Abstract
Portal hypertension, like systemic arterial hypertension, may be clinically latent and is usually diagnosed under three circumstances. First, in patients with chronic liver disease, clinical evaluation, ultrasound, and endoscopic studies are performed to evaluate the presence and consequences of portal hypertension. Second, portal hypertension may be discovered during esophageal endoscopy, disclosing esophageal varices, or during abdominal ultrasound, showing splenomegaly and portal-systemic collaterals. Third, portal hypertension is often discovered due to its complications, usually ascites or an episode of gastrointestinal bleeding, but rarely hepatic encephalopathy. Less frequent complications are hypoxia, pulmonary arterial hypertension, arterial aneurysms, and alterations in drug disposition (Table 19.1.)
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Westaby S, Wilkinson S, Williams R (1978) Spleen size and portal hypertension in cirrhosis. Digestion 17: 63
Kitani K, Luchi M (1990) Schistosomiasis japonica: A vanishing endemic in Japan. J Gastroenterol Hepatol 5: 160–172
Yamamoto S, Yokoyama Y, Takashige K, lwatsuki S (1968) Budd-Chiari syndrome with obstruction of the inferior vena cava. Gastroenterology 54: 1070–1084
Lebrec D, Benhamou J-P (1985) Ectopic varices in portal hypertension. J Clin Gastroenterol 14: 105–121
Hosking SW, Johnson AG, Smart HL, Triger DR (1989) Anorectal varices, haemorrhoids, and portal hypertension. Lancet i: 349–352
Doyle FH, Read AE, Evans KT (1961) The mediastinum in portal hypertension. Clin Radio 12: 114–129
Castellino RA, Blank N, Adams FA (1972) Dilated azygos and hemiazygos veins presenting as paravertebral intrathoracic masses. N Engl J Med 278: 1087–1091
Moult PJA, Waite DW, Dick R (1975) Posterior mediastinal venous masses in patients with portal hypertension. Gut 16: 57–61
Takayasu K, Kobayashi C, Takashi M, Okuda K (1982) Paraesophageal varices mimicking a mediastinal tumor. J Clin Gastroenterol 4: 163–166
Guivarch P, Buffet C, Roche A, Cauquil P, Etienne JP (1987) Pseudotumeurs mediastinales au cours de la cirrhose. Intérêt diagnostique de la résonance magnétique nucléaire dans 3 cas. Gastroenterol Clin Biol 11: 333–337
Calès P, Braillon A, Jiron MI, Lebrec D (1984) Superior portosystemic collateral circulation estimated by azygos blood flow in patients with cirrhosis. Lack of correlation with oesophageal varices and gastrointestinal bleeding. Effect of propranolol. J Hepatol 1: 37–46
Grendell JH, Ockner RK (1982) Mesenteric venous thrombosis. Gastroenterology 82: 358–372
Boyer TD, Zia P, Reynolds TB (1979) Effect of indomethacin and prostaglandin A1 on renal function and plasma renin activity in alcoholic liver disease. Gastroenterology 77: 215–222
Verbanck JJ, Rutgeerts LJ, Haerens MH, Tytgat HJ, Afschrift MB (1984) Partial splenoportal and superior mesenteric venous thrombosis. Gastroenterology 86: 949–952
Warshaw AL, Jin G, Ottinger LW (1987) Recognition and clinical implications of mesenteric and portal vein obstruction in chronic pancreatitis. Arch Surg 122: 410–415
Rice RP, Thompson WM, Kelvin FM, Kriner AF, Garbutt JT (1977) Gastric varices without esophageal varices. An important preendoscopic diagnosis. JAMA 237: 1976–1979
Carr N, Jamison MH (1981) Superior mesenteric thrombosis. Br J Surg 68: 343–344
Bradley III EL (1987) The natural history of splenic vein thrombosis due to chronic pancreatitis: Indications for surgery. Int J Pancreatol 2: 87–92
Mikaki CT, Park YS, Gopalswamy N (1988) Upper gastrointestinal bledding in acute mesenteric thrombosis. J Clin Gastroenterol 10: 84–87
Bihari D, Gimson AES, Waterson M, Williams R (1985) Tissue hypoxia during fulminant hepatic failure. Crit Care Med 13: 1034–1039
Braillon A, Moreau R, Hadengue A, Roulot D, Sayegh R, Lebrec D (1989) Hyperkinetic circulatory syndrome in patients with presinusoidal portal hypertension: Effect of propranolol. J Hepatol 9: 312–318
Arroyo V, Bernardi M, Epstein M, Henriksen JH, Schrier RW, Rodes J (1988) Pathophysiology of ascites and functional renal failure in cirrhosis. J Hepatol 6: 239–257
Akriviadis EA, Runyon BA (1990) Utility of an algorithm in differentiating spontaneous from secondary bacterial peritonitis. Gastroenterology 98: 127–133
Albillos A, Cuervas-Mons V, Millan I, Canton T, Montes J, Barrios C, Garrido A, Escartin P (1990) Ascitic fluid polymorphonuclear cell count and serum to ascites albumin gradient in the diagnosis of bacterial peritonitis. Gastroenterology 98: 132–140
Lindsay JW, Sherlock S (1979) The aetiology, presentation and natural history of extra-hepatic portal venous obstruction. Q J Med 192: 627–639
Valla D, Flejou JF, Lebrec D, Bernuau J, Rueff B, Salzmann JL, Benhamou JP (1989) Portal hypertension and ascites in acute hepatitis: Clinical, hemodynamic and histological correlations. Hepatology 10: 482–487
Rubinstein D, Mclnnes I, Dudley F (1985) Hepatic hydrothorax in the absence of clinical ascites: diagnosis and management. Gastroenterology 88: 188–191
Hoefs JC (1990) Diagnostic paracentesis. A potent clinical tool. Gastroenterology 98: 230–236
Rector WG (1987) An improved diagnostic approach to ascites. Arch Intern Med 147: 215
Beppu K, Inokushi K, Koyanaga N, Nakayama S, Sakata H, Kitano S, Kobayashi M (1981) Prediction of variceal hemorrhage by esophageal endoscopy. Gastrointest Endosc 27: 213–218
Sutton FM (1987) Upper gastrointestinal bleeding in patients with esophageal varices. What is the most common source?. Am J Med 83: 273–275
The Italian Liver Cirrhosis Project (1987) Reliability of endoscopy in the assessment of variceal features. J Hepatol 4: 93–98
Cales P, Pascal JP (1988) Histoire naturelle des varices oesophagiennes au cours de la cirrhose (de la naissance à la rupture) Gastroenterol Clin Biol 12: 245–254
Garcia-Tsao G, Groszmann RJ, Fischer RL, Conn HO, Atterbury CE, Glickman M (1985) Portal pressure, presence of gastroesophageal varices and variceal bleeding. Hepatology 5: 419–424
Lebrec D, De Fleury P, Rueff B, Nahum H, Benhamou J-P (1980) Portal hypertension, size of esophageal varices, and risk of gastrointestinal bleeding in alcoholic cirrhosis. Gastroenterology 79: 1139–1144
Fleig WE, Stange EF, Ditschuneit H (1982) Upper gastrointestinal bleeding from downhill esophageal varices. Dig Dis Sci 27: 23–27
Johnson LS, Kinnear DG, Brown RA, Mulder DS (1978) “Downhill” esophageal varices. A rare cause of upper gastrointestinal bleeding. Arch Surg 113: 1463–1464
Palmer ED, Brick IB (1955) Varices of the distal esophagus in the apparent absence of portal and of superior caval hypertension. Am J Med Sci 230: 515–516
Palmer ED (1958) Esophageal varices associated with hiatus hernia in the absence of portal hypertension. Am J Med Sci 235: 677–679
Reynolds TB, Geller HM, Kuzma OT, Redeker AG (1960) Spontaneous decrease in portal pressure with clinical improvement in cirrhosis. N Engl J Med 263: 734–739
Calès P, Zabotto B, Meskens C, Caucanas JP, Vinel JP, Desmorat H, Fermanian J, Pascal JP (1990) Gastroesophageal endoscopie features in cirrhosis. Observer variability, interassociations and relationship to hepatic dysfunction. Gastroenterology 98: 156–162
Sallebert S, Mancheron H, Sevestre H, Dupas JL, Capron JP (1988) Etude histomorphométrique de la muqueuse gastrique au cours de l’hypertension portale. Gastroenterol Clin Biol 12: 89–92
Sarfeh IJ, Tarnawski A (1987) Gastric mucosal vasculopathy in portal hypertension. Gastroenterology 93: 1129–1131
Triger DR, Hosking SW (1989) The gastric mucosa in portal hypertension. J Hepatol 8: 267–272
Quintero E, Pique JM, Bombi JA, Bordas J, Sentis J, Montserra E, Bosch J, Ródes J (1987) Gastric mucosal vascular ectasias causing bleeding in cirrhosis. A distinct entity associated with hypergastrinemia and low serum levels of pepsinogen I. Gastroenterology 93: 1054–1061
Dilawary JB, Chawla (1987) Spontaneous (natural) splenoadrenal shunts in extrahepatic portal venous obstruction: A series of 20 cases. Gut 28: 1198–1200
Ohnishi K, Sato S, Saito M, Terabayashi H, Nakayama T, Saito M, Chin N, Iida S, Nomura F, Okuda K (1986) Clinical and portal hemodynamic features in cirrhotic patients having a large spontaneous splenorenal and/or gastrorenal shunt. Am J Gastroenterol 81: 450–455
Hanna SS, Smith RS, Henderson JM, Millikan WJ, Warren WD (1981) Reversal of hepatic encephalopathy after occlusion of total portasystemic shunts. Am J Surg 142: 285–289
Potts JR III, Henderson JM, Millikan WJ, Sones P, Warren WD (1984) Restoration of portal venous perfusion and reversal of encephalopathy by balloon occlusion of portal systemic shunt. Gastroenterology 87: 208–212
Moreau R, Lee SS, Hadengue A, Ozier Y, Sicot C, Lebrec D (1989) Relationship between oxygen transport and oxygen uptake in patients with cirrhosis: Effect of vasoactive drugs. Hepatology 9: 427–432
Krowka JK (1987) Sever hypoxemia associated with liver disease: Mayo Clinic experience and the experimental use of almitrine bismesylate. Mayo Clin Proc 62: 164–173
Krowka JK (1990) Hepatopulmonary syndrome: An evolving perspective in the era of liver transplantation. Hepatology 11: 138–142
Babbs C, Warnes TW, Haboubi NY (1988) Non-cirrhotic portal hypertension with hypoxaemia. Gut 29: 129–131
Shaldon S, Caesar J, Chiandussi L, Williams HS, Sheville E, Sherlock S (1961) The demonstration of porta-pulmonary anastomoses in portal cirrhosis with the use of radioactive krypton. N Engl J Med 265: 410–414
Agusti AGN, Roca R, Bosch J, Rodriguez-Roisin R (1990) The lung in patients with cirrhosis. J Hepatol 10: 251–257
Eriksson LS, Soderman C, Wahren J, Ericzon BG, Eleborg L, Hedenstierna G (1988) Is hypoxemia in cirrhotic patients due to a functional “hepatopulmonal syndrome”?. J Hepatol 7: S29
Stroller JK, Moodie D, Schiavone WA, Vogt D, Broughan T, Winkelman E, Rehm P, Carey W (1990) Reduction of intrapulmonary shunt and resolution of digital clubbing associated with primary biliary cirrhosis after liver transplanation. Hepatology 11: 54–58
Cohen MD, Rubin LJ, Taylor WE, Cuthbert JA (1983) Primary pulmonary hypertension: An unusual case associated with extrahepatic portal hypertension. Hepatology 3: 588–92
Lebrec D, Capron J-P, Dhumeaux D, Benhamou J-P (1979) Pulmonary hypertension complicating portal hypertension. Am Rev Respir Dis 120: 849–856
McDonnell PJ, Toye PA, Hutchins GM (1983) Primary pulmonary hypertension and cirrhosis: Are they related?. Am Rev Respir Dis 127: 437–41
Ruttner JR, Bartschi JP, Niedermann R, Schneider J (1980) Plexogenic pulmonary arteriopathy and liver cirrhosis. Thorax 35: 133–6
Hughes JD, Rubin LJ (1986) Primary pulmonary hypertension. An analysis of 28 cases and a review of the literature. Medicine 65: 56–72
Stanley JC, Fry WJ (1974) Pathogenesis and clinical significance of splenic artery aneurysms. Surgery 76: 898–909
Nishida O, Moriyasu F, Nakamura T, Ban N, Miura K, Sakai M, Uchino H, Miyaké T (1986) Hemodynamics of splenic artery aneurysm. Gastroenterology 90: 1042–1046
Branch AR (1982) Drugs as indicators of hepatic function. Hepatology 2: 97
Blei AT (1986) Pharmacokinetic-hemodynamic interactions in cirrhosis. Sem Liv Dis 6: 299–308
Larrey D, Branch RA (1983) Clearance by the liver: Current concepts in understanding the hepatic disposition of drugs. Sem Liv Dis 3: 285–297
Ohkubo H, Okuda K, Iida S, Ohnishi K, Ikawa S, Makino I (1984) Role of portal and splenic vein shunts and impaired hepatic extraction in the elevated serum bile acids in liver cirrhosis. Gastroenterology 86: 514–520
Blei AT, Friedman S, Gottsein J, Robertson G, Fung HO (1985) Pharmacokinetic-hemodynamic interactions between vasopressin and nitroglycerin: Comparison between intravenous and cutaneous routes of nitrate delivery. Hepatology 5: 264–270
Nordlinger B, Parquet M, Infante R, Moreels R, Blondiau P, Boschat M, Groussard M, Huguet C (1982) Noninvasive measurement of nutrient portal blood shunting: An experimental study with (14 C) ursodeoxycholic acid. Hepatology 2: 412–419
Porchet H, Bircher J (1982) Noninvasive assessment of portal-systemic shunting: Evaluation of a method to investigate systemic availability of oral glyceryl trinitrate by digital plethysmography. Gastroenterology 82: 629–637
Keiding S (1987) Hepatic clearance and liver blood flow. J Hepatol 4: 393–398
Farrell GC, Zaluzny L (1983) Portal vein ligation selectively lowers hepatic cytochrome P-450 levels in rats. Gastroenterology 85: 275–282
Pector JC, Verbeustel S, Lambillote JP (1975) Effects of portal arterialization on hepatic cytochrome P-450 in rats with porta-caval shunt. Digestion 12: 144–151
El-Raghy I, Back DJ, Osman F (1985) The pharmacokinetics of antipyrine in patients with graded severity of schistosomiasis. Br J Pharmacol 20: 313–316
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1991 Springer Japan
About this chapter
Cite this chapter
Hadengue, A., Lebrec, D., Benhamou, JP. (1991). Clinical Manifestations of Portal Hypertension. In: Okuda, K., Benhamou, JP. (eds) Portal Hypertension. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68361-2_19
Download citation
DOI: https://doi.org/10.1007/978-4-431-68361-2_19
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-68363-6
Online ISBN: 978-4-431-68361-2
eBook Packages: Springer Book Archive