order to understand how the ionic current of the cell plays a role in shaping the light responses. In this study, we analyzed the contribution of ionic mechanisms to light responses of Mbl bipolar cell using a mathematical model based on ionic currents.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Ishida AT, Stell WK, Lightfoot DO (1980) Rod and cone inputs to bipolar cells in goldfish retina. J Comp Neurol 1991: 315–335
Saito T, Kondo H, Toyoda J (1979) Ionic mechanisms of two types of on-center bipolar cells in the carp retina. J Gen Physiol 73: 73–90
Zenisek D, Matthews G (1998) Calcium action potentials in retinal bipolar neurons. Vis Neurosci 15: 69–75
Protti DA, Flores-Herr N, Gersdorff H (2000) Light evokes Ca’ spikes in the axon terminal of a retinal bipolar cell. Neuron 25: 215–227
Ishihara A, Kamiyama Y, Usui S (1998) Analysis of light responses at the retinal bipolar cells based on ionic current model. In: Bower J (ed) Computational neuroscience: trends in research. Plenum Press, New York, 203–209
Usui S, Ishihara A, Kamiyama Y, et al. (1996) Ionic current model of bipolar cells in the lower vertebrate retina. Vision Res 36: 4069–4076
Hodgkin AL, Huxley AF (1952) A quantitative description of membrane current and its application to conduction and excitation in nerve. J Physiol 117: 500–544
Kamiyama Y, Ogura T, Usui S (1996) Ionic current model of the vertebrate rod photoreceptor. Vision Res 36: 4059–4068
Kobayashi K, Tachibana M (1995) Ca2+ regulation in the presynaptic terminals of goldfish retinal bipolar cells. J Physiol 483: 79–94
Tachibana M, Okada T, Arimura T, et al. (1993) Dihydropyridine-sensitive calcium current mediates neurotransmitter release from bipolar cells of the goldfish retina. J Neurosci 13: 2898–2909
Okada T, Horiguchi H, Tachibana M (1995) Ca2+-dependent Cl-current at the presynaptic terminals of goldfish retinal bipolar cells. Neurosci Res 23: 297–303
Sakaba T, Ishikane H, Tachibana M (1997) Ca2+ activated K+ current at presynaptic terminals of goldfish retinal bipolar cells. Neurosci Res 27: 219–228
von Gersdorff H, Matthews G (1996) Calcium-dependent inactivation of calcium current in synaptic terminals of retinal bipolar neurons. J Neurosci 16: 115–122
Mennerick S, Zenisek D, Matthews G (1997) Static and dynamic membrane properties of large-terminal bipolar cells from goldfish retina: experimental test of a compartment model. J Neurophysiol 78: 51–62
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2003 Springer-Verlag Tokyo
About this paper
Cite this paper
Ishihara, A., Kamiyama, Y., Usui, S. (2003). The Role of Ionic Currents in Shaping Light Responses of Retinal Bipolar Cell. In: Kaneko, A. (eds) The Neural Basis of Early Vision. Keio University International Symposia for Life Sciences and Medicine, vol 11. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68447-3_44
Download citation
DOI: https://doi.org/10.1007/978-4-431-68447-3_44
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-68449-7
Online ISBN: 978-4-431-68447-3
eBook Packages: Springer Book Archive