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Neurite outgrowth-promoting prostaglandins that act as neuroprotective agents against brain ischemia and may enhance recovery of higher neuronal functions

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Strategic Medical Science Against Brain Attack

Summary

A large number of compounds have been reported to prevent ischemia-induced neuronal death, whereas there are few described to enhance recovery of brain functions. Since neurotrophins do not only prevent neuronal death but also protect neuronal circuits, they may be potential candidates. However, their poor penetration of the blood-brain-barrier hampers their development as therapeutic agents. In this context, low-molecular-weight compounds that possess neurite outgrowth- and neuronal survival-promoting activities may be alternative candidates. Neurite outgrowth-promoting prostaglandins, which were recently-synthesized based on the chemical structure of anti-tumor cyclopentenone prostaglandin derivatives, have been characterized by their neurotrophic effects on neurons in the central nervous system. In this paper, we present a review of these compounds as therapeutic agents against brain ischemia.

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Authors and Affiliations

  1. Department of Welfare Engineering, Faculty of Engineering, Iwate University, 4-3-5 Ueda, Morioka, Iwate, 020-8551, Japan

    Takumi Satoh & Ryuzo Shingai

  2. Department of Biomolecular Science, Faculty of Engineering, Gifu University, Gifu, 501-1193, Japan

    Kyoji Furuta & Masaaki Suzuki

  3. Department of Physiology, Graduate School of Medicine, Osaka City University, Osaka, 545-8585, Japan

    Yasuyoshi Watanabe

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  1. Takumi Satoh
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  2. Ryuzo Shingai
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  3. Kyoji Furuta
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  4. Masaaki Suzuki
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  5. Yasuyoshi Watanabe
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Editors and Affiliations

  1. National Cardio-Vascular Center, 5-7-1 Fujishiro-dai, Suita, Osaka, 565-8565, Japan

    Haruhiko Kikuchi (President Emeritus) (President Emeritus)

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© 2002 Springer-Verlag Tokyo

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Satoh, T., Shingai, R., Furuta, K., Suzuki, M., Watanabe, Y. (2002). Neurite outgrowth-promoting prostaglandins that act as neuroprotective agents against brain ischemia and may enhance recovery of higher neuronal functions. In: Kikuchi, H. (eds) Strategic Medical Science Against Brain Attack. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68430-5_6

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  • DOI: https://doi.org/10.1007/978-4-431-68430-5_6

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-68432-9

  • Online ISBN: 978-4-431-68430-5

  • eBook Packages: Springer Book Archive

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