Abstract
This paper reviews some recent theoretical models of endothelial cell junctions and transport of fluid through the clefts. The classical system of small and large pores is replaced by a system of slits. It is postulated that the uniform spacing of 200 A is maintained by macromolecules which bridge between two cell membranes. Such bridging molecules could maintain the observed cell spacing without causing a major increase in flow resistance. The molecular forces at tight junctions account for the bending of cell membranes and discontinuities in the tight junctions leave tortuous pathways allowing passage of solutes up to the size of albumin.
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© 1988 Springer-Verlag Tokyo
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Skalak, R. (1988). Models of Endothelial Cell Junctions. In: Yoshida, Y., Yamaguchi, T., Caro, C.G., Glagov, S., Nerem, R.M. (eds) Role of Blood Flow in Atherogenesis. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68399-5_40
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DOI: https://doi.org/10.1007/978-4-431-68399-5_40
Publisher Name: Springer, Tokyo
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