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Role of Blood Flow in Atherogenesis pp 163–169Cite as

Morphological Changes in the Flow Loaded Canine Carotid Artery

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Abstract

Morphological changes in the flow loaded canine carotid artery were studied using arterio-venous shunts. First (1 to 3 days) endothelial cells swelled. Then (7 days) they were activated with increased cytoplasmic microfilaments and thickening of the basement membrane. After 2 to 4 weeks, they proliferated with splitting and multiplication of the internal elastic lamina. In 6 to 12 months, reconstruction of the arterial wall was complete with an increase of medial elastic fibers and medial laminae. This sequence of changes in flow loaded artery may be important in considering the role of blood flow in atherogenesis.

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Author information

Authors and Affiliations

  1. Second Department of Pathology, Akita University School of Medicine, Akita, 010, Japan

    H. Masuda, K. Kawamura, K. Tohda & T. Shozawa

Authors
  1. H. Masuda
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  2. K. Kawamura
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  3. K. Tohda
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  4. T. Shozawa
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Editor information

Editors and Affiliations

  1. Department of Pathology, Yamanashi Medical College, Tamaho, 409-38, Japan

    Yoji Yoshida

  2. Department of Vascular Physiology, National Cardiovascular Center Research Institute, Suita, 565, Japan

    Takami Yamaguchi

  3. Physiological Flow Studies Unit, Imperial College, London, SW7 2AZ, England

    Colin G. Caro

  4. Department of Pathology, University of Chicago, Chicago, IL, 60637, USA

    Seymour Glagov

  5. Biomechanics Laboratory and School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA, 30332-0405, USA

    Robert M. Nerem

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© 1988 Springer-Verlag Tokyo

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Cite this paper

Masuda, H., Kawamura, K., Tohda, K., Shozawa, T. (1988). Morphological Changes in the Flow Loaded Canine Carotid Artery. In: Yoshida, Y., Yamaguchi, T., Caro, C.G., Glagov, S., Nerem, R.M. (eds) Role of Blood Flow in Atherogenesis. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68399-5_24

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  • DOI: https://doi.org/10.1007/978-4-431-68399-5_24

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-68401-5

  • Online ISBN: 978-4-431-68399-5

  • eBook Packages: Springer Book Archive

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